Effect of glutathione on the cadmium chelation of EDTA in a patient with cadmium intoxication.

Gil HW, Kang EJ, Lee KH, Yang JO, Lee EY, Hong SY, Hong SY

Human & experimental toxicology22 Apr 2010Cited by 25 (Europe PMC)

PMID20413561DOI10.1177/0960327110369818PepBankPUB-20413561

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Glutathione.

01HumanNot a test of Glutathione aloneCase report or seriesEfficacy outcome
In a patient with cadmium intoxication, EDTA with glutathione increased blood cadmium compared with saline baseline.
In plain wordsIn a patient with cadmium intoxication, EDTA with glutathione increased blood cadmium compared with saline baseline.
Peptide
Glutathione
Outcome
IncreaseBlood cadmium
Study
n = 1
Comparator
Saline baseline
Outcome group
Pharmacokinetics · Whole body
Measurements
Blood cadmium
7.44 µg/L
EDTA with glutathione
Blood cadmium
4.6 µg/L
baseline
Blood and urine samples to analyze per group
6 samples
Each protocol group
Reported ± uncertainty for blood cadmium (type unspecified)
0.73 µg/L
EDTA with glutathione, parent value 7.44 µg/L
Reported ± uncertainty for blood cadmium (type unspecified)
0.44 µg/L
Saline baseline, parent value 4.6 µg/L
P value
< 0.01
Blood cadmium, EDTA with glutathione versus basal level
Source sentences
Summary
The blood cadmium level was higher when the EDTA was infused together with glutathione (7.44 ± 0.73 µg/L, p < 0.01) compared to the basal level of 4.6 ± 0.44 µg/L.
3 context sentences(design, population, supporting numbers)
Summary · context
in a 54-year-old patient with chronic cadmium intoxication.
Summary · context
During the first 3 days, the basal levels (only saline administration) were determined; during the second 3 days, Ca(++)-EDTA only was administered, for the third sequence of 3 days, Ca(++)-EDTA with glutathione was provided, and for the last 3 days, glutathione alone was given.
Summary · context
There were six blood and urine samples to analyze in each group.
In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glutathione.
Report a problemFND-2041356101
02HumanNot a test of Glutathione aloneCase report or seriesEfficacy outcome
In a patient with cadmium intoxication, EDTA with glutathione increased renal cadmium excretion compared with saline baseline.
In plain wordsIn a patient with cadmium intoxication, EDTA with glutathione increased cadmium excretion in urine compared with saline baseline.
Peptide
Glutathione
Outcome
IncreaseRenal cadmium excretion
Study
n = 1
Comparator
Saline baseline
Outcome group
Pharmacokinetics · Kidney and urinary
Measurements
Blood and urine samples to analyze per group
6 samples
Each protocol group
Renal cadmium excretion
23.4 µg/g creatinine
EDTA with glutathione versus basal group, first source-listed value, arm assignment unclear
Reported ± uncertainty for renal cadmium excretion (type unspecified)
15.81 µg/g creatinine
First source-listed value, parent value 23.4 µg/g creatinine, arm assignment unclear
Renal cadmium excretion
89.23 µg/g creatinine
EDTA with glutathione versus basal group, second source-listed value, arm assignment unclear
Reported ± uncertainty for renal cadmium excretion (type unspecified)
58.52 µg/g creatinine
Second source-listed value, parent value 89.23 µg/g creatinine, arm assignment unclear
P value
< 0.01
Renal cadmium excretion, EDTA with glutathione versus basal group
Source sentences
Summary
Also, the renal cadmium excretion was significantly higher in the EDTA with glutathione group than in the basal group (23.4 ± 15.81 µg/g creatinine vs 89.23 ± 58.52 µg/g creatinine, p < 0.01).
3 context sentences(design, population, supporting numbers)
Summary · context
in a 54-year-old patient with chronic cadmium intoxication.
Summary · context
During the first 3 days, the basal levels (only saline administration) were determined; during the second 3 days, Ca(++)-EDTA only was administered, for the third sequence of 3 days, Ca(++)-EDTA with glutathione was provided, and for the last 3 days, glutathione alone was given.
Summary · context
There were six blood and urine samples to analyze in each group.
In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glutathione.
Report a problemFND-2041356102
03HumanNot a test of Glutathione aloneCase report or seriesSafety outcome
In a patient with cadmium intoxication, urinary protein/creatinine ratio did not differ among the glutathione-containing and other protocol groups.
In plain wordsIn a patient with cadmium intoxication, urine protein/creatinine ratio did not differ among glutathione-containing and other protocol groups.
Peptide
Glutathione
Outcome
No significant changeUrinary protein/creatinine ratio
Study
n = 1
Comparator
Other protocol groups
Outcome group
Kidney function · Kidney and urinary
Measurements
Blood and urine samples to analyze per group
