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Study · Measured the body's own peptide · 2012

7 results

Evaluation of thymosin β4 in the regulation of epithelial-mesenchymal transformation in urothelial carcinoma.

Wang ZY, Zeng FQ, Zhu ZH, Jiang GS, Lv L, Wan F, Dong R, Xiao XY, Xing SA

Urologic oncology22 Sept 2010Cited by 15 (Europe PMC)

PMID20864366 (opens in a new tab)DOI10.1016/j.urolonc.2010.02.009 (opens in a new tab)PepBankPUB-20864366
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured7

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyMechanism

    In patients with bladder transitional cell carcinoma, expression levels of Tβ4, ILK, E-cadherin and β-catenin were strongly correlated.

    In plain wordsIn bladder cancer patients, the body's own Tβ4 levels were linked to levels of three other proteins involved in cell adhesion.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCorrelation of Tβ4, ILK, E-cadherin and β-catenin expression
    Study

    n: not reported in source

    bladder transitional cell carcinoma patients
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    A strong correlation between the expression levels of Tβ4, ILK, E-cadherin, and β-catenin was found in the bladder transitional cell carcinoma (TCC) patients.
    1 context sentence
    Summary · context
    Quantitative RT-PCR, Western blotting, and immunohistochemical study of adhesion molecules Tβ4, ILK, E-cadherin, and β-catenin involved in EMT were carried out.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In BIU-87 and T24 bladder cancer cells, Tβ4 overexpression went with loss of E-cadherin.

    In plain wordsIn bladder cancer cells, raising the cells' own Tβ4 went with loss of the adhesion protein E-cadherin.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseE-cadherin in Tβ4-overexpressing cells
    Study

    humann: not reported in source

    BIU-87 and T24 bladder cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    In the BIU-87 and T24 bladder cancer cells overexpressing Tβ4, which were accompanied by a loss of E-cadherin as well as a cytosolic accumulation of β-catenin, up-regulation of ILK was also revealed.
    1 context sentence
    Summary · context
    Quantitative RT-PCR, Western blotting, and immunohistochemical study of adhesion molecules Tβ4, ILK, E-cadherin, and β-catenin involved in EMT were carried out.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    In BIU-87 and T24 bladder cancer cells, Tβ4 overexpression went with cytosolic accumulation of β-catenin.

    In plain wordsIn bladder cancer cells, raising the cells' own Tβ4 went with a build-up of β-catenin inside the cell.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCytosolic β-catenin in Tβ4-overexpressing cells
    Study

    humann: not reported in source

    BIU-87 and T24 bladder cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    In the BIU-87 and T24 bladder cancer cells overexpressing Tβ4, which were accompanied by a loss of E-cadherin as well as a cytosolic accumulation of β-catenin, up-regulation of ILK was also revealed.
    1 context sentence
    Summary · context
    Quantitative RT-PCR, Western blotting, and immunohistochemical study of adhesion molecules Tβ4, ILK, E-cadherin, and β-catenin involved in EMT were carried out.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelIn vitro (cells)Mechanism

    In BIU-87 and T24 bladder cancer cells, Tβ4 overexpression went with up-regulation of ILK.

    In plain wordsIn bladder cancer cells, raising the cells' own Tβ4 went with higher levels of ILK.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseILK in Tβ4-overexpressing cells
    Study

    humann: not reported in source

    BIU-87 and T24 bladder cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    In the BIU-87 and T24 bladder cancer cells overexpressing Tβ4, which were accompanied by a loss of E-cadherin as well as a cytosolic accumulation of β-catenin, up-regulation of ILK was also revealed.
    1 context sentence
    Summary · context
    Quantitative RT-PCR, Western blotting, and immunohistochemical study of adhesion molecules Tβ4, ILK, E-cadherin, and β-catenin involved in EMT were carried out.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  5. 05LabEndogenous levelIn vitro (cells)Mechanism

    In bladder cancer cells, inhibition of Tβ4 expression with lentiviral shRNA could raise EMT-like phenotypic changes.

    In plain wordsIn bladder cancer cells, lowering the cells' own Tβ4 could raise cell changes linked to spread of cancer.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseEMT-like phenotypic changes after Tβ4 knockdown
    Study

    humann: not reported in source

    bladder cancer cells with Tβ4 shRNA
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    The inhibition of the Tβ4 expression with lentiviral shRNA vector could raise EMT-like phenotypic changes, significantly depressed motility, and subsequent invasiveness of bladder cancer cells.
    1 context sentence
    Summary · context
    Quantitative RT-PCR, Western blotting, and immunohistochemical study of adhesion molecules Tβ4, ILK, E-cadherin, and β-catenin involved in EMT were carried out.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  6. 06LabEndogenous levelIn vitro (cells)Mechanism

    In bladder cancer cells, inhibition of Tβ4 expression with lentiviral shRNA significantly depressed motility.

    In plain wordsIn bladder cancer cells, lowering the cells' own Tβ4 reduced how much the cells moved.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCell motility after Tβ4 knockdown
    Study

    humann: not reported in source

    bladder cancer cells with Tβ4 shRNA
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    The inhibition of the Tβ4 expression with lentiviral shRNA vector could raise EMT-like phenotypic changes, significantly depressed motility, and subsequent invasiveness of bladder cancer cells.
    1 context sentence
    Summary · context
    Quantitative RT-PCR, Western blotting, and immunohistochemical study of adhesion molecules Tβ4, ILK, E-cadherin, and β-catenin involved in EMT were carried out.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  7. 07LabEndogenous levelIn vitro (cells)Mechanism

    In bladder cancer cells, inhibition of Tβ4 expression with lentiviral shRNA depressed invasiveness.

    In plain wordsIn bladder cancer cells, lowering the cells' own Tβ4 reduced the ability of cells to invade.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseInvasiveness after Tβ4 knockdown
    Study

    humann: not reported in source

    bladder cancer cells with Tβ4 shRNA
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    The inhibition of the Tβ4 expression with lentiviral shRNA vector could raise EMT-like phenotypic changes, significantly depressed motility, and subsequent invasiveness of bladder cancer cells.
    1 context sentence
    Summary · context
    Quantitative RT-PCR, Western blotting, and immunohistochemical study of adhesion molecules Tβ4, ILK, E-cadherin, and β-catenin involved in EMT were carried out.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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