Endocrine, ovulatory and reproductive characteristics of sows treated with an intravaginal GnRH agonist.

Stewart KR, Flowers WL, Rampacek GB, Greger DL, Swanson ME, Hafs HD

Animal reproduction science14 Apr 2010Cited by 22 (Europe PMC)

PMID20430539DOI10.1016/j.anireprosci.2010.04.003PepBankPUB-20430539

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In weaned sows, triptorelin produced LH surge magnitudes comparable to spontaneous surges in gel-only controls.
In plain wordsIn sows, triptorelin produced LH surges of similar size to spontaneous surges in gel-only controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changePreovulatory LH surge magnitude
Study
pign: not reported in source
Weaned sows
Comparator
Methylcellulose gel alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 microg · intravaginal · Single administrationAs given in this study (pig).
Source sentences
Summary
Sows treated intravaginally with triptorelin exhibited preovulatory LH surges with magnitudes comparable to those that occurred spontaneously in the negative controls.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study examined the effectiveness of intravaginal administration of a GnRH agonist, triptorelin, on the induction of the preovulatory LH surge; synchronization of time of ovulation; and reproductive characteristics in weaned sows.
Summary · context
Sows were given 100microg of triptorelin in 0.9, 1.2, or 1.5% methylcellulose gel intravaginally 96h after weaning and then bred at 8 and 32h post-treatment.
Summary · context
Untreated sows inseminated once each day of estrus served as the positive controls, while females treated with only the methyl cellulose gel and also bred once each day of estrus were negative controls.
Report a problemFND-2043053901
02AnimalAnimal study (in vivo)Efficacy outcome
In weaned sows, triptorelin in higher-concentration methylcellulose gel initiated LH surges within 4-12h after treatment.
In plain wordsIn sows, triptorelin in higher-concentration gel initiated LH surges within 4-12h after treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableLH surge timing with higher gel concentrations
Study
pign: not reported in source
Weaned sows
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 microg · intravaginal · Single administrationAs given in this study (pig).
Measurements
LH surge onset
4 to 12 h
1.2 or 1.5% methylcellulose gel
Source sentences
Summary
Preovulatory LH surges were initiated over a narrow and well-defined time interval that occurred 4-12h after treatment in sows receiving triptorelin in 1.2 or 1.5% methyl cellulose gel.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study examined the effectiveness of intravaginal administration of a GnRH agonist, triptorelin, on the induction of the preovulatory LH surge; synchronization of time of ovulation; and reproductive characteristics in weaned sows.
Summary · context
Sows were given 100microg of triptorelin in 0.9, 1.2, or 1.5% methylcellulose gel intravaginally 96h after weaning and then bred at 8 and 32h post-treatment.
Summary · context
Untreated sows inseminated once each day of estrus served as the positive controls, while females treated with only the methyl cellulose gel and also bred once each day of estrus were negative controls.
Report a problemFND-2043053902
03AnimalAnimal study (in vivo)Efficacy outcome
In weaned sows, most animals given triptorelin in higher-concentration gel ovulated within 36-48h after treatment.
In plain wordsIn sows, most animals given triptorelin in higher-concentration gel ovulated within 36-48h after treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableOvulation timing with higher gel concentrations
Study
pign: not reported in source
Weaned sows
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 microg · intravaginal · Single administrationAs given in this study (pig).
Measurements
Ovulation timing
36 to 48 h
1.2 or 1.5% methylcellulose gel
Source sentences
Summary
As a result, the majority of the sows in these two treatments had ovulations within a 12h time frame 36-48h after treatment.
4 context sentences(design, population, supporting numbers)
Summary · context
Preovulatory LH surges were initiated over a narrow and well-defined time interval that occurred 4-12h after treatment in sows receiving triptorelin in 1.2 or 1.5% methyl cellulose gel.
Summary · context
The present study examined the effectiveness of intravaginal administration of a GnRH agonist, triptorelin, on the induction of the preovulatory LH surge; synchronization of time of ovulation; and reproductive characteristics in weaned sows.
Summary · context
Sows were given 100microg of triptorelin in 0.9, 1.2, or 1.5% methylcellulose gel intravaginally 96h after weaning and then bred at 8 and 32h post-treatment.
Summary · context
Untreated sows inseminated once each day of estrus served as the positive controls, while females treated with only the methyl cellulose gel and also bred once each day of estrus were negative controls.
Report a problemFND-2043053903

