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Study · In vitro (cells) · 2010

5 results

Kisspeptin-10 inhibits bone-directed migration of GPR54-positive breast cancer cells: Evidence for a dose-window effect.

Olbrich T, Ziegler E, Türk G, Schubert A, Emons G, Gründker C

Gynecologic oncology15 Sept 2010Cited by 40 (Europe PMC)

PMID20832102 (opens in a new tab)DOI10.1016/j.ygyno.2010.08.018 (opens in a new tab)PepBankPUB-20832102
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In GPR54-positive breast cancer cells, KP-10 reduced the ability to invade a reconstituted basement membrane, with significance in a dose-window of 10⁻⁹ M to 10⁻¹¹ M.

    In plain wordsIn cancer cells in the lab, KP-10 reduced their ability to invade, within a narrow range of doses.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseBreast cancer cell invasion through basement membrane
    Study

    n: not reported in source

    GPR54-positive breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10⁻⁹ M to 10⁻¹¹ MAs given in this study.

    Source sentences

    Summary
    Treatment with KP-10 reduced the ability to invade a reconstituted basement membrane
    2 context sentences
    Summary · context
    This effect was significant in a dose-window of 10⁻⁹ M to 10⁻¹¹ M
    Summary · context
    In this study we have analyzed whether Kp-10 treatment affects bone-directed migration of GPR54-positive breast cancer cells.
  2. 02LabIn vitro (cells)Efficacy outcome

    In GPR54-positive breast cancer cells, KP-10 reduced migration in response to the cellular stimulus, with significance in a dose-window of 10⁻⁹ M to 10⁻¹¹ M.

    In plain wordsIn cancer cells in the lab, KP-10 reduced their movement toward bone-like cells, within a narrow range of doses.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseBreast cancer cell migration toward cellular stimulus
    Study

    n: not reported in source

    GPR54-positive breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10⁻⁹ M to 10⁻¹¹ MAs given in this study.

    Source sentences

    Summary
    and to migrate in response to the cellular stimulus.
    2 context sentences
    Summary · context
    This effect was significant in a dose-window of 10⁻⁹ M to 10⁻¹¹ M
    Summary · context
    In this study we have analyzed whether Kp-10 treatment affects bone-directed migration of GPR54-positive breast cancer cells.
  3. 03LabIn vitro (cells)Mechanism

    In breast cancer cells, KP-10 treatment significantly reduced expression of the chemokine receptor CXCR4.

    In plain wordsIn cancer cells in the lab, KP-10 lowered the level of a receptor linked to migration.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseCXCR4 expression in breast cancer cells
    Study

    n: not reported in source

    GPR54-positive breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Searching for the molecular mechanisms we found that KP-10 treatment significantly reduces expression of the chemokine receptor CXCR4 by the breast cancer cells.
    1 context sentence
    Summary · context
    In this study we have analyzed whether Kp-10 treatment affects bone-directed migration of GPR54-positive breast cancer cells.
  4. 04LabIn vitro (cells)Mechanism

    In co-culture, KP-10 significantly reduced SDF-1 expression and secretion by MG63 osteoblast-like cells.

    In plain wordsIn the lab, KP-10 lowered the production and release of SDF-1 by bone-like cells.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseSDF-1 expression and secretion by MG63 cells
    Study

    n: not reported in source

    MG63 osteoblast-like cells co-cultured with breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, expression and secretion of its ligand SDF-1 by the MG63 cells were significantly reduced.
    1 context sentence
    Summary · context
    In this study we have analyzed whether Kp-10 treatment affects bone-directed migration of GPR54-positive breast cancer cells.
  5. 05LabIn vitro (cells)Mechanism

    In breast cancer cells, KP-10 down-regulated SDF-1-induced CXCR4 signaling.

    In plain wordsIn cancer cells in the lab, KP-10 turned down the signalling triggered by SDF-1.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseSDF-1-induced CXCR4 signaling
    Study

    n: not reported in source

    GPR54-positive breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, SDF-1-induced CXCR4 signaling was down-regulated.
    1 context sentence
    Summary · context
    In this study we have analyzed whether Kp-10 treatment affects bone-directed migration of GPR54-positive breast cancer cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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