Skip to content

Study · In vitro (cells) · mouse · 2011

4 results

Muscle injury-induced thymosin β4 acts as a chemoattractant for myoblasts.

Tokura Y, Nakayama Y, Fukada S, Nara N, Yamamoto H, Matsuda R, Hara T

Journal of biochemistry29 Sept 2010Cited by 25 (Europe PMC)

PMID20880960 (opens in a new tab)DOI10.1093/jb/mvq115 (opens in a new tab)PepBankPUB-20880960
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In C2C12 myoblastic cells, thymosin beta‑4 and its sulphoxized form significantly accelerated wound closure.

    In plain wordsIn mouse muscle cells in a dish, thymosin beta‑4 and its oxidised form sped up wound closure.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseWound closure of C2C12 myoblastic cells
    Study

    mousen: not reported in source

    C2C12 myoblastic cells
    Outcome group
    Wound healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that both Tβ4 and its sulphoxized form significantly accelerated wound closure and increased the chemotaxis of C2C12 myoblastic cells.
  2. 02LabIn vitro (cells)Activity measurement

    In C2C12 myoblastic cells, thymosin beta‑4 and its sulphoxized form increased chemotaxis.

    In plain wordsIn mouse muscle cells in a dish, thymosin beta‑4 and its oxidised form increased cell movement toward the peptide.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseChemotaxis of C2C12 myoblastic cells
    Study

    mousen: not reported in source

    C2C12 myoblastic cells
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that both Tβ4 and its sulphoxized form significantly accelerated wound closure and increased the chemotaxis of C2C12 myoblastic cells.
  3. 03LabIn vitro (cells)Activity measurement

    Primary myoblasts and myocytes from adult mouse satellite cells were chemoattracted to the sulphoxized form of thymosin beta‑4.

    In plain wordsIn mouse muscle cells in a dish, the oxidised form of thymosin beta‑4 attracted primary muscle cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseChemoattraction of primary myoblasts and myocytes to sulphoxized thymosin beta-4
    Study

    mousen: not reported in source

    primary myoblasts and myocytes from muscle satellite cells of adult mice
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, we showed that primary myoblasts and myocytes derived from muscle satellite cells of adult mice were chemoattracted to sulphoxized form of Tβ4.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 04AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In injured mouse skeletal muscle, thymosin beta‑4 mRNA was up-regulated in the early stage of regenerating muscle fibres and in inflammatory haematopoietic cells.

    In plain wordsIn mice, the body's own thymosin beta‑4 rose early in injured muscle that was regenerating.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta-4 mRNA in regenerating muscle
    Study

    mousen: not reported in source

    injured skeletal muscle
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    The mRNA levels of 'Tβ4' and 'thymosin β10' were up-regulated in the early stage of regenerating muscle fibres and inflammatory haematopoietic cells in the injured skeletal muscles of mice.
    1 context sentence
    Summary · context
    We investigated the expression of 'Tβ4' and 'thymosin β10', a closely related peptide, during skeletal muscle regeneration in mice and chemotactic responses of myoblasts to these peptides.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.