6 samples
Each protocol group
P value
> 0.05
Urinary protein/creatinine ratio, among protocol groups
Source sentences
Summary
There was no difference in the protein/creatinine and β(2)-microglobulin/creatinine ratio in the urine (p > 0.05) among the groups.
3 context sentences(design, population, supporting numbers)
Summary · context
in a 54-year-old patient with chronic cadmium intoxication.
Summary · context
During the first 3 days, the basal levels (only saline administration) were determined; during the second 3 days, Ca(++)-EDTA only was administered, for the third sequence of 3 days, Ca(++)-EDTA with glutathione was provided, and for the last 3 days, glutathione alone was given.
Summary · context
There were six blood and urine samples to analyze in each group.
In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glutathione.
Report a problemFND-2041356103
04HumanNot a test of Glutathione aloneCase report or seriesSafety outcome
In a patient with cadmium intoxication, urinary β(2)-microglobulin/creatinine ratio did not differ among the glutathione-containing and other protocol groups.
In plain wordsIn a patient with cadmium intoxication, urine β(2)-microglobulin/creatinine ratio did not differ among glutathione-containing and other protocol groups.
Peptide
Glutathione
Outcome
No significant changeUrinary beta2-microglobulin/creatinine ratio
Study
n = 1
Comparator
Other protocol groups
Outcome group
Kidney function · Kidney and urinary
Measurements
Blood and urine samples to analyze per group
6 samples
Each protocol group
P value
> 0.05
Urinary beta2-microglobulin/creatinine ratio, among protocol groups
Source sentences
Summary
There was no difference in the protein/creatinine and β(2)-microglobulin/creatinine ratio in the urine (p > 0.05) among the groups.
3 context sentences(design, population, supporting numbers)
Summary · context
in a 54-year-old patient with chronic cadmium intoxication.
Summary · context
During the first 3 days, the basal levels (only saline administration) were determined; during the second 3 days, Ca(++)-EDTA only was administered, for the third sequence of 3 days, Ca(++)-EDTA with glutathione was provided, and for the last 3 days, glutathione alone was given.
Summary · context
There were six blood and urine samples to analyze in each group.
In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glutathione.
Report a problemFND-2041356104
05HumanNot a test of Glutathione aloneCase report or seriesSafety outcome
In a patient with cadmium intoxication treated with a protocol including glutathione and EDTA, microhematuria did not develop during observation.
In plain wordsIn a patient with cadmium intoxication, microhematuria did not develop during observation after a protocol including glutathione and EDTA.
Peptide
Glutathione
Outcome
Not applicableMicrohematuria
Study
n = 1
Outcome group
Adverse events · Kidney and urinary
Source sentences
Summary
Furthermore, microhematuria and proteinuria did not develop over the observation period of 6 months.
2 context sentences(design, population, supporting numbers)
Summary · context
in a 54-year-old patient with chronic cadmium intoxication.
Summary · context
During the first 3 days, the basal levels (only saline administration) were determined; during the second 3 days, Ca(++)-EDTA only was administered, for the third sequence of 3 days, Ca(++)-EDTA with glutathione was provided, and for the last 3 days, glutathione alone was given.
In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glutathione.
Report a problemFND-2041356105
06HumanNot a test of Glutathione aloneCase report or seriesSafety outcome
In a patient with cadmium intoxication treated with a protocol including glutathione and EDTA, proteinuria did not develop during observation.
In plain wordsIn a patient with cadmium intoxication, proteinuria did not develop during observation after a protocol including glutathione and EDTA.
Peptide
Glutathione
Outcome
Not applicableProteinuria
Study
n = 1
Outcome group
Adverse events · Kidney and urinary
Source sentences
Summary
Furthermore, microhematuria and proteinuria did not develop over the observation period of 6 months.
2 context sentences(design, population, supporting numbers)
Summary · context
in a 54-year-old patient with chronic cadmium intoxication.
Summary · context
During the first 3 days, the basal levels (only saline administration) were determined; during the second 3 days, Ca(++)-EDTA only was administered, for the third sequence of 3 days, Ca(++)-EDTA with glutathione was provided, and for the last 3 days, glutathione alone was given.
In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glutathione.
Report a problemFND-2041356106

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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