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Study · Not a test of the peptide alone · 2010

3 results

[Effect of [Gly14]-Humanin on Abeta(25-35)-induced PC12 cell apoptosis].

Jin H, Hu HT, Wang WX, Feng GF, Li YY, Yang WN

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology1 May 2010

PMID20423647 (opens in a new tab)PepBankPUB-20423647
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    After Abeta(25-35) exposure, PC12 cells overexpressing the HNG gene had significantly higher cell viability than empty plasmid transfected cells.

    In plain wordsIn cells, switching on a humanin-derivative gene kept more nerve-like cells alive after amyloid beta exposure than in control cells.

    Peptide
    Humanin
    Outcome
    IncreaseCell viability after Abeta(25-35)
    Study

    n: not reported in source

    PC12 cells stably expressing HNG, exposed to Abeta(25-35)
    Comparator
    Empty plasmid transfected cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    After being treated with 25 micromol/L Abeta(25-35); for 24 h, cell viability of PC12 cells overexpression HNG was significant elevated compared with empty plasmid transfected cells (P<0.05), and the apoptosis rate was lower significantly (P<0.05).
    1 context sentence
    Summary · context
    Recombinant plasmid pcDNA3.1(-)/HNG-FLAG was transfected into PC12 cells by liposome method.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    After Abeta(25-35) exposure, PC12 cells overexpressing the HNG gene had a significantly lower apoptosis rate than empty plasmid transfected cells.

    In plain wordsIn cells, switching on a humanin-derivative gene lowered cell death after amyloid beta exposure compared with control cells.

    Peptide
    Humanin
    Outcome
    DecreaseApoptosis rate after Abeta(25-35)
    Study

    n: not reported in source

    PC12 cells stably expressing HNG, exposed to Abeta(25-35)
    Comparator
    Empty plasmid transfected cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    After being treated with 25 micromol/L Abeta(25-35); for 24 h, cell viability of PC12 cells overexpression HNG was significant elevated compared with empty plasmid transfected cells (P<0.05), and the apoptosis rate was lower significantly (P<0.05).
    1 context sentence
    Summary · context
    Recombinant plasmid pcDNA3.1(-)/HNG-FLAG was transfected into PC12 cells by liposome method.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    By Hoechst staining, the nuclei of PC12 cells overexpressing HNG were round and homogeneously stained, unlike the condensed and fragmented nuclei of empty plasmid cells.

    In plain wordsIn cells, the nuclei of cells with the humanin-derivative gene looked healthy, while control cells showed signs of cell death.

    Peptide
    Humanin
    Outcome
    Not applicableNuclear morphology (Hoechst 33258 staining)
    Study

    n: not reported in source

    PC12 cells stably expressing HNG, exposed to Abeta(25-35)
    Comparator
    Empty plasmid transfected cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    By Hoechst 33258 staining, the nuclei of empty plasmid transfected PC12 cells exhibited highly condensed and fragmented nuclei morphology which was the typical characteristics of apoptosis, and the nuclei of PC12 cells overexpression HNG were round and homogeneously stained.
    1 context sentence
    Summary · context
    Recombinant plasmid pcDNA3.1(-)/HNG-FLAG was transfected into PC12 cells by liposome method.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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