Effect of peripheral kisspeptin administration on adiponectin, leptin, and resistin secretion under fed and fasting conditions in the adult male rhesus monkey (Macaca mulatta).

Wahab F, Bano R, Jabeen S, Irfan S, Shahab M

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme5 May 2010Cited by 26 (Europe PMC)

PMID20446240DOI10.1055/s-0030-1252016PepBankPUB-20446240

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In adult male rhesus monkeys under fed conditions, peripheral kisspeptin significantly increased mean plasma adiponectin versus pretreatment or vehicle.
In plain wordsIn monkeys, kisspeptin raised blood adiponectin when fed, compared with before treatment or with vehicle.
Peptide
Kisspeptin-10
Outcome
IncreasePlasma adiponectin under fed conditions
Study
rhesus monkeyn = 4
adult male rhesus monkeys (Macaca mulatta)
Comparator
Pretreatment or vehicle
Outcome group
Hormone levels · Metabolic and weight
Studied dose
Dose not stated · peripheralAs given in this study (rhesus monkey).
Source sentences
Summary
Kisspeptin administration significantly increased (p<0.05) mean plasma adiponectin levels under fed and 24-h fasting conditions as compared to pretreatment or vehicle-treatment levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, in the present study the effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin, leptin, and resistin in a set of four chair-restraint habituated intact adult male rhesus monkeys under; 1) normal fed conditions, 2) 24-h fasting cond…
Report a problemFND-2044624001
02AnimalAnimal study (in vivo)Efficacy outcome
In adult male rhesus monkeys under 24-h fasting, peripheral kisspeptin significantly increased mean plasma adiponectin versus pretreatment or vehicle.
In plain wordsIn monkeys, kisspeptin raised blood adiponectin after 24 hours of fasting, compared with before treatment or with vehicle.
Peptide
Kisspeptin-10
Outcome
IncreasePlasma adiponectin under 24-h fasting
Study
rhesus monkeyn = 4
adult male rhesus monkeys (Macaca mulatta)
Comparator
Pretreatment or vehicle
Outcome group
Hormone levels · Metabolic and weight
Studied dose
Dose not stated · peripheralAs given in this study (rhesus monkey).
Source sentences
Summary
Kisspeptin administration significantly increased (p<0.05) mean plasma adiponectin levels under fed and 24-h fasting conditions as compared to pretreatment or vehicle-treatment levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, in the present study the effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin, leptin, and resistin in a set of four chair-restraint habituated intact adult male rhesus monkeys under; 1) normal fed conditions, 2) 24-h fasting cond…
Report a problemFND-2044624002
03AnimalAnimal study (in vivo)Efficacy outcome
In adult male rhesus monkeys under 48-h fasting, the stimulatory effect of kisspeptin on plasma adiponectin lacked statistical significance.
In plain wordsIn monkeys, kisspeptin did not change blood adiponectin significantly after 48 hours of fasting.
Peptide
Kisspeptin-10
Outcome
No significant changePlasma adiponectin under 48-h fasting
Study
rhesus monkeyn = 4
adult male rhesus monkeys (Macaca mulatta)
Comparator
Pretreatment or vehicle
Outcome group
Hormone levels · Metabolic and weight
Studied dose
Dose not stated · peripheralAs given in this study (rhesus monkey).
Source sentences
Summary
A stimulatory effect was also observed on the 48-h fasting stimulated plasma adiponectin levels, but it lacked statistical significance.
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, in the present study the effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin, leptin, and resistin in a set of four chair-restraint habituated intact adult male rhesus monkeys under; 1) normal fed conditions, 2) 24-h fasting cond…
Report a problemFND-2044624003
04AnimalAnimal study (in vivo)Efficacy outcome
In adult male rhesus monkeys, kisspeptin had no effect on mean plasma leptin.
In plain wordsIn monkeys, kisspeptin did not change blood leptin.
Peptide
Kisspeptin-10
Outcome
No significant changePlasma leptin
Study
rhesus monkeyn = 4
adult male rhesus monkeys (Macaca mulatta)
Comparator
Pretreatment or vehicle
Outcome group
Hormone levels · Metabolic and weight
Studied dose
Dose not stated · peripheralAs given in this study (rhesus monkey).
Source sentences
Summary
In contrast, no effect of kisspeptin was observed on mean plasma leptin and resistin
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, in the present study the effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin, leptin, and resistin in a set of four chair-restraint habituated intact adult male rhesus monkeys under; 1) normal fed conditions, 2) 24-h fasting cond…
Report a problemFND-2044624004
05AnimalAnimal study (in vivo)Efficacy outcome
In adult male rhesus monkeys, kisspeptin had no effect on mean plasma resistin.
In plain wordsIn monkeys, kisspeptin did not change blood resistin.
Peptide
Kisspeptin-10
Outcome
No significant changePlasma resistin
Study
rhesus monkeyn = 4
adult male rhesus monkeys (Macaca mulatta)
Comparator
Pretreatment or vehicle
Outcome group
Hormone levels · Metabolic and weight
Studied dose
Dose not stated · peripheralAs given in this study (rhesus monkey).
Source sentences
Summary
In contrast, no effect of kisspeptin was observed on mean plasma leptin and resistin
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, in the present study the effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin, leptin, and resistin in a set of four chair-restraint habituated intact adult male rhesus monkeys under; 1) normal fed conditions, 2) 24-h fasting cond…
Report a problemFND-2044624005

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Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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