Kisspeptin regulates prolactin release through hypothalamic dopaminergic neurons.

Szawka RE, Ribeiro AB, Leite CM, Helena CV, Franci CR, Anderson GM, Hoffman GE, Anselmo-Franci JA

Endocrinology21 Apr 2010Cited by 78 (Europe PMC)

PMID20410200DOI10.1210/en.2009-1414PepBankPUB-20410200

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In estradiol-treated ovariectomized adult rats, central kisspeptin‑10 increased prolactin release in a dose-dependent manner.
In plain wordsIn rats, kisspeptin‑10 given into the brain raised prolactin release, and a higher dose gave a larger rise.
Peptide
Kisspeptin-10
Outcome
IncreaseProlactin release in estradiol-treated ovariectomized rats
Study
ratn: not reported in source
ovariectomized rats treated with estradiol (OVX+E2)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Intracerebroventricular kisspeptin-10 (Kp-10) elicited PRL release in a dose-dependent manner in estradiol (E2)-treated ovariectomized rats (OVX+E2), whereas no effect was found in oil-treated ovariectomized rats (OVX).
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the role of kisspeptin in the control of hypothalamic DA and pituitary PRL secretion in adult rats.
Report a problemFND-2041020001
02AnimalAnimal study (in vivo)Activity measurement
In oil-treated ovariectomized adult rats, central kisspeptin‑10 did not change prolactin release.
In plain wordsIn rats without estradiol treatment, kisspeptin‑10 given into the brain did not change prolactin release.
Peptide
Kisspeptin-10
Outcome
No significant changeProlactin release in oil-treated ovariectomized rats
Study
ratn: not reported in source
ovariectomized rats treated with oil (OVX)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Intracerebroventricular kisspeptin-10 (Kp-10) elicited PRL release in a dose-dependent manner in estradiol (E2)-treated ovariectomized rats (OVX+E2), whereas no effect was found in oil-treated ovariectomized rats (OVX).
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the role of kisspeptin in the control of hypothalamic DA and pituitary PRL secretion in adult rats.
Report a problemFND-2041020002
03AnimalAnimal study (in vivo)Activity measurement
Kisspeptin‑10 increased prolactin release in male and proestrous female adult rats.
In plain wordsIn rats, kisspeptin‑10 raised prolactin release in males and in females in the proestrous stage.
Peptide
Kisspeptin-10
Outcome
IncreaseProlactin release in males and proestrous females
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Kp-10 increased PRL release in males and proestrous
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the role of kisspeptin in the control of hypothalamic DA and pituitary PRL secretion in adult rats.
Report a problemFND-2041020003
04AnimalAnimal study (in vivo)Activity measurement
Kisspeptin‑10 did not change prolactin release in diestrous female adult rats.
In plain wordsIn rats, kