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Study · Animal study (in vivo) · mouse · 2010

6 results

Kisspeptin signaling is required for peripheral but not central stimulation of gonadotropin-releasing hormone neurons by NMDA.

d'Anglemont de Tassigny X, Ackroyd KJ, Chatzidaki EE, Colledge WH

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Jun 2010Cited by 55 (Europe PMC)

PMID20573904 (opens in a new tab)PMCIDPMC6634616 (opens in a new tab)DOI10.1523/jneurosci.5486-09.2010 (opens in a new tab)PepBankPUB-20573904
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In mice, kisspeptin‑10 stimulated LH release after central injection.

    In plain wordsIn mice, kisspeptin‑10 injected into the brain stimulated release of luteinizing hormone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH release after central kisspeptin-10 injection
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · central injectionAs given in this study (mouse).

    Source sentences

    Summary
    kisspeptin-10 stimulated LH release after both central and peripheral injection
    1 context sentence
    Summary · context
    To determine whether these agonists act independently or through a common pathway, we have examined their ability to stimulate GnRH/luteinizing hormone (LH) release after peripheral or central administration in Kiss1- or Gpr54 (Kiss1r)-null mutant mice.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In mice, kisspeptin‑10 stimulated LH release after peripheral injection.

    In plain wordsIn mice, kisspeptin‑10 injected outside the brain stimulated release of luteinizing hormone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH release after peripheral kisspeptin-10 injection
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · peripheral injectionAs given in this study (mouse).

    Source sentences

    Summary
    kisspeptin-10 stimulated LH release after both central and peripheral injection
    1 context sentence
    Summary · context
    To determine whether these agonists act independently or through a common pathway, we have examined their ability to stimulate GnRH/luteinizing hormone (LH) release after peripheral or central administration in Kiss1- or Gpr54 (Kiss1r)-null mutant mice.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, kisspeptin‑10 induced c-Fos expression in GnRH neurons after central administration.

    In plain wordsIn mice, kisspeptin‑10 injected into the brain switched on the c-Fos marker in GnRH brain cells.

    Peptide
    Kisspeptin-10
    Outcome
    Increasec-Fos expression in GnRH neurons after central kisspeptin-10
    Study

    mousen: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · central injectionAs given in this study (mouse).

    Source sentences

    Summary
    but induced c-Fos expression in GnRH neurons only after central administration.
    1 context sentence
    Summary · context
    To determine whether these agonists act independently or through a common pathway, we have examined their ability to stimulate GnRH/luteinizing hormone (LH) release after peripheral or central administration in Kiss1- or Gpr54 (Kiss1r)-null mutant mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, kisspeptin‑10 did not induce c-Fos expression in GnRH neurons after peripheral administration.

    In plain wordsIn mice, kisspeptin‑10 injected outside the brain did not switch on the c-Fos marker in GnRH brain cells.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changec-Fos expression in GnRH neurons after peripheral kisspeptin-10
    Study

    mousen: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · peripheral injectionAs given in this study (mouse).

    Source sentences

    Summary
    but induced c-Fos expression in GnRH neurons only after central administration.
    1 context sentence
    Summary · context
    To determine whether these agonists act independently or through a common pathway, we have examined their ability to stimulate GnRH/luteinizing hormone (LH) release after peripheral or central administration in Kiss1- or Gpr54 (Kiss1r)-null mutant mice.

Studies that did not test the peptide alone2

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 05AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Activity measurement

    In prepubertal or gonadally intact Kiss1- or Gpr54-null male mice, peripheral NMDA did not stimulate GnRH/LH release.

    In plain wordsIn male mice lacking kisspeptin signalling, NMDA injected outside the brain did not stimulate LH release. Kisspeptin was not given.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLH release after peripheral NMDA in Kiss1 or Gpr54 mutant mice
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Peripheral injection of NMDA failed to stimulate GnRH/LH release in prepubertal or gonadally intact mutant male mice.
    1 context sentence
    Summary · context
    To determine whether these agonists act independently or through a common pathway, we have examined their ability to stimulate GnRH/luteinizing hormone (LH) release after peripheral or central administration in Kiss1- or Gpr54 (Kiss1r)-null mutant mice.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 06AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Activity measurement

    In Kiss1 and Gpr54 mutant male mice, central NMDA increased plasma LH levels, similar to wild-type mice.

    In plain wordsIn male mice lacking kisspeptin signalling, NMDA injected into the brain raised LH levels as in normal mice. Kisspeptin was not given.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH release after central NMDA in Kiss1 and Gpr54 mutant mice
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    In contrast, central injection of NMDA into the lateral ventricle increased plasma LH levels in both Kiss1 and Gpr54 mutant male mice similar to the responses in wild-type mice.
    1 context sentence
    Summary · context
    To determine whether these agonists act independently or through a common pathway, we have examined their ability to stimulate GnRH/luteinizing hormone (LH) release after peripheral or central administration in Kiss1- or Gpr54 (Kiss1r)-null mutant mice.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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