Protection against adriamycin-induced cardiomyopathy by carnosine in rats: role of endogenous antioxidants.

Dursun N, Taşkın E, Oztürk F

Biological trace element research13 Oct 2010Cited by 23 (Europe PMC)

PMID20941549DOI10.1007/s12011-010-8875-yPepBankPUB-20941549

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, carnosine normalized left ventricular developed pressure after adriamycin-induced cardiac damage.
In plain wordsIn rats, carnosine restored heart pressure after adriamycin damage compared with adriamycin alone.
Peptide
L-carnosine
Outcome
Not applicableLeft ventricular developed pressure
Study
ratn: not reported in source
Adriamycin-induced cardiomyopathy
Comparator
Adriamycin alone
Outcome group
Heart function · Cardiovascular
Studied dose
10 mg/kg/day · intraperitonealAs given in this study (rat).
Source sentences
Summary
Carnosine treatment led to significant attenuation of adriamycin-induced cardiomyopathy revealed by normalization of the LVDP, ST interval, CK, SOD, GSH-Px, CAT, and lipid peroxidation.
3 context sentences(design, population, supporting numbers)
Summary · context
Results showed that adriamycin produced evident cardiac damage revealed by hemodynamic change, histological alterations, decreased plasma antioxidant enzymes activities, and increased lipid peroxidation to the control value.
Summary · context
The aim of this study was to investigate the effects of carnosine, a biological antioxidant, on the acute cardiac damage induced by a single dose of adriamycin in rats.
Summary · context
The experimental design consisted of four groups: Control (saline, i.p.); carnosine (CAR; 10 mg/kg/day, i.p.); adriamycin (ADR; 16 mg/kg on the 14th day, i.p.); carnosine with adriamycin.
Report a problemFND-2094154901
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, carnosine normalized the ST interval after adriamycin-induced cardiac damage.
In plain wordsIn rats, carnosine normalized the ST interval after adriamycin damage compared with adriamycin alone.
Peptide
L-carnosine
Outcome
Not applicableST interval
Study
ratn: not reported in source
Adriamycin-induced cardiomyopathy
Comparator
Adriamycin alone
Outcome group
Heart function · Cardiovascular
Studied dose
10 mg/kg/day · intraperitonealAs given in this study (rat).
Source sentences
Summary
Carnosine treatment led to significant attenuation of adriamycin-induced cardiomyopathy revealed by normalization of the LVDP, ST interval, CK, SOD, GSH-Px, CAT, and lipid peroxidation.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to investigate the effects of carnosine, a biological antioxidant, on the acute cardiac damage induced by a single dose of adriamycin in rats.
Summary · context
The experimental design consisted of four groups: Control (saline, i.p.); carnosine (CAR; 10 mg/kg/day, i.p.); adriamycin (ADR; 16 mg/kg on the 14th day, i.p.); carnosine with adriamycin.
Report a problemFND-2094154902
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, carnosine normalized creatine kinase after adriamycin-induced cardiac damage.
In plain wordsIn rats, carnosine normalized creatine kinase after adriamycin damage compared with adriamycin alone.
Peptide
L-carnosine
Outcome
Not applicableCreatine kinase
Study
ratn: not reported in source
Adriamycin-induced cardiomyopathy
Comparator
Adriamycin alone
Outcome group
Heart function · Cardiovascular
Studied dose
10 mg/kg/day · intraperitonealAs given in this study (rat).
Source sentences
Summary
Carnosine treatment led to significant attenuation of adriamycin-induced cardiomyopathy revealed by normalization of the LVDP, ST interval, CK, SOD, GSH-Px, CAT, and lipid peroxidation.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to investigate the effects of carnosine, a biological antioxidant, on the acute cardiac damage induced by a single dose of adriamycin in rats.
Summary · context
The experimental design consisted of four groups: Control (saline, i.p.); carnosine (CAR; 10 mg/kg/day, i.p.); adriamycin (ADR; 16 mg/kg on the 14th day, i.p.); carnosine with adriamycin.
Report a problemFND-2094154903
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, carnosine normalized superoxide dismutase activity reduced by adriamycin.
In plain wordsIn rats, carnosine restored superoxide dismutase activity compared with adriamycin alone.
Peptide
L-carnosine
Outcome
IncreaseSuperoxide dismutase activity
Study
ratn: not reported in source
Adriamycin-induced cardiomyopathy
Comparator
Adriamycin alone
Outcome group
Inflammation markers · Cardiovascular
Studied dose
10 mg/kg/day · intraperitonealAs given in this study (rat).
Source sentences
Summary
Carnosine treatment led to significant attenuation of adriamycin-induced cardiomyopathy revealed by normalization of the LVDP, ST interval, CK, SOD, GSH-Px, CAT, and lipid peroxidation.
3 context sentences(design, population, supporting numbers)
Summary · context
Results showed that adriamycin produced evident cardiac damage revealed by hemodynamic change, histological alterations, decreased plasma antioxidant enzymes activities, and increased lipid peroxidation to the control value.
Summary · context
The aim of this study was to investigate the effects of carnosine, a biological antioxidant, on the acute cardiac damage induced by a single dose of adriamycin in rats.
Summary · context
The experimental design consisted of four groups: Control (saline, i.p.); carnosine (CAR; 10 mg/kg/day, i.p.); adriamycin (ADR; 16 mg/kg on the 14th day, i.p.); carnosine with adriamycin.
Report a problemFND-2094154904
