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Study · Animal study (in vivo) · rhesus monkey · 2010

8 results

Dose combinations of exendin-4 and salmon calcitonin produce additive and synergistic reductions in food intake in nonhuman primates.

Bello NT, Kemm MH, Ofeldt EM, Moran TH

American journal of physiology. Regulatory, integrative and comparative physiology16 Jun 2010Cited by 56 (Europe PMC)

PMID20554932 (opens in a new tab)PMCIDPMC2944427 (opens in a new tab)DOI10.1152/ajpregu.00275.2010 (opens in a new tab)PepBankPUB-20554932
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus monkeys, exendin‑4 with salmon calcitonin reduced food intake more than salmon calcitonin alone.

    In plain wordsIn rhesus monkeys, exendin‑4 with salmon calcitonin reduced food intake more than salmon calcitonin alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseFood intake versus calcitonin alone
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkeys
    Comparator
    Salmon calcitonin alone
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.1, 0.32, or 0.56 microg/kg exendin-4 with salmon calcitonin · intramuscularAs given in this study (rhesus monkey).

    Source sentences

    Summary
    Dose combinations produced reductions in food intake that were significantly greater than those produced by the individual doses.
    2 context sentences
    Summary · context
    This study examined the effects of combined doses of the GLP-1 agonist, exendin-4 (Ex-4), and the amylin analog, salmon calcitonin (sCT), on food intake and meal patterns in adult male rhesus monkeys.
    Summary · context
    Monkeys received intramuscular injections of Ex-4 (0, 0.1, 0.32, or 0.56 microg/kg), sCT (0, 0.1, or 0.32 microg/kg), or combinations thereof before a 6-h daily access to food.

Studies that did not test the peptide alone7

In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Exenatide (exendin-4).

  1. 02AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Efficacy outcome

    In rhesus monkeys, exendin‑4 with salmon calcitonin reduced food intake more than exendin‑4 alone.

    In plain wordsIn rhesus monkeys, exendin‑4 with salmon calcitonin reduced food intake more than exendin‑4 alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseFood intake versus exendin-4 alone
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkeys
    Comparator
    Exendin-4 alone
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Dose combinations produced reductions in food intake that were significantly greater than those produced by the individual doses.
    2 context sentences
    Summary · context
    This study examined the effects of combined doses of the GLP-1 agonist, exendin-4 (Ex-4), and the amylin analog, salmon calcitonin (sCT), on food intake and meal patterns in adult male rhesus monkeys.
    Summary · context
    Monkeys received intramuscular injections of Ex-4 (0, 0.1, 0.32, or 0.56 microg/kg), sCT (0, 0.1, or 0.32 microg/kg), or combinations thereof before a 6-h daily access to food.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  2. 03AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Mechanism

    In rhesus monkeys, exendin‑4 with salmon calcitonin showed early low-dose synergy and later additive effects on food intake.

    In plain wordsIn rhesus monkeys, the combination reduced food intake through early low-dose synergy and later additive effects.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseHourly food intake interaction
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkeys
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Surface plots of the hourly intake indicated a synergistic interaction at lower doses of Ex-4 and sCT during the first 4 h of feeding and additive effects at hours 5 and 6.
    2 context sentences
    Summary · context
    This study examined the effects of combined doses of the GLP-1 agonist, exendin-4 (Ex-4), and the amylin analog, salmon calcitonin (sCT), on food intake and meal patterns in adult male rhesus monkeys.
    Summary · context
    Monkeys received intramuscular injections of Ex-4 (0, 0.1, 0.32, or 0.56 microg/kg), sCT (0, 0.1, or 0.32 microg/kg), or combinations thereof before a 6-h daily access to food.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  3. 04AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Efficacy outcome

    In rhesus monkeys, exendin‑4 with salmon calcitonin reduced average meal size through additive interactions.

    In plain wordsIn rhesus monkeys, exendin‑4 with salmon calcitonin reduced average meal size through additive effects.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseAverage meal size
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkeys
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Meal pattern analysis revealed the combinational doses reduced average meal size and meal frequency by additive interactions, whereas infra-additive effects were apparent at lower doses for first meal size.
    2 context sentences
    Summary · context
    This study examined the effects of combined doses of the GLP-1 agonist, exendin-4 (Ex-4), and the amylin analog, salmon calcitonin (sCT), on food intake and meal patterns in adult male rhesus monkeys.
    Summary · context
    Monkeys received intramuscular injections of Ex-4 (0, 0.1, 0.32, or 0.56 microg/kg), sCT (0, 0.1, or 0.32 microg/kg), or combinations thereof before a 6-h daily access to food.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  4. 05AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Efficacy outcome

    In rhesus monkeys, exendin‑4 with salmon calcitonin reduced meal frequency through additive interactions.

