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Study · Randomized controlled trial · n = 60 · 2012

5 results

Glutathione as an oral whitening agent: a randomized, double-blind, placebo-controlled study.

Arjinpathana N, Asawanonda P

The Journal of dermatological treatment5 Jun 2010Cited by 62 (Europe PMC)

PMID20524875 (opens in a new tab)DOI10.3109/09546631003801619 (opens in a new tab)PepBankPUB-20524875
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy medical students, glutathione reduced right facial melanin index more than placebo.

    In plain wordsIn healthy medical students, glutathione reduced skin melanin on the right face more than placebo.

    Peptide
    Glutathione
    Outcome
    DecreaseRight facial melanin index
    Study

    n = 60

    Comparator
    Placebo
    Analysis
    Primary
    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    500 mg/day in two divided doses · oral · 4 weeksAs given in this study (human).

    Measurements

    P value
    0.021
    right side of face

    Source sentences

    Summary
    The reductions were statistically significantly greater than those receiving placebo at two sites, namely the right side of the face and the sun-exposed left forearm (p-values = 0.021 and 0.036, respectively).
    2 context sentences
    Summary · context
    This randomized, double-blind, two-arm, placebo-controlled study was set in the King Chulalongkorn Memorial Hospital, Bangkok, Thailand, a teaching hospital affiliated with a medical school.
    Summary · context
    Sixty otherwise healthy medical students were randomized to receive either glutathione capsules, 500 mg/day in two divided doses, or placebo for 4 weeks.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy medical students, glutathione reduced sun-exposed left forearm melanin index more than placebo.

    In plain wordsIn healthy medical students, glutathione reduced skin melanin on the sun-exposed left forearm more than placebo.

    Peptide
    Glutathione
    Outcome
    DecreaseSun-exposed left forearm melanin index
    Study

    n = 60

    Comparator
    Placebo
    Analysis
    Primary
    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    500 mg/day in two divided doses · oral · 4 weeksAs given in this study (human).

    Measurements

    P value
    0.036
    sun-exposed left forearm

    Source sentences

    Summary
    The reductions were statistically significantly greater than those receiving placebo at two sites, namely the right side of the face and the sun-exposed left forearm (p-values = 0.021 and 0.036, respectively).
    2 context sentences
    Summary · context
    This randomized, double-blind, two-arm, placebo-controlled study was set in the King Chulalongkorn Memorial Hospital, Bangkok, Thailand, a teaching hospital affiliated with a medical school.
    Summary · context
    Sixty otherwise healthy medical students were randomized to receive either glutathione capsules, 500 mg/day in two divided doses, or placebo for 4 weeks.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy medical students, melanin indices decreased from baseline at all six measured sites after 4 weeks of glutathione.

    In plain wordsIn healthy medical students, skin melanin indices fell from baseline at all six measured sites after 4 weeks of oral glutathione.

    Peptide
    Glutathione
    Outcome
    DecreaseMelanin indices at all six sites
    Study

    n: not reported in source

    Analysis
    Primary
    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    500 mg/day in two divided doses · oral · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    At 4 weeks, the melanin indices decreased consistently at all six sites in subjects who received glutathione.
    2 context sentences
    Summary · context
    This randomized, double-blind, two-arm, placebo-controlled study was set in the King Chulalongkorn Memorial Hospital, Bangkok, Thailand, a teaching hospital affiliated with a medical school.
    Summary · context
    Sixty otherwise healthy medical students were randomized to receive either glutathione capsules, 500 mg/day in two divided doses, or placebo for 4 weeks.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In healthy medical students, UV spot changes similarly reflected the greater melanin reductions with glutathione than placebo.

    In plain wordsIn healthy medical students, UV spot changes similarly reflected greater skin melanin reductions with glutathione than placebo.

    Peptide
    Glutathione
    Outcome
    DecreaseUV spot number
    Study

    n = 60

    Comparator
    Placebo
    Analysis
    Secondary
    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    500 mg/day in two divided doses · oral · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    This was similarly reflected in the changes in the number of UV spots, as measured by VISIA.
    3 context sentences
    Summary · context
    The reductions were statistically significantly greater than those receiving placebo at two sites, namely the right side of the face and the sun-exposed left forearm (p-values = 0.021 and 0.036, respectively).
    Summary · context
    This randomized, double-blind, two-arm, placebo-controlled study was set in the King Chulalongkorn Memorial Hospital, Bangkok, Thailand, a teaching hospital affiliated with a medical school.
    Summary · context
    Sixty otherwise healthy medical students were randomized to receive either glutathione capsules, 500 mg/day in two divided doses, or placebo for 4 weeks.
  5. 05HumanRandomized controlled trialSafety outcome

    In healthy medical students, both glutathione and placebo were very well tolerated.

    In plain wordsIn healthy medical students, both glutathione and placebo were very well tolerated.

    Peptide
    Glutathione
    Outcome
    Not applicableTolerability
    Study

    n = 60

    Comparator
    Placebo
    Outcome group
    Adverse events · Whole body
    Studied dose
    500 mg/day in two divided doses · oral · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    Both glutathione and placebo were very well tolerated.
    2 context sentences
    Summary · context
    This randomized, double-blind, two-arm, placebo-controlled study was set in the King Chulalongkorn Memorial Hospital, Bangkok, Thailand, a teaching hospital affiliated with a medical school.
    Summary · context
    Sixty otherwise healthy medical students were randomized to receive either glutathione capsules, 500 mg/day in two divided doses, or placebo for 4 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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