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, carnosine normalized glutathione peroxidase activity reduced by adriamycin.
In plain wordsIn rats, carnosine restored glutathione peroxidase activity compared with adriamycin alone.
Peptide
L-carnosine
Outcome
IncreaseGlutathione peroxidase activity
Study
ratn: not reported in source
Adriamycin-induced cardiomyopathy
Comparator
Adriamycin alone
Outcome group
Inflammation markers · Cardiovascular
Studied dose
10 mg/kg/day · intraperitonealAs given in this study (rat).
Source sentences
Summary
Carnosine treatment led to significant attenuation of adriamycin-induced cardiomyopathy revealed by normalization of the LVDP, ST interval, CK, SOD, GSH-Px, CAT, and lipid peroxidation.
3 context sentences(design, population, supporting numbers)
Summary · context
Results showed that adriamycin produced evident cardiac damage revealed by hemodynamic change, histological alterations, decreased plasma antioxidant enzymes activities, and increased lipid peroxidation to the control value.
Summary · context
The aim of this study was to investigate the effects of carnosine, a biological antioxidant, on the acute cardiac damage induced by a single dose of adriamycin in rats.
Summary · context
The experimental design consisted of four groups: Control (saline, i.p.); carnosine (CAR; 10 mg/kg/day, i.p.); adriamycin (ADR; 16 mg/kg on the 14th day, i.p.); carnosine with adriamycin.
Report a problemFND-2094154905
06AnimalAnimal study (in vivo)Efficacy outcome
In rats, carnosine normalized catalase activity reduced by adriamycin.
In plain wordsIn rats, carnosine restored catalase activity compared with adriamycin alone.
Peptide
L-carnosine
Outcome
IncreaseCatalase activity
Study
ratn: not reported in source
Adriamycin-induced cardiomyopathy
Comparator
Adriamycin alone
Outcome group
Inflammation markers · Cardiovascular
Studied dose
10 mg/kg/day · intraperitonealAs given in this study (rat).
Source sentences
Summary
Carnosine treatment led to significant attenuation of adriamycin-induced cardiomyopathy revealed by normalization of the LVDP, ST interval, CK, SOD, GSH-Px, CAT, and lipid peroxidation.
3 context sentences(design, population, supporting numbers)
Summary · context
Results showed that adriamycin produced evident cardiac damage revealed by hemodynamic change, histological alterations, decreased plasma antioxidant enzymes activities, and increased lipid peroxidation to the control value.
Summary · context
The aim of this study was to investigate the effects of carnosine, a biological antioxidant, on the acute cardiac damage induced by a single dose of adriamycin in rats.
Summary · context
The experimental design consisted of four groups: Control (saline, i.p.); carnosine (CAR; 10 mg/kg/day, i.p.); adriamycin (ADR; 16 mg/kg on the 14th day, i.p.); carnosine with adriamycin.
Report a problemFND-2094154906
07AnimalAnimal study (in vivo)Efficacy outcome
In rats, carnosine normalized lipid peroxidation increased by adriamycin.
In plain wordsIn rats, carnosine reduced lipid peroxidation compared with adriamycin alone.
Peptide
L-carnosine
Outcome
DecreaseLipid peroxidation
Study
ratn: not reported in source
Adriamycin-induced cardiomyopathy
Comparator
Adriamycin alone
Outcome group
Inflammation markers · Cardiovascular
Studied dose
10 mg/kg/day · intraperitonealAs given in this study (rat).
Source sentences
Summary
Carnosine treatment led to significant attenuation of adriamycin-induced cardiomyopathy revealed by normalization of the LVDP, ST interval, CK, SOD, GSH-Px, CAT, and lipid peroxidation.
3 context sentences(design, population, supporting numbers)
Summary · context
Results showed that adriamycin produced evident cardiac damage revealed by hemodynamic change, histological alterations, decreased plasma antioxidant enzymes activities, and increased lipid peroxidation to the control value.
Summary · context
The aim of this study was to investigate the effects of carnosine, a biological antioxidant, on the acute cardiac damage induced by a single dose of adriamycin in rats.
Summary · context
The experimental design consisted of four groups: Control (saline, i.p.); carnosine (CAR; 10 mg/kg/day, i.p.); adriamycin (ADR; 16 mg/kg on the 14th day, i.p.); carnosine with adriamycin.
Report a problemFND-2094154907
08AnimalAnimal study (in vivo)Efficacy outcome
In rats, carnosine prevented the increase in oxidative stress induced by adriamycin.
In plain wordsIn rats, carnosine prevented increased oxidative stress compared with adriamycin alone.
Peptide
L-carnosine
Outcome
DecreaseOxidative stress
Study
ratn: not reported in source
Adriamycin-induced cardiomyopathy
Comparator
Adriamycin alone
Outcome group
Inflammation markers · Cardiovascular
Studied dose
10 mg/kg/day · intraperitonealAs given in this study (rat).
Source sentences
Summary
An increase in oxidative stress and inactivation of SOD, GSH-Px, CAT by a single dose of adriamycin were prevented when carnosine was given 2 weeks before and on the same day adriamycin treatment was administered.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to investigate the effects of carnosine, a biological antioxidant, on the acute cardiac damage induced by a single dose of adriamycin in rats.
Summary · context
The experimental design consisted of four groups: Control (saline, i.p.); carnosine (CAR; 10 mg/kg/day, i.p.); adriamycin (ADR; 16 mg/kg on the 14th day, i.p.); carnosine with adriamycin.
Report a problemFND-2094154908

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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