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Study · Animal study (in vivo) · rat · 2010

9 results

Exenatide reduces food intake and activates the enteric nervous system of the gastrointestinal tract and the dorsal vagal complex of the hindbrain in the rat by a GLP-1 receptor.

Washington MC, Raboin SJ, Thompson W, Larsen CJ, Sayegh AI

Brain research7 May 2010Cited by 46 (Europe PMC)

PMID20452329 (opens in a new tab)DOI10.1016/j.brainres.2010.05.002 (opens in a new tab)PepBankPUB-20452329
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In food-deprived rats, all tested exenatide doses reduced sucrose intake versus saline after the 20 min time point.

    In plain wordsIn rats without food overnight, all tested exenatide doses reduced sucrose intake versus saline after 20 min.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseSucrose intake
    Study

    ratn: not reported in source

    Overnight food-deprived male Sprague Dawley rats
    Comparator
    Saline
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.1, 0.5, 5 and 10 microg/kg · intraperitoneal · 120 min observationAs given in this study (rat).

    Source sentences

    Summary
    All doses of exenatide reduced sucrose intake following the 20 min time point, and pretreatment with exendin (9-39), a GLP-1 receptor antagonist, reversed this reduction.
    3 context sentences
    Summary · context
    EXPERIMENT 1: Five groups of overnight food-deprived male Sprague Dawley rats were injected with exenatide (0.1, 0.5, 5 and 10 microg/kg) or saline intraperitoneally, and the intake of 10% sucrose solution was measured at 5 min intervals for 120 min.
    Summary · context
    EXPERIMENTS 2 AND 3: Following overnight food deprivation, five groups of rats were injected with the treatments listed above and sacrificed 90 min following the injections.
    Summary · context
    The myenteric and submucosal plexuses and DVC were processed for detection of Fos-like immunoreactivity (Fos-LI; a marker for neuronal activation).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In food-deprived rats, exenatide increased Fos-LI in duodenal myenteric neurons dose-dependently versus saline.

    In plain wordsIn rats without food overnight, exenatide increased a nerve activation marker in duodenal myenteric neurons versus saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseDuodenal myenteric neuronal Fos-LI
    Study

    ratn: not reported in source

    Overnight food-deprived male Sprague Dawley rats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    0.1, 0.5, 5 and 10 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Exenatide increased Fos-LI dose-dependently in the myenteric and submucosal neurons of the duodenum, but not jejunum and ileum, and in the areas of the DVC that regulate food intake e.g. area postrema, nucleus tractus solitaries and dorsal motor nucleus of the vagus.
    3 context sentences
    Summary · context
    EXPERIMENT 1: Five groups of overnight food-deprived male Sprague Dawley rats were injected with exenatide (0.1, 0.5, 5 and 10 microg/kg) or saline intraperitoneally, and the intake of 10% sucrose solution was measured at 5 min intervals for 120 min.
    Summary · context
    EXPERIMENTS 2 AND 3: Following overnight food deprivation, five groups of rats were injected with the treatments listed above and sacrificed 90 min following the injections.
    Summary · context
    The myenteric and submucosal plexuses and DVC were processed for detection of Fos-like immunoreactivity (Fos-LI; a marker for neuronal activation).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In food-deprived rats, exenatide increased Fos-LI in duodenal submucosal neurons dose-dependently versus saline.

    In plain wordsIn rats without food overnight, exenatide increased a nerve activation marker in duodenal submucosal neurons versus saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseDuodenal submucosal neuronal Fos-LI
    Study

    ratn: not reported in source

    Overnight food-deprived male Sprague Dawley rats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    0.1, 0.5, 5 and 10 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Exenatide increased Fos-LI dose-dependently in the myenteric and submucosal neurons of the duodenum, but not jejunum and ileum, and in the areas of the DVC that regulate food intake e.g. area postrema, nucleus tractus solitaries and dorsal motor nucleus of the vagus.
    3 context sentences
    Summary · context
    EXPERIMENT 1: Five groups of overnight food-deprived male Sprague Dawley rats were injected with exenatide (0.1, 0.5, 5 and 10 microg/kg) or saline intraperitoneally, and the intake of 10% sucrose solution was measured at 5 min intervals for 120 min.
    Summary · context
    EXPERIMENTS 2 AND 3: Following overnight food deprivation, five groups of rats were injected with the treatments listed above and sacrificed 90 min following the injections.
    Summary · context
    The myenteric and submucosal plexuses and DVC were processed for detection of Fos-like immunoreactivity (Fos-LI; a marker for neuronal activation).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In food-deprived rats, exenatide did not increase jejunal neuronal Fos-LI versus saline.

