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Study · Non-randomized trial · n = 10 · 2010

7 results

Effects of ghrelin, GH-releasing peptide-6 (GHRP-6) and GHRH on GH, ACTH and cortisol release in hyperthyroidism before and after treatment.

Molica P, Nascif SO, Correa-Silva SR, de Sá LB, Vieira JG, Lengyel AM

Pituitary1 Dec 2010Cited by 4 (Europe PMC)

PMID20602173 (opens in a new tab)DOI10.1007/s11102-010-0238-3 (opens in a new tab)PepBankPUB-20602173
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In patients with untreated hyperthyroidism, the peak GH response to GHRP‑6 was lower than in controls.

    In plain wordsIn people with an overactive thyroid, GHRP‑6 raised growth hormone less than in controls.

    Peptide
    GHRP-6
    Outcome
    DecreasePeak GH response to GHRP-6 before treatment versus controls
    Study

    n = 10

    Comparator
    Controls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Peak GH
    13.8 μg/L
    hyperthyroid before treatment
    Peak GH
    25.4 μg/L
    controls

    Source sentences

    Summary
    Peak GH (μg/L; mean ± SE) values after ghrelin (22.6 ± 3.9), GHRP-6 (13.8 ± 2.3) and GHRH (4.9 ± 0.9) were lower in hyperthyroidism before treatment compared to controls (ghrelin: 67.6 ± 19.3; GHRP-6: 25.4 ± 2.7
    1 context sentence
    Summary · context
    We, therefore, evaluated these responses in 10 thyrotoxic patients before treatment and in 7 of them after treatment.
  2. 02HumanNon-randomized trialEfficacy outcome

    In patients with untreated hyperthyroidism, the ACTH response to GHRP‑6 was similar to that of controls.

    In plain wordsIn people with an overactive thyroid, the ACTH response to GHRP‑6 was similar to that of controls.

    Peptide
    GHRP-6
    Outcome
    No significant changeACTH response to GHRP-6 before treatment versus controls
    Study

    n = 10

    Comparator
    Controls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ACTH response to GHRP-6 was similar in both groups (hyperthyroid: 44.7 ± 9.0; controls: 31.3 ± 7.9).
    1 context sentence
    Summary · context
    We, therefore, evaluated these responses in 10 thyrotoxic patients before treatment and in 7 of them after treatment.
  3. 03HumanNon-randomized trialEfficacy outcome

    In patients with untreated hyperthyroidism, the peak cortisol response to GHRP‑6 was comparable to that of controls.

    In plain wordsIn people with an overactive thyroid, the cortisol response to GHRP‑6 was comparable to that of controls.

    Peptide
    GHRP-6
    Outcome
    No significant changePeak cortisol response to GHRP-6 before treatment versus controls
    Study

    n = 10

    Comparator
    Controls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Peak cortisol
    15.9 μg/dL
    hyperthyroid before treatment
    Peak cortisol
    13.5 μg/dL
    controls

    Source sentences

    Summary
    In hyperthyroidism before treatment, peak cortisol (μg/dL) responses to ghrelin (18.2 ± 1.2) and GHRP-6 (15.9 ± 1.4) were comparable to controls (ghrelin: 16.4 ± 1.6; GHRP-6: 13.5 ± 0.9)
    1 context sentence
    Summary · context
    We, therefore, evaluated these responses in 10 thyrotoxic patients before treatment and in 7 of them after treatment.

Studies that did not test the peptide alone4

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 04HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome

    In patients with hyperthyroidism, the peak GH response to GHRP‑6 did not change after 6 months of euthyroidism with treatment.

    In plain wordsIn people with an overactive thyroid, the growth hormone response to GHRP‑6 did not change after 6 months of treatment.

    Peptide
    GHRP-6
    Outcome
    No significant changePeak GH response to GHRP-6 after 6 months of euthyroidism
    Study

    n = 7

    Comparator
    Before treatment
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Peak GH
    15.6 μg/L
    after 6 months of euthyroidism

    Source sentences

    Summary
    did not change after 6 months of euthyroidism (ghrelin: 32.7 ± 4.7; GHRP-6: 15.6 ± 3.6
    2 context sentences
    Title · context
    Effects of ghrelin, GH-releasing peptide-6 (GHRP-6) and GHRH on GH, ACTH and cortisol release in hyperthyroidism before and after treatment.
    Summary · context
    We, therefore, evaluated these responses in 10 thyrotoxic patients before treatment and in 7 of them after treatment.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 05HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome

    After treatment of hyperthyroidism, GH responses to ghrelin, GHRP‑6 and GHRH each increased in about 50% of patients.

    In plain wordsAfter thyroid treatment, the growth hormone response to GHRP‑6 and two other test drugs rose in about half of the patients.

    Peptide
    GHRP-6
    Outcome
    IncreaseProportion of patients with increased GH response after treatment
    Study

    n = 7

    Comparator
    Before treatment
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Patients with increased GH response
    ≈ 50%
    all peptides

    Source sentences

    Summary
    although GH responses to all peptides increased in ~50% of the patients.
    2 context sentences
    Title · context
    Effects of ghrelin, GH-releasing peptide-6 (GHRP-6) and GHRH on GH, ACTH and cortisol release in hyperthyroidism before and after treatment.
    Summary · context
    We, therefore, evaluated these responses in 10 thyrotoxic patients before treatment and in 7 of them after treatment.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 06HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome

    In patients with hyperthyroidism, the ACTH response to GHRP‑6 decreased significantly after 3 months of euthyroidism, with no further change.

    In plain wordsIn people with an overactive thyroid, the ACTH response to GHRP‑6 fell after 3 months of treatment and then stayed the same.

    Peptide
    GHRP-6
    Outcome
    DecreaseACTH response to GHRP-6 after 3 months of euthyroidism
    Study

    n = 7

    Comparator
    Before treatment
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    After 3 months ACTH response to GHRP-6 decreased significantly (20.4 ± 4.2), with no further changes.
    1 context sentence
    Summary · context
    We, therefore, evaluated these responses in 10 thyrotoxic patients before treatment and in 7 of them after treatment.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  4. 07HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome

    In patients with hyperthyroidism, the peak cortisol response to GHRP‑6 did not change after treatment.

    In plain wordsIn people with an overactive thyroid, the cortisol response to GHRP‑6 did not change after treatment.

    Peptide
    GHRP-6
    Outcome
    No significant changePeak cortisol response to GHRP-6 after treatment
    Study

    n = 7

    Comparator
    Before treatment
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    In hyperthyroidism before treatment, peak cortisol (μg/dL) responses to ghrelin (18.2 ± 1.2) and GHRP-6 (15.9 ± 1.4) were comparable to controls (ghrelin: 16.4 ± 1.6; GHRP-6: 13.5 ± 0.9) and no changes were seen after treatment.
    1 context sentence
    Summary · context
    We, therefore, evaluated these responses in 10 thyrotoxic patients before treatment and in 7 of them after treatment.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    12 Oct 2026, 12:58 UTC

    Study results updated

  3. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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