High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736).

Ilic S, Drmic D, Zarkovic K, Kolenc D, Coric M, Brcic L, Klicek R, Radic B, Sever M, Djuzel V, Ivica M, Boban Blagaic A and 7 more

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Zoricic Z, Anic T, Zoricic I, Djidic S, Romic Z, Seiwerth S, Sikiric P

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Apr 2010Cited by 54 (Europe PMC)

PMID20436226PepBankPUB-20436226

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats given extreme paracetamol overdose, prophylactic BPC‑157 prevented convulsions.
In plain wordsIn rats given a paracetamol overdose, BPC‑157 given right away prevented convulsions.
Peptide
BPC-157
Outcome
DecreaseGeneralized convulsions (prophylactic BPC 157)
Study
ratn: not reported in source
Paracetamol overdose (5 g/kg intraperitoneally)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 µg, 10 ng, 10 pg/kg · intraperitoneal or intragastricAs given in this study (rat).
Source sentences
Summary
no convulsions (prophylactic application)
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 therapy (10 microg, 10 ng, 10 pg/kg, intraperitoneally or intragastrically) was effective (microg-ng range) against paracetamol toxicity, given in early (BPC 157 immediately after paracetamol, prophylactically) or advanced stage (BPC 157 at 3 hours after paracetamol, therapeutically).
Report a problemFND-2043622601
02AnimalAnimal study (in vivo)Efficacy outcome
In rats given extreme paracetamol overdose, therapeutic BPC‑157 made convulsions disappear rapidly, within 25 minutes.
In plain wordsIn rats given a paracetamol overdose, BPC‑157 given later stopped convulsions quickly, within 25 minutes.
Peptide
BPC-157
Outcome
DecreaseGeneralized convulsions (therapeutic BPC 157)
Study
ratn: not reported in source
Paracetamol overdose (5 g/kg intraperitoneally)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 µg, 10 ng, 10 pg/kg · intraperitoneal or intragastricAs given in this study (rat).
Measurements
Time to convulsion disappearance
≤ 25 min
therapeutic BPC 157
Source sentences
Summary
convulsions rapidly disappeared (therapeutic effect within 25 min)
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 therapy (10 microg, 10 ng, 10 pg/kg, intraperitoneally or intragastrically) was effective (microg-ng range) against paracetamol toxicity, given in early (BPC 157 immediately after paracetamol, prophylactically) or advanced stage (BPC 157 at 3 hours after paracetamol, therapeutically).
Report a problemFND-2043622602
03AnimalAnimal study (in vivo)Efficacy outcome
In rats given extreme paracetamol overdose, BPC‑157 gave markedly less liver lesions on microscopy.
In plain wordsIn rats given a paracetamol overdose, BPC‑157 led to much less liver damage under the microscope.
Peptide
BPC-157
Outcome
DecreaseLiver lesions (microscopical)
Study
ratn: not reported in source
Paracetamol overdose (5 g/kg intraperitoneally)
Outcome group
Liver fat and liver function · Liver
Studied dose
10 µg, 10 ng, 10 pg/kg · intraperitoneal or intragastricAs given in this study (rat).
Source sentences
Summary
microscopical (markedly less liver and brain lesions
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 therapy (10 microg, 10 ng, 10 pg/kg, intraperitoneally or intragastrically) was effective (microg-ng range) against paracetamol toxicity, given in early (BPC 157 immediately after paracetamol, prophylactically) or advanced stage (BPC 157 at 3 hours after paracetamol, therapeutically).
Report a problemFND-2043622603
04AnimalAnimal study (in vivo)Efficacy outcome
In rats given extreme paracetamol overdose, BPC‑157 gave markedly less brain lesions on microscopy.
In plain wordsIn rats given a paracetamol overdose, BPC‑157 led to much less brain damage under the microscope.
Peptide
BPC-157
Outcome
DecreaseBrain lesions (microscopical)
Study
ratn: not reported in source
Paracetamol overdose (5 g/kg intraperitoneally)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 µg, 10 ng, 10 pg/kg · intraperitoneal or intragastricAs given in this study (rat).
Source sentences
Summary
microscopical (markedly less liver and brain lesions
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 therapy (10 microg, 10 ng, 10 pg/kg, intraperitoneally or intragastrically) was effective (microg-ng range) against paracetamol toxicity, given in early (BPC 157 immediately after paracetamol, prophylactically) or advanced stage (BPC 157 at 3 hours after paracetamol, therapeutically).
Report a problemFND-2043622604
05AnimalAnimal study (in vivo)Efficacy outcome
In rats given extreme paracetamol overdose, BPC‑157 decreased serum levels of liver enzymes.
In plain wordsIn rats given a paracetamol overdose, BPC‑157 lowered blood levels of liver enzymes.
Peptide
BPC-157
Outcome
DecreaseLiver enzyme serum levels (ALT, AST)
Study
ratn: not reported in source
Paracetamol overdose (5 g/kg intraperitoneally)
Outcome group
Liver fat and liver function · Liver
Studied dose
10 µg, 10 ng, 10 pg/kg · intraperitoneal or intragastricAs given in this study (rat).
Source sentences
Summary
biochemical (enzyme and ammonium serum levels decreased
2 context sentences(design, population, supporting numbers)
Summary · context
increased ALT, AST and ammonium serum values precede liver lesion while in several brain areas, significant damage became apparent, accompanied by generalized convulsions.
Summary · context
BPC 157 therapy (10 microg, 10 ng, 10 pg/kg, intraperitoneally or intragastrically) was effective (microg-ng range) against paracetamol toxicity, given in early (BPC 157 immediately after paracetamol, prophylactically) or advanced stage (BPC 157 at 3 hours after paracetamol, therapeutically).
Report a problemFND-2043622605
06AnimalAnimal study (in vivo)Efficacy outcome
In rats given extreme paracetamol overdose, BPC‑157 decreased serum ammonium levels.
In plain wordsIn rats given a paracetamol overdose, BPC‑157 lowered blood ammonium levels.
Peptide
BPC-157
Outcome
DecreaseAmmonium serum level
Study
ratn: not reported in source
Paracetamol overdose (5 g/kg intraperitoneally)
Outcome group
Liver fat and liver function · Liver
Studied dose
10 µg, 10 ng, 10 pg/kg · intraperitoneal or intragastricAs given in this study (rat).
Source sentences
Summary
biochemical (enzyme and ammonium serum levels decreased
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 therapy (10 microg, 10 ng, 10 pg/kg, intraperitoneally or intragastrically) was effective (microg-ng range) against paracetamol toxicity, given in early (BPC 157 immediately after paracetamol, prophylactically) or advanced stage (BPC 157 at 3 hours after paracetamol, therapeutically).
Report a problemFND-2043622606

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

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