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Study · In vitro (cells) · 2010

3 results

Thymosin β4 induces the expression of vascular endothelial growth factor (VEGF) in a hypoxia-inducible factor (HIF)-1α-dependent manner.

Jo JO, Kim SR, Bae MK, Kang YJ, Ock MS, Kleinman HK, Cha HJ

Biochimica et biophysica acta4 Aug 2010Cited by 36 (Europe PMC)

PMID20691219 (opens in a new tab)DOI10.1016/j.bbamcr.2010.07.005 (opens in a new tab)PepBankPUB-20691219
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cells, thymosin beta‑4 induced VEGF expression by increasing the stability of HIF-1alpha protein.

    In plain wordsIn cells, thymosin beta‑4 raised VEGF expression.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseVEGF expression
    Study

    n: not reported in source

    Outcome group
    Angiogenesis · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that thymosin β4 induces VEGF expression by an increase in the stability of HIF-1α protein.
  2. 02LabIn vitro (cells)Mechanism

    In cells, thymosin beta‑4 increased the stability of HIF-1alpha protein.

    In plain wordsIn cells, thymosin beta‑4 made HIF-1alpha protein more stable.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseHIF-1alpha protein stability
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that thymosin β4 induces VEGF expression by an increase in the stability of HIF-1α protein.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03LabEndogenous levelEx vivo tissueMechanism

    In human colon cancer biopsies on a tissue microarray, the body's own thymosin beta‑4 and HIF-1alpha co-localized.

    In plain wordsIn lab tests of colon cancer tissue, the body's own thymosin beta‑4 and HIF-1alpha appeared in the same places.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCo-localization of thymosin beta-4 and HIF-1alpha
    Study

    humann: not reported in source

    Colon cancer tissue microarray
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    Analysis of the expression patterns of thymosin β4 and HIF-1α in colon cancer tissue microarray showed that thymosin β4 and HIF-1α co-localized in these biopsies.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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