Central administration of kisspeptin-10 inhibits water and sodium excretion of anesthetized male rats and the involvement of arginine vasopressin.

Ten SC, Gu SY, Niu YF, An XF, Yan M, He M

Endocrine research1 Jan 2010Cited by 17 (Europe PMC)

PMID20712435DOI10.3109/07435801003769995PepBankPUB-20712435

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized male rats, intracerebroventricular kisspeptin‑10 (5 nmol) significantly decreased urine flow from 30 to 60 min post-injection.
In plain wordsIn rats, kisspeptin‑10 injected into the brain reduced urine flow.
Peptide
Kisspeptin-10
Outcome
DecreaseUrine flow
Study
ratn: not reported in source
Anesthetized male rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
5 nmol · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
The urine flow, sodium excretion, and free water clearance decreased significantly by icv injection of 5 nmol kisspeptin-10 (p < 0.05) from 30 to 60 min post-injection.
1 context sentence(design, population, supporting numbers)
Summary · context
The intracerebroventricular (icv) administration and radioimmunoassay were used to observe the effect of kisspeptin-10 on urine flow, sodium and potassium excretion, plasma arginine vasopressin (AVP), and atrial natriuretic peptide (ANP) concentrations in anesthetized male rats.
Report a problemFND-2071243501
02AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized male rats, intracerebroventricular kisspeptin‑10 (5 nmol) significantly decreased sodium excretion from 30 to 60 min post-injection.
In plain wordsIn rats, kisspeptin‑10 injected into the brain reduced the amount of sodium lost in urine.
Peptide
Kisspeptin-10
Outcome
DecreaseSodium excretion
Study
ratn: not reported in source
Anesthetized male rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
5 nmol · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
The urine flow, sodium excretion, and free water clearance decreased significantly by icv injection of 5 nmol kisspeptin-10 (p < 0.05) from 30 to 60 min post-injection.
1 context sentence(design, population, supporting numbers)
Summary · context
The intracerebroventricular (icv) administration and radioimmunoassay were used to observe the effect of kisspeptin-10 on urine flow, sodium and potassium excretion, plasma arginine vasopressin (AVP), and atrial natriuretic peptide (ANP) concentrations in anesthetized male rats.
Report a problemFND-2071243502
03AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized male rats, intracerebroventricular kisspeptin‑10 (5 nmol) significantly decreased free water clearance from 30 to 60 min post-injection.
In plain wordsIn rats, kisspeptin‑10 injected into the brain reduced free water clearance by the kidneys.
Peptide
Kisspeptin-10
Outcome
DecreaseFree water clearance
Study
ratn: not reported in source
Anesthetized male rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
5 nmol · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
The urine flow, sodium excretion, and free water clearance decreased significantly by icv injection of 5 nmol kisspeptin-10 (p < 0.05) from 30 to 60 min post-injection.
1 context sentence(design, population, supporting numbers)
Summary · context
The intracerebroventricular (icv) administration and radioimmunoassay were used to observe the effect of kisspeptin-10 on urine flow, sodium and potassium excretion, plasma arginine vasopressin (AVP), and atrial natriuretic peptide (ANP) concentrations in anesthetized male rats.
Report a problemFND-2071243503
04AnimalAnimal study (in vivo)Mechanism
In anesthetized male rats, plasma AVP concentrations increased significantly 30 min after intracerebroventricular kisspeptin‑10 (5 nmol).
In plain wordsIn rats, kisspeptin‑10 injected into the brain raised blood levels of the hormone vasopressin.
Peptide
Kisspeptin-10
Outcome
IncreasePlasma arginine vasopressin (AVP)
Study
ratn: not reported in source
Anesthetized male rats
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
5 nmol · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Meanwhile, plasma AVP concentrations increased significantly 30 min after the icv injection of 5 nmol kisspeptin-10 (p < 0.05), whereas the equal dose of kisspeptin-10 did not significantly change plasma ANP concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
The intracerebroventricular (icv) administration and radioimmunoassay were used to observe the effect of kisspeptin-10 on urine flow, sodium and potassium excretion, plasma arginine vasopressin (AVP), and atrial natriuretic peptide (ANP) concentrations in anesthetized male rats.
Report a problemFND-2071243504
05AnimalAnimal study (in vivo)Mechanism
In anesthetized male rats, kisspeptin‑10 (5 nmol) did not significantly change plasma ANP concentrations.
In plain wordsIn rats, kisspeptin‑10 injected into the brain did not change blood levels of the hormone ANP.
Peptide
Kisspeptin-10
Outcome
No significant changePlasma atrial natriuretic peptide (ANP)
Study
ratn: not reported in source
Anesthetized male rats
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
5 nmol · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Meanwhile, plasma AVP concentrations increased significantly 30 min after the icv injection of 5 nmol kisspeptin-10 (p < 0.05), whereas the equal dose of kisspeptin-10 did not significantly change plasma ANP concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
The intracerebroventricular (icv) administration and radioimmunoassay were used to observe the effect of kisspeptin-10 on urine flow, sodium and potassium excretion, plasma arginine vasopressin (AVP), and atrial natriuretic peptide (ANP) concentrations in anesthetized male rats.
