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Study · Animal study (in vivo) · mouse · 2010

5 results

Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of mice.

Luque EM, Carlini VP, Vincenti LM, Puechagut P, Stutz G, Santillán ME, Ruiz RD, Martini AC, Fiol de Cuneo M

Reproduction, fertility, and development1 Jan 2010Cited by 12 (Europe PMC)

PMID20591327 (opens in a new tab)DOI10.1071/rd09231 (opens in a new tab)PepBankPUB-20591327
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In non-pregnant female mice, hexarelin treatment decreased the ovulation rate.

    In plain wordsIn female mice that were not pregnant, hexarelin lowered the ovulation rate.

    Peptide
    Hexarelin
    Outcome
    DecreaseOvulation rate in non-pregnant females
    Study

    mousen: not reported in source

    In vivo, mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 or 200 microg kg(-1) day(-1)As given in this study (mouse).

    Source sentences

    Summary
    Treatment of non-pregnant female mice with HEX decreased ovulation rate.
    1 context sentence
    Summary · context
    hexarelin (HEX; 100 or 200 microg kg(-1) day(-1)), a therapeutic Ghr analogue, on: (1) embryo development 60 h post ovulation, induced pharmacologically, in pregnant mice
  2. 02AnimalAnimal study (in vivo)Other

    In pregnant mice, hexarelin at any time during pregnancy tended to accelerate offspring maturation, regardless of bodyweight.

    In plain wordsIn mice, hexarelin given during pregnancy tended to speed up the maturation of the offspring.

    Peptide
    Hexarelin
    Outcome
    IncreaseOffspring maturation after treatment during pregnancy
    Study

    mousen: not reported in source

    In vivo, mice
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    100 or 200 microg kg(-1) day(-1)As given in this study (mouse).

    Source sentences

    Summary
    However, treatment of pregnant mice with HEX at any time during pregnancy tended to accelerate offspring maturation, regardless of bodyweight.
    1 context sentence
    Summary · context
    hexarelin (HEX; 100 or 200 microg kg(-1) day(-1)), a therapeutic Ghr analogue, on: (1) embryo development 60 h post ovulation, induced pharmacologically, in pregnant mice
  3. 03AnimalAnimal study (in vivo)Other

    In pregnant mice, the acceleration of offspring maturation was significant only for neurobiological parameters after treatment in the first week.

    In plain wordsIn mice, hexarelin in the first week of pregnancy significantly sped up nervous system maturation of the offspring.

    Peptide
    Hexarelin
    Outcome
    IncreaseOffspring neurobiological maturation (first-week treatment)
    Study

    mousen: not reported in source

    In vivo, mice
    Outcome group
    Pregnancy and fetal development · Nervous system and cognition
    Studied dose
    100 or 200 microg kg(-1) day(-1)As given in this study (mouse).

    Source sentences

    Summary
    However, treatment of pregnant mice with HEX at any time during pregnancy tended to accelerate offspring maturation, regardless of bodyweight. This effect was only significant on neurobiological parameters following treatment during the first week.
    1 context sentence
    Summary · context
    hexarelin (HEX; 100 or 200 microg kg(-1) day(-1)), a therapeutic Ghr analogue, on: (1) embryo development 60 h post ovulation, induced pharmacologically, in pregnant mice
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In mice, hexarelin during the first week and/or throughout pregnancy impaired memory acquisition in the offspring, with females more susceptible.

    In plain wordsIn mice, hexarelin given during pregnancy impaired learning in the offspring, and female offspring were more affected.

    Peptide
    Hexarelin
    Outcome
    DecreaseMemory acquisition in offspring
    Study

    mousen: not reported in source

    In vivo, mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    100 or 200 microg kg(-1) day(-1)As given in this study (mouse).

    Source sentences

    Summary
    HEX treatment during the first week and/or throughout the entire pregnancy resulted in impaired memory acquisition in the offspring, with female mice being more susceptible to these effects.
    1 context sentence
    Summary · context
    hexarelin (HEX; 100 or 200 microg kg(-1) day(-1)), a therapeutic Ghr analogue, on: (1) embryo development 60 h post ovulation, induced pharmacologically, in pregnant mice
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In adult mice, chronic hexarelin treatment impaired memory acquisition, similar to the offspring results.

    In plain wordsIn adult mice, long-term hexarelin impaired learning, similar to the effect seen in the offspring.

    Peptide
    Hexarelin
    Outcome
    DecreaseMemory acquisition in adult mice (chronic treatment)
    Study

    mousen: not reported in source

    In vivo, mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    100 or 200 microg kg(-1) day(-1)As given in this study (mouse).

    Source sentences

    Summary
    Similar results were observed for the effects of chronic HEX treatment on memory acquisition in adult mice.
    2 context sentences
    Summary · context
    We also evaluated the effects of chronic HEX administration on memory acquisition in adult mice.
    Summary · context
    hexarelin (HEX; 100 or 200 microg kg(-1) day(-1)), a therapeutic Ghr analogue, on: (1) embryo development 60 h post ovulation, induced pharmacologically, in pregnant mice

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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