Direct and indirect effects of kisspeptin on liver oxidant and antioxidant systems in young male rats.

Aydin M, Oktar S, Yonden Z, Ozturk OH, Yilmaz B

Cell biochemistry and function1 Jun 2010Cited by 32 (Europe PMC)

PMID20517893DOI10.1002/cbf.1656PepBankPUB-20517893

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In young male rats, kisspeptin‑10 for 7 days increased liver SOD activity.
In plain wordsIn young male rats, kisspeptin‑10 raised the activity of an antioxidant enzyme in the liver.
Peptide
Kisspeptin-10
Outcome
IncreaseLiver superoxide dismutase activity
Study
ratn: not reported in source
young male rats
Comparator
Control (saline)
Outcome group
Oxidative stress · Liver
Studied dose
20 nmol/rat/day · 7 daysAs given in this study (rat).
Source sentences
Summary
Kisspeptin increased the activities of SOD and catalase (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-four rats were divided into four groups (n = 6/group).
Summary · context
Kisspeptin-10 was administered to the animals in the second group (20 nmol/rat/day), for a period of 7 days.
Report a problemFND-2051789301
02AnimalAnimal study (in vivo)Efficacy outcome
In young male rats, kisspeptin‑10 for 7 days increased liver catalase activity.
In plain wordsIn young male rats, kisspeptin‑10 raised the activity of an antioxidant enzyme in the liver.
Peptide
Kisspeptin-10
Outcome
IncreaseLiver catalase activity
Study
ratn: not reported in source
young male rats
Comparator
Control (saline)
Outcome group
Oxidative stress · Liver
Studied dose
20 nmol/rat/day · 7 daysAs given in this study (rat).
Source sentences
Summary
Kisspeptin increased the activities of SOD and catalase (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-four rats were divided into four groups (n = 6/group).
Summary · context
Kisspeptin-10 was administered to the animals in the second group (20 nmol/rat/day), for a period of 7 days.
Report a problemFND-2051789302

Studies that did not test the peptide alone7

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

03AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome
In young male rats, liver malondialdehyde was lower than control in the kisspeptin‑10, goserelin and combined groups taken together.
In plain wordsIn young male rats, a liver stress marker was lower than in controls across the three treated groups, not for kisspeptin alone.
Peptide
Kisspeptin-10
Outcome
DecreaseLiver malondialdehyde in treated groups
Study
ratn: not reported in source
young male rats
Comparator
Control
Outcome group
Oxidative stress · Liver
Source sentences
Summary
When compared to the control group, the levels of malondialdehyde, TOS and AST were lower, but levels of BUN, cholesterole, HDL and AD were higher in the other three groups (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-four rats were divided into four groups (n = 6/group).
Summary · context
Kisspeptin-10 was administered to the animals in the second group (20 nmol/rat/day), for a period of 7 days.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2051789303
04AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome
In young male rats, serum total oxidant status was lower than control in the kisspeptin‑10, goserelin and combined groups taken together.
In plain wordsIn young male rats, a blood oxidant measure was lower than in controls across the three treated groups, not for kisspeptin alone.
Peptide
Kisspeptin-10
Outcome
DecreaseSerum total oxidant status in treated groups
Study
ratn: not reported in source
young male rats
Comparator
Control
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
When compared to the control group, the levels of malondialdehyde, TOS and AST were lower, but levels of BUN, cholesterole, HDL and AD were higher in the other three groups (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-four rats were divided into four groups (n = 6/group).
Summary · context
Kisspeptin-10 was administered to the animals in the second group (20 nmol/rat/day), for a period of 7 days.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2051789304
05AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Safety outcome
In young male rats, serum AST was lower than control in the kisspeptin‑10, goserelin and combined groups taken together.
In plain wordsIn young male rats, a liver enzyme in blood was lower than in controls across the three treated groups, not for kisspeptin alone.
Peptide
Kisspeptin-10
Outcome
DecreaseSerum AST in treated groups
Study
ratn: not reported in source
young male rats
Comparator
Control
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
When compared to the control group, the levels of malondialdehyde, TOS and AST were lower, but levels of BUN, cholesterole, HDL and AD were higher in the other three groups (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-four rats were divided into four groups (n = 6/group).
Summary · context
Kisspeptin-10 was administered to the animals in the second group (20 nmol/rat/day), for a period of 7 days.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2051789305
06AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Safety outcome
In young male rats, serum BUN was higher than control in the kisspeptin‑10, goserelin and combined groups taken together.
In plain wordsIn young male rats, a kidney-related blood marker was higher than in controls across the three treated groups, not for kisspeptin alone.
Peptide
Kisspeptin-10
Outcome
IncreaseSerum blood urea nitrogen in treated groups
Study
ratn: not reported in source
young male rats
Comparator
Control
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
When compared to the control group, the levels of malondialdehyde, TOS and AST were lower, but levels of BUN, cholesterole, HDL and AD were higher in the other three groups (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-four rats were divided into four groups (n = 6/group).
Summary · context
Kisspeptin-10 was administered to the animals in the second group (20 nmol/rat/day), for a period of 7 days.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2051789306
07AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Safety outcome
In young male rats, serum cholesterol was higher than control in the kisspeptin‑10, goserelin and combined groups taken together.
In plain wordsIn young male rats, blood cholesterol was higher than in controls across the three treated groups, not for kisspeptin alone.
Peptide
Kisspeptin-10
Outcome
IncreaseSerum cholesterol in treated groups
Study
ratn: not reported in source
young male rats
Comparator
Control
Outcome group
Lipids · Metabolic and weight
Source sentences
Summary
When compared to the control group, the levels of malondialdehyde, TOS and AST were lower, but levels of BUN, cholesterole, HDL and AD were higher in the other three groups (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-four rats were divided into four groups (n = 6/group).
Summary · context
Kisspeptin-10 was administered to the animals in the second group (20 nmol/rat/day), for a period of 7 days.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2051789307
08AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Safety outcome
In young male rats, serum HDL was higher than control in the kisspeptin‑10, goserelin and combined groups taken together.
In plain wordsIn young male rats, blood HDL cholesterol was higher than in controls across the three treated groups, not for kisspeptin alone.
Peptide
Kisspeptin-10
Outcome
IncreaseSerum HDL in treated groups
Study
ratn: not reported in source
young male rats
Comparator
Control
Outcome group
Lipids · Metabolic and weight
Source sentences
Summary
When compared to the control group, the levels of malondialdehyde, TOS and AST were lower, but levels of BUN, cholesterole, HDL and AD were higher in the other three groups (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-four rats were divided into four groups (n = 6/group).
Summary · context
Kisspeptin-10 was administered to the animals in the second group (20 nmol/rat/day), for a period of 7 days.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2051789308
09AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome
In young male rats, adenosine deaminase was higher than control in the kisspeptin‑10, goserelin and combined groups taken together.
In plain wordsIn young male rats, an enzyme measure was higher than in controls across the three treated groups, not for kisspeptin alone.
Peptide
Kisspeptin-10
Outcome
IncreaseLiver adenosine deaminase in treated groups
Study
ratn: not reported in source
young male rats
Comparator
Control
Outcome group
Oxidative stress · Liver
Source sentences
Summary
When compared to the control group, the levels of malondialdehyde, TOS and AST were lower, but levels of BUN, cholesterole, HDL and AD were higher in the other three groups (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-four rats were divided into four groups (n = 6/group).
Summary · context
Kisspeptin-10 was administered to the animals in the second group (20 nmol/rat/day), for a period of 7 days.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2051789309

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.