Studies that did not test the peptide alone4

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

04AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In weaned sows, LH surges occurred over extended periods after weaning with triptorelin in low-concentration gel, as in negative controls.
In plain wordsIn sows, LH surges occurred over extended periods with triptorelin in low-concentration gel, as in gel-only controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeLH surge timing with low gel concentration
Study
pign: not reported in source
Weaned sows
Comparator
Methylcellulose gel alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
In contrast, both the LH surge and ovulation occurred over extended periods of time after weaning in negative controls and sows given triptorelin in 0.9% methylcellulose gel.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study examined the effectiveness of intravaginal administration of a GnRH agonist, triptorelin, on the induction of the preovulatory LH surge; synchronization of time of ovulation; and reproductive characteristics in weaned sows.
Summary · context
Sows were given 100microg of triptorelin in 0.9, 1.2, or 1.5% methylcellulose gel intravaginally 96h after weaning and then bred at 8 and 32h post-treatment.
Summary · context
Untreated sows inseminated once each day of estrus served as the positive controls, while females treated with only the methyl cellulose gel and also bred once each day of estrus were negative controls.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2043053904
05AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In weaned sows, ovulation occurred over extended periods after weaning with triptorelin in low-concentration gel, as in negative controls.
In plain wordsIn sows, ovulation occurred over extended periods with triptorelin in low-concentration gel, as in gel-only controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeOvulation timing with low gel concentration
Study
pign: not reported in source
Weaned sows
Comparator
Methylcellulose gel alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
In contrast, both the LH surge and ovulation occurred over extended periods of time after weaning in negative controls and sows given triptorelin in 0.9% methylcellulose gel.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study examined the effectiveness of intravaginal administration of a GnRH agonist, triptorelin, on the induction of the preovulatory LH surge; synchronization of time of ovulation; and reproductive characteristics in weaned sows.
Summary · context
Sows were given 100microg of triptorelin in 0.9, 1.2, or 1.5% methylcellulose gel intravaginally 96h after weaning and then bred at 8 and 32h post-treatment.
Summary · context
Untreated sows inseminated once each day of estrus served as the positive controls, while females treated with only the methyl cellulose gel and also bred once each day of estrus were negative controls.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2043053905
06AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In weaned sows, farrowing rates were similar between triptorelin-treated animals with fixed-time inseminations and untreated controls.
In plain wordsIn sows, birth rates were similar between triptorelin-treated animals with fixed-time inseminations and untreated controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeFarrowing rate
Study
pign: not reported in source
Weaned sows
Comparator
Untreated controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Farrowing rates and litter size were similar between untreated controls and triptorelin-treated sows that were bred with two fixed timed inseminations.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study examined the effectiveness of intravaginal administration of a GnRH agonist, triptorelin, on the induction of the preovulatory LH surge; synchronization of time of ovulation; and reproductive characteristics in weaned sows.
Summary · context
Sows were given 100microg of triptorelin in 0.9, 1.2, or 1.5% methylcellulose gel intravaginally 96h after weaning and then bred at 8 and 32h post-treatment.
Summary · context
Untreated sows inseminated once each day of estrus served as the positive controls, while females treated with only the methyl cellulose gel and also bred once each day of estrus were negative controls.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2043053906
07AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In weaned sows, litter size was similar between triptorelin-treated animals with fixed-time inseminations and untreated controls.
In plain wordsIn sows, litter size was similar between triptorelin-treated animals with fixed-time inseminations and untreated controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeLitter size
Study
pign: not reported in source
Weaned sows
Comparator
Untreated controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Farrowing rates and litter size were similar between untreated controls and triptorelin-treated sows that were bred with two fixed timed inseminations.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study examined the effectiveness of intravaginal administration of a GnRH agonist, triptorelin, on the induction of the preovulatory LH surge; synchronization of time of ovulation; and reproductive characteristics in weaned sows.
Summary · context
Sows were given 100microg of triptorelin in 0.9, 1.2, or 1.5% methylcellulose gel intravaginally 96h after weaning and then bred at 8 and 32h post-treatment.
Summary · context
Untreated sows inseminated once each day of estrus served as the positive controls, while females treated with only the methyl cellulose gel and also bred once each day of estrus were negative controls.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2043053907

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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