In human skin samples, degarelix did not significantly affect basal histamine release across the tested concentration range.
In plain wordsIn lab tests using human skin, degarelix did not significantly change histamine release compared with basal release.
- Peptide
- Degarelix
- Outcome
- No significant changeHistamine release
- Study
humann: not reported in source
Human skin samples obtained during cosmetic plastic surgery- Comparator
- Basal histamine release
- Outcome group
- Immune response · Immune and inflammation
- Studied dose
- 3 to 300 µg ml(-1)As given in this study (human).
Source sentences
Degarelix had no significant effect on basal histamine release in the 3 to 300 µg ml(-1) concentration range.
3 context sentences(design, population, supporting numbers)
In this study we have compared the histamine-releasing potential of four approved and marketed antagonists, degarelix, cetrorelix, abarelix and ganirelix in an ex vivo model of human skin samples.
Human skin samples were obtained during cosmetic plastic surgery and kept in oxygenated saline solution.
The samples were incubated either without or at different concentrations of the antagonists (3, 30 or 300 µg ml(-1) for all, except for ganirelix 1, 10 or 100 µg ml(-1) ).