    In plain wordsIn rhesus monkeys, exendin‑4 with salmon calcitonin reduced meal frequency through additive effects.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMeal frequency
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkeys
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Meal pattern analysis revealed the combinational doses reduced average meal size and meal frequency by additive interactions, whereas infra-additive effects were apparent at lower doses for first meal size.
    2 context sentences
    Summary · context
    This study examined the effects of combined doses of the GLP-1 agonist, exendin-4 (Ex-4), and the amylin analog, salmon calcitonin (sCT), on food intake and meal patterns in adult male rhesus monkeys.
    Summary · context
    Monkeys received intramuscular injections of Ex-4 (0, 0.1, 0.32, or 0.56 microg/kg), sCT (0, 0.1, or 0.32 microg/kg), or combinations thereof before a 6-h daily access to food.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  5. 06AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Efficacy outcome

    In rhesus monkeys, lower doses of exendin‑4 with salmon calcitonin showed infra-additive effects on first meal size.

    In plain wordsIn rhesus monkeys, lower combination doses had less-than-additive effects on first meal size.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseFirst meal size interaction
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkeys
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Meal pattern analysis revealed the combinational doses reduced average meal size and meal frequency by additive interactions, whereas infra-additive effects were apparent at lower doses for first meal size.
    2 context sentences
    Summary · context
    This study examined the effects of combined doses of the GLP-1 agonist, exendin-4 (Ex-4), and the amylin analog, salmon calcitonin (sCT), on food intake and meal patterns in adult male rhesus monkeys.
    Summary · context
    Monkeys received intramuscular injections of Ex-4 (0, 0.1, 0.32, or 0.56 microg/kg), sCT (0, 0.1, or 0.32 microg/kg), or combinations thereof before a 6-h daily access to food.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  6. 07AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Efficacy outcome

    In rhesus monkeys, repeated exendin‑4 with salmon calcitonin reduced daily food intake by more than 70% versus saline baseline for 5 days.

    In plain wordsIn rhesus monkeys, the combination reduced daily food intake by more than 70% versus saline baseline for 5 days.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseDaily food intake during repeated treatment
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkeys
    Comparator
    Saline baseline
    Outcome group
    Appetite and food intake · Metabolic and weight

    Measurements

    Food intake reduction
    > 70%
    versus saline baseline during repeated combination treatment

    Source sentences

    Summary
    This resulted in sustained reductions in daily food intake (>70% from saline baseline) for 5 days with residual reductions ( approximately 48% from saline baseline) persisting on day 1 following the injections.
    3 context sentences
    Summary · context
    Combinational doses were further characterized by administration of repeated daily injections of 0.56 microg/kg Ex-4 + 0.32 microg/kg sCT for 5 days.
    Summary · context
    This study examined the effects of combined doses of the GLP-1 agonist, exendin-4 (Ex-4), and the amylin analog, salmon calcitonin (sCT), on food intake and meal patterns in adult male rhesus monkeys.
    Summary · context
    Monkeys received intramuscular injections of Ex-4 (0, 0.1, 0.32, or 0.56 microg/kg), sCT (0, 0.1, or 0.32 microg/kg), or combinations thereof before a 6-h daily access to food.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  7. 08AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Efficacy outcome

    In rhesus monkeys, food intake remained approximately 48% below saline baseline on the first day after repeated combination injections.

    In plain wordsIn rhesus monkeys, food intake remained approximately 48% below saline baseline the day after combination injections stopped.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseResidual food intake reduction
    Study

    rhesus monkeyn: not reported in source

    Adult male rhesus monkeys
    Comparator
    Saline baseline
    Outcome group
    Appetite and food intake · Metabolic and weight

    Measurements

    Residual food intake reduction
    ≈ 48%
    day 1 after combination injections

    Source sentences

    Summary
    This resulted in sustained reductions in daily food intake (>70% from saline baseline) for 5 days with residual reductions ( approximately 48% from saline baseline) persisting on day 1 following the injections.
    3 context sentences
    Summary · context
    Combinational doses were further characterized by administration of repeated daily injections of 0.56 microg/kg Ex-4 + 0.32 microg/kg sCT for 5 days.
    Summary · context
    This study examined the effects of combined doses of the GLP-1 agonist, exendin-4 (Ex-4), and the amylin analog, salmon calcitonin (sCT), on food intake and meal patterns in adult male rhesus monkeys.
    Summary · context
    Monkeys received intramuscular injections of Ex-4 (0, 0.1, 0.32, or 0.56 microg/kg), sCT (0, 0.1, or 0.32 microg/kg), or combinations thereof before a 6-h daily access to food.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    22 Oct 2026, 02:26 UTC

    Study results updated

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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