Report a problemFND-2071243505
06AnimalAnimal study (in vivo)Safety outcome
In anesthetized male rats, mean arterial blood pressure did not significantly change during the experiment.
In plain wordsIn rats given kisspeptin‑10 in the brain, blood pressure did not change significantly.
Peptide
Kisspeptin-10
Outcome
No significant changeMean arterial blood pressure
Study
ratn: not reported in source
Anesthetized male rats
Outcome group
Blood pressure · Cardiovascular
Studied dose
5 nmol · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
The mean arterial blood pressure, heart rate, and potassium excretion did not significantly change during the experiment.
1 context sentence(design, population, supporting numbers)
Summary · context
The intracerebroventricular (icv) administration and radioimmunoassay were used to observe the effect of kisspeptin-10 on urine flow, sodium and potassium excretion, plasma arginine vasopressin (AVP), and atrial natriuretic peptide (ANP) concentrations in anesthetized male rats.
Report a problemFND-2071243506
07AnimalAnimal study (in vivo)Safety outcome
In anesthetized male rats, heart rate did not significantly change during the experiment.
In plain wordsIn rats given kisspeptin‑10 in the brain, heart rate did not change significantly.
Peptide
Kisspeptin-10
Outcome
No significant changeHeart rate
Study
ratn: not reported in source
Anesthetized male rats
Outcome group
Heart function · Cardiovascular
Studied dose
5 nmol · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
The mean arterial blood pressure, heart rate, and potassium excretion did not significantly change during the experiment.
1 context sentence(design, population, supporting numbers)
Summary · context
The intracerebroventricular (icv) administration and radioimmunoassay were used to observe the effect of kisspeptin-10 on urine flow, sodium and potassium excretion, plasma arginine vasopressin (AVP), and atrial natriuretic peptide (ANP) concentrations in anesthetized male rats.
Report a problemFND-2071243507
08AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized male rats, potassium excretion did not significantly change during the experiment.
In plain wordsIn rats given kisspeptin‑10 in the brain, potassium lost in urine did not change significantly.
Peptide
Kisspeptin-10
Outcome
No significant changePotassium excretion
Study
ratn: not reported in source
Anesthetized male rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
5 nmol · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
The mean arterial blood pressure, heart rate, and potassium excretion did not significantly change during the experiment.
1 context sentence(design, population, supporting numbers)
Summary · context
The intracerebroventricular (icv) administration and radioimmunoassay were used to observe the effect of kisspeptin-10 on urine flow, sodium and potassium excretion, plasma arginine vasopressin (AVP), and atrial natriuretic peptide (ANP) concentrations in anesthetized male rats.
Report a problemFND-2071243508
09AnimalAnimal study (in vivo)Efficacy outcome
In rats with bilateral renal sympathetic denervation, pretreatment with kisspeptin‑10 (5 nmol) still significantly decreased urine flow.
In plain wordsIn rats whose kidney nerves were cut, kisspeptin‑10 in the brain still reduced urine flow.
Peptide
Kisspeptin-10
Outcome
DecreaseUrine flow in renal sympathetic denervated rats
Study
ratn: not reported in source
Anesthetized male rats with bilateral renal sympathetic denervation
Outcome group
Kidney function · Kidney and urinary
Studied dose
5 nmol · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Furthermore, pretreatment with 5 nmol kisspeptin-10 could still significantly decrease urine flow and sodium excretion in renal sympathetic denervated rats.
1 context sentence(design, population, supporting numbers)
Summary · context
The intracerebroventricular (icv) administration and radioimmunoassay were used to observe the effect of kisspeptin-10 on urine flow, sodium and potassium excretion, plasma arginine vasopressin (AVP), and atrial natriuretic peptide (ANP) concentrations in anesthetized male rats.
Report a problemFND-2071243509
10AnimalAnimal study (in vivo)Efficacy outcome
In rats with bilateral renal sympathetic denervation, pretreatment with kisspeptin‑10 (5 nmol) still significantly decreased sodium excretion.
In plain wordsIn rats whose kidney nerves were cut, kisspeptin‑10 in the brain still reduced sodium lost in urine.
Peptide
Kisspeptin-10
Outcome
DecreaseSodium excretion in renal sympathetic denervated rats
Study
ratn: not reported in source
Anesthetized male rats with bilateral renal sympathetic denervation
Outcome group
Kidney function · Kidney and urinary
Studied dose
5 nmol · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Furthermore, pretreatment with 5 nmol kisspeptin-10 could still significantly decrease urine flow and sodium excretion in renal sympathetic denervated rats.
1 context sentence(design, population, supporting numbers)
Summary · context
The intracerebroventricular (icv) administration and radioimmunoassay were used to observe the effect of kisspeptin-10 on urine flow, sodium and potassium excretion, plasma arginine vasopressin (AVP), and atrial natriuretic peptide (ANP) concentrations in anesthetized male rats.
Report a problemFND-2071243510

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.