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Study · Animal study (in vivo) · rat · 2010

6 results

Thymosin beta4 improves functional neurological outcome in a rat model of embolic stroke.

Morris DC, Chopp M, Zhang L, Lu M, Zhang ZG

Neuroscience1 Aug 2010Cited by 78 (Europe PMC)

PMID20627173 (opens in a new tab)PMCIDPMC2907184 (opens in a new tab)DOI10.1016/j.neuroscience.2010.05.017 (opens in a new tab)PepBankPUB-20627173
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with embolic stroke, Tbeta4 significantly improved overall performance in the adhesive-removal test compared with controls.

    In plain wordsIn rats with stroke, thymosin beta‑4 improved results in a sensorimotor test compared with saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseAdhesive-removal test
    Study

    ratn = 18

    Embolic middle cerebral artery occlusion (MCAo), male Wistar rats
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    6 mg/kg · intraperitoneal · first dose 24 h after MCAo, then every 3 days for four additional doses; assessed to 56 daysAs given in this study (rat).

    Source sentences

    Summary
    Ischemic rats treated with Tbeta4 demonstrated a significant overall improvement (P<0.01) in the ART and the mNSS when compared to controls. Significant improvement was observed beginning at 14 and 35 days, respectively.
    3 context sentences
    Summary · context
    Male Wistar rats (n=18) were subjected to embolic middle cerebral artery occlusion (MCAo).
    Summary · context
    Tbeta4 (6 mg/kg, IP) was administered 24 h after MCAo and then every 3 days for four additional doses (n=9).
    Summary · context
    Rats treated with saline were used as a control (n=9).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with embolic stroke, Tbeta4 significantly improved the modified Neurological Severity Score compared with controls.

    In plain wordsIn rats with stroke, thymosin beta‑4 improved neurological scores compared with saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseModified Neurological Severity Score
    Study

    ratn = 18

    Embolic middle cerebral artery occlusion (MCAo), male Wistar rats
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    6 mg/kg · intraperitoneal · first dose 24 h after MCAo, then every 3 days for four additional doses; assessed to 56 daysAs given in this study (rat).

    Source sentences

    Summary
    Ischemic rats treated with Tbeta4 demonstrated a significant overall improvement (P<0.01) in the ART and the mNSS when compared to controls. Significant improvement was observed beginning at 14 and 35 days, respectively.
    3 context sentences
    Summary · context
    Male Wistar rats (n=18) were subjected to embolic middle cerebral artery occlusion (MCAo).
    Summary · context
    Tbeta4 (6 mg/kg, IP) was administered 24 h after MCAo and then every 3 days for four additional doses (n=9).
    Summary · context
    Rats treated with saline were used as a control (n=9).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with embolic stroke, lesion volumes did not differ significantly between Tbeta4 and control groups.

    In plain wordsIn rats with stroke, thymosin beta‑4 did not significantly change lesion size compared with saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeLesion volume
    Study

    ratn = 18

    Embolic middle cerebral artery occlusion (MCAo), male Wistar rats
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    6 mg/kg · intraperitoneal · first dose 24 h after MCAo, then every 3 days for four additional doses; assessed to 56 daysAs given in this study (rat).

    Source sentences

    Summary
    Lesion volumes showed no significant differences between the two groups.
    3 context sentences
    Summary · context
    Male Wistar rats (n=18) were subjected to embolic middle cerebral artery occlusion (MCAo).
    Summary · context
    Tbeta4 (6 mg/kg, IP) was administered 24 h after MCAo and then every 3 days for four additional doses (n=9).
    Summary · context
    Rats treated with saline were used as a control (n=9).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with embolic stroke, Tbeta4 increased myelinated axons in the ischemic boundary.

    In plain wordsIn rats with stroke, thymosin beta‑4 increased myelinated nerve fibers near the damaged area.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMyelinated axons in the ischemic boundary
    Study

    ratn = 18

    Embolic middle cerebral artery occlusion (MCAo), male Wistar rats
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    6 mg/kg · intraperitoneal · first dose 24 h after MCAo, then every 3 days for four additional doses; assessed to 56 daysAs given in this study (rat).

    Source sentences

    Summary
    Treatment with Tbeta4 increased myelinated axons and increased vessel density in the ischemic boundary (P<0.05)
    3 context sentences
    Summary · context
    Male Wistar rats (n=18) were subjected to embolic middle cerebral artery occlusion (MCAo).
    Summary · context
    Tbeta4 (6 mg/kg, IP) was administered 24 h after MCAo and then every 3 days for four additional doses (n=9).
    Summary · context
    Rats treated with saline were used as a control (n=9).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with embolic stroke, Tbeta4 increased vessel density in the ischemic boundary.

    In plain wordsIn rats with stroke, thymosin beta‑4 increased blood vessel density near the damaged area.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseVessel density in the ischemic boundary
    Study

    ratn = 18

    Embolic middle cerebral artery occlusion (MCAo), male Wistar rats
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    6 mg/kg · intraperitoneal · first dose 24 h after MCAo, then every 3 days for four additional doses; assessed to 56 daysAs given in this study (rat).

    Source sentences

    Summary
    Treatment with Tbeta4 increased myelinated axons and increased vessel density in the ischemic boundary (P<0.05)
    3 context sentences
    Summary · context
    Male Wistar rats (n=18) were subjected to embolic middle cerebral artery occlusion (MCAo).
    Summary · context
    Tbeta4 (6 mg/kg, IP) was administered 24 h after MCAo and then every 3 days for four additional doses (n=9).
    Summary · context
    Rats treated with saline were used as a control (n=9).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with embolic stroke, Tbeta4 augmented remyelination, associated with more oligodendrocyte progenitor cells and myelinating oligodendrocytes.

    In plain wordsIn rats with stroke, thymosin beta‑4 increased nerve fiber remyelination and related support cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseRemyelination and oligodendrocyte lineage cells
    Study

    ratn = 18

    Embolic middle cerebral artery occlusion (MCAo), male Wistar rats
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    6 mg/kg · intraperitoneal · first dose 24 h after MCAo, then every 3 days for four additional doses; assessed to 56 daysAs given in this study (rat).

    Source sentences

    Summary
    augmented remyelination which was associated with an increase of oligodendrocyte progenitor cells (OPCs) and myelinating oligodendrocytes (P<0.05).
    3 context sentences
    Summary · context
    Male Wistar rats (n=18) were subjected to embolic middle cerebral artery occlusion (MCAo).
    Summary · context
    Tbeta4 (6 mg/kg, IP) was administered 24 h after MCAo and then every 3 days for four additional doses (n=9).
    Summary · context
    Rats treated with saline were used as a control (n=9).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

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