Effects of GH secretagogues on contractility and Ca2+ homeostasis of isolated adult rat ventricular myocytes.

Sun Q, Ma Y, Zhang L, Zhao YF, Zang WJ, Chen C

Endocrinology7 Jul 2010Cited by 30 (Europe PMC)

PMID20610573DOI10.1210/en.2009-1432PepBankPUB-20610573

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

3 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In isolated adult rat ventricular myocytes, hexarelin and ghrelin produced a concentration-dependent positive inotropic effect.
In plain wordsIn isolated rat heart cells, hexarelin and ghrelin made the cells contract more strongly, and a higher concentration gave a larger effect.
Peptide
Hexarelin
Outcome
IncreaseVentricular myocyte shortening (inotropic effect)
Study
ratn: not reported in source
Freshly isolated adult Wistar rat ventricular myocytes
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
GHSs produced a positive inotropic effect in a concentration-dependent manner
2 context sentences(design, population, supporting numbers)
Summary · context
hexarelin and ghrelin increase the I(Ca,L), through GHS-R1a receptor and protein kinase C signalling cascade, which contribute to its direct positive inotropic effect on cardiomyocytes.
Summary · context
In the present study, we investigated the immediate effects of GHSs on isolated ventricular myocyte shortening, intracellular Ca(2+) ([Ca(2+)](i)) transients, and the L-type Ca(2+) current (I(Ca,L)).
Report a problemFND-2061057301
02LabEx vivo tissueMechanism
In isolated adult rat ventricular myocytes, hexarelin and ghrelin increased the amplitude of intracellular Ca2+ transients.
In plain wordsIn isolated rat heart cells, hexarelin and ghrelin increased the calcium signal inside the cells.
Peptide
Hexarelin
Outcome
IncreaseAmplitude of intracellular Ca2+ transients
Study
ratn: not reported in source
Freshly isolated adult Wistar rat ventricular myocytes
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
increased the amplitude of [Ca(2+)](i) transients
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the immediate effects of GHSs on isolated ventricular myocyte shortening, intracellular Ca(2+) ([Ca(2+)](i)) transients, and the L-type Ca(2+) current (I(Ca,L)).
Report a problemFND-2061057302
03LabEx vivo tissueMechanism
In isolated adult rat ventricular myocytes, hexarelin and ghrelin increased the L-type Ca2+ current through the GHS-R1a receptor and a protein kinase C cascade.
In plain wordsIn isolated rat heart cells, hexarelin and ghrelin increased the calcium current into the cells.
Peptide
Hexarelin
Outcome
IncreaseL-type Ca2+ current (I(Ca,L))
Study
ratn: not reported in source
Freshly isolated adult Wistar rat ventricular myocytes
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
increased the amplitude of [Ca(2+)](i) transients and the I(Ca,L).
2 context sentences(design, population, supporting numbers)
Summary · context
hexarelin and ghrelin increase the I(Ca,L), through GHS-R1a receptor and protein kinase C signalling cascade, which contribute to its direct positive inotropic effect on cardiomyocytes.
Summary · context
In the present study, we investigated the immediate effects of GHSs on isolated ventricular myocyte shortening, intracellular Ca(2+) ([Ca(2+)](i)) transients, and the L-type Ca(2+) current (I(Ca,L)).
Report a problemFND-2061057303

Studies that did not test the peptide alone4

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

04LabNot a test of Hexarelin aloneEx vivo tissueMechanism
In isolated rat ventricular myocytes, the GHS-R1a antagonist [D-Lys(3)]-GH-releasing peptide-6 abolished the positive inotropic response to GH secretagogues.
In plain wordsIn isolated rat heart cells, a blocker of the GHS-R1a receptor stopped the stronger contraction caused by these compounds.
Peptide
Hexarelin
Outcome
Not applicableInotropic response blocked by GHS-R1a antagonist
Study
ratn: not reported in source
Freshly isolated adult Wistar rat ventricular myocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
The positive inotropic response was abolished by the GHS-R1a antagonist [D-Lys(3)]-GH-releasing peptide-6 (10 microm).
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the immediate effects of GHSs on isolated ventricular myocyte shortening, intracellular Ca(2+) ([Ca(2+)](i)) transients, and the L-type Ca(2+) current (I(Ca,L)).
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-2061057304
05LabNot a test of Hexarelin aloneEx vivo tissueMechanism
In isolated rat ventricular myocytes, the GHS-R1a antagonist abolished the GH secretagogue-induced increase in the L-type Ca2+ current.
In plain wordsIn isolated rat heart cells, a GHS-R1a blocker stopped the rise in calcium current caused by these compounds.
Peptide
Hexarelin
Outcome
Not applicableI(Ca,L) increase blocked by GHS-R1a antagonist
Study
ratn: not reported in source
Freshly isolated adult Wistar rat ventricular myocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
GHS-induced increase in the I(Ca,L) was abolished by [D-Lys(3)]-GH-releasing peptide-6
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the immediate effects of GHSs on isolated ventricular myocyte shortening, intracellular Ca(2+) ([Ca(2+)](i)) transients, and the L-type Ca(2+) current (I(Ca,L)).
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-2061057305
06LabNot a test of Hexarelin aloneEx vivo tissueMechanism
In isolated rat ventricular myocytes, the protein kinase C inhibitor chelerythrine chloride (5 microm) abolished the GH secretagogue-induced increase in the L-type Ca2+ current.
In plain wordsIn isolated rat heart cells, a protein kinase C blocker stopped the rise in calcium current caused by these compounds.
Peptide
Hexarelin
Outcome
Not applicableI(Ca,L) increase blocked by protein kinase C inhibitor
Study
ratn: not reported in source
Freshly isolated adult Wistar rat ventricular myocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
GHS-induced increase in the I(Ca,L) was abolished by [D-Lys(3)]-GH-releasing peptide-6 and protein kinase C inhibitor, chelerythrine chloride (5 microm)
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the immediate effects of GHSs on isolated ventricular myocyte shortening, intracellular Ca(2+) ([Ca(2+)](i)) transients, and the L-type Ca(2+) current (I(Ca,L)).
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-2061057306
07LabNot a test of Hexarelin aloneEx vivo tissueMechanism
In isolated rat ventricular myocytes, the protein kinase A inhibitor KT 5720 (10 microm) did not abolish the GH secretagogue-induced increase in the L-type Ca2+ current.
In plain wordsIn isolated rat heart cells, a protein kinase A blocker did not stop the rise in calcium current caused by these compounds.
Peptide
Hexarelin
Outcome
No significant changeI(Ca,L) increase with protein kinase A inhibitor
Study
ratn: not reported in source
Freshly isolated adult Wistar rat ventricular myocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
GHS-induced increase in the I(Ca,L) was abolished by [D-Lys(3)]-GH-releasing peptide-6 and protein kinase C inhibitor, chelerythrine chloride (5 microm), but not by protein kinase A inhibitor, KT 5720 (10 microm)
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the immediate effects of GHSs on isolated ventricular myocyte shortening, intracellular Ca(2+) ([Ca(2+)](i)) transients, and the L-type Ca(2+) current (I(Ca,L)).
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-2061057307

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.