    In plain wordsIn rats without food overnight, exenatide did not increase the nerve activation marker in the jejunum versus saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    No significant changeJejunal neuronal Fos-LI
    Study

    ratn: not reported in source

    Overnight food-deprived male Sprague Dawley rats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    0.1, 0.5, 5 and 10 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Exenatide increased Fos-LI dose-dependently in the myenteric and submucosal neurons of the duodenum, but not jejunum and ileum, and in the areas of the DVC that regulate food intake e.g. area postrema, nucleus tractus solitaries and dorsal motor nucleus of the vagus.
    3 context sentences
    Summary · context
    EXPERIMENT 1: Five groups of overnight food-deprived male Sprague Dawley rats were injected with exenatide (0.1, 0.5, 5 and 10 microg/kg) or saline intraperitoneally, and the intake of 10% sucrose solution was measured at 5 min intervals for 120 min.
    Summary · context
    EXPERIMENTS 2 AND 3: Following overnight food deprivation, five groups of rats were injected with the treatments listed above and sacrificed 90 min following the injections.
    Summary · context
    The myenteric and submucosal plexuses and DVC were processed for detection of Fos-like immunoreactivity (Fos-LI; a marker for neuronal activation).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In food-deprived rats, exenatide did not increase ileal neuronal Fos-LI versus saline.

    In plain wordsIn rats without food overnight, exenatide did not increase the nerve activation marker in the ileum versus saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    No significant changeIleal neuronal Fos-LI
    Study

    ratn: not reported in source

    Overnight food-deprived male Sprague Dawley rats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    0.1, 0.5, 5 and 10 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Exenatide increased Fos-LI dose-dependently in the myenteric and submucosal neurons of the duodenum, but not jejunum and ileum, and in the areas of the DVC that regulate food intake e.g. area postrema, nucleus tractus solitaries and dorsal motor nucleus of the vagus.
    3 context sentences
    Summary · context
    EXPERIMENT 1: Five groups of overnight food-deprived male Sprague Dawley rats were injected with exenatide (0.1, 0.5, 5 and 10 microg/kg) or saline intraperitoneally, and the intake of 10% sucrose solution was measured at 5 min intervals for 120 min.
    Summary · context
    EXPERIMENTS 2 AND 3: Following overnight food deprivation, five groups of rats were injected with the treatments listed above and sacrificed 90 min following the injections.
    Summary · context
    The myenteric and submucosal plexuses and DVC were processed for detection of Fos-like immunoreactivity (Fos-LI; a marker for neuronal activation).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In food-deprived rats, exenatide increased Fos-LI dose-dependently in food-intake-regulating areas of the dorsal vagal complex versus saline.

    In plain wordsIn rats without food overnight, exenatide increased a nerve activation marker in brain regions that regulate eating versus saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseDorsal vagal complex Fos-LI
    Study

    ratn: not reported in source

    Overnight food-deprived male Sprague Dawley rats
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0.1, 0.5, 5 and 10 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Exenatide increased Fos-LI dose-dependently in the myenteric and submucosal neurons of the duodenum, but not jejunum and ileum, and in the areas of the DVC that regulate food intake e.g. area postrema, nucleus tractus solitaries and dorsal motor nucleus of the vagus.
    3 context sentences
    Summary · context
    EXPERIMENT 1: Five groups of overnight food-deprived male Sprague Dawley rats were injected with exenatide (0.1, 0.5, 5 and 10 microg/kg) or saline intraperitoneally, and the intake of 10% sucrose solution was measured at 5 min intervals for 120 min.
    Summary · context
    EXPERIMENTS 2 AND 3: Following overnight food deprivation, five groups of rats were injected with the treatments listed above and sacrificed 90 min following the injections.
    Summary · context
    The myenteric and submucosal plexuses and DVC were processed for detection of Fos-like immunoreactivity (Fos-LI; a marker for neuronal activation).

Studies that did not test the peptide alone3

In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Exenatide (exendin-4).

  1. 07AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Mechanism

    In food-deprived rats, exendin (9-39) pretreatment reversed the exenatide-associated reduction in sucrose intake.

    In plain wordsIn rats without food overnight, the receptor blocker reversed the reduction in sucrose intake seen with exenatide alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseAntagonist reversal of reduced sucrose intake
    Study

    ratn: not reported in source

    Overnight food-deprived male Sprague Dawley rats
    Comparator
    Exenatide without exendin (9-39)
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    All doses of exenatide reduced sucrose intake following the 20 min time point, and pretreatment with exendin (9-39), a GLP-1 receptor antagonist, reversed this reduction.
    3 context sentences
    Summary · context
    EXPERIMENT 1: Five groups of overnight food-deprived male Sprague Dawley rats were injected with exenatide (0.1, 0.5, 5 and 10 microg/kg) or saline intraperitoneally, and the intake of 10% sucrose solution was measured at 5 min intervals for 120 min.
    Summary · context
    EXPERIMENTS 2 AND 3: Following overnight food deprivation, five groups of rats were injected with the treatments listed above and sacrificed 90 min following the injections.
    Summary · context
    The myenteric and submucosal plexuses and DVC were processed for detection of Fos-like immunoreactivity (Fos-LI; a marker for neuronal activation).

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  2. 08AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Mechanism

    In food-deprived rats, exendin (9-39) pretreatment blocked exenatide-associated enteric neuronal activation.

    In plain wordsIn rats without food overnight, the receptor blocker prevented gut nerve activation seen with exenatide alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseAntagonist blockade of enteric neuronal activation
    Study

    ratn: not reported in source

    Overnight food-deprived male Sprague Dawley rats
    Comparator
    Exenatide without exendin (9-39)
    Outcome group
    Receptor activity and mechanism · Gastrointestinal

    Source sentences

    Summary
    In addition, pretreatment with exendin (9-39) prior to exenatide injection blocked the activation in both locations.
    4 context sentences
    Summary · context
    Exenatide increased Fos-LI dose-dependently in the myenteric and submucosal neurons of the duodenum, but not jejunum and ileum, and in the areas of the DVC that regulate food intake e.g. area postrema, nucleus tractus solitaries and dorsal motor nucleus of the vagus.
    Summary · context
    EXPERIMENT 1: Five groups of overnight food-deprived male Sprague Dawley rats were injected with exenatide (0.1, 0.5, 5 and 10 microg/kg) or saline intraperitoneally, and the intake of 10% sucrose solution was measured at 5 min intervals for 120 min.
    Summary · context
    EXPERIMENTS 2 AND 3: Following overnight food deprivation, five groups of rats were injected with the treatments listed above and sacrificed 90 min following the injections.
    Summary · context
    The myenteric and submucosal plexuses and DVC were processed for detection of Fos-like immunoreactivity (Fos-LI; a marker for neuronal activation).

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  3. 09AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Mechanism

    In food-deprived rats, exendin (9-39) pretreatment blocked exenatide-associated dorsal vagal complex activation.

    In plain wordsIn rats without food overnight, the receptor blocker prevented brain nerve activation seen with exenatide alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseAntagonist blockade of dorsal vagal complex activation
    Study

    ratn: not reported in source

    Overnight food-deprived male Sprague Dawley rats
    Comparator
    Exenatide without exendin (9-39)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In addition, pretreatment with exendin (9-39) prior to exenatide injection blocked the activation in both locations.
    4 context sentences
    Summary · context
    Exenatide increased Fos-LI dose-dependently in the myenteric and submucosal neurons of the duodenum, but not jejunum and ileum, and in the areas of the DVC that regulate food intake e.g. area postrema, nucleus tractus solitaries and dorsal motor nucleus of the vagus.
    Summary · context
    EXPERIMENT 1: Five groups of overnight food-deprived male Sprague Dawley rats were injected with exenatide (0.1, 0.5, 5 and 10 microg/kg) or saline intraperitoneally, and the intake of 10% sucrose solution was measured at 5 min intervals for 120 min.
    Summary · context
    EXPERIMENTS 2 AND 3: Following overnight food deprivation, five groups of rats were injected with the treatments listed above and sacrificed 90 min following the injections.
    Summary · context
    The myenteric and submucosal plexuses and DVC were processed for detection of Fos-like immunoreactivity (Fos-LI; a marker for neuronal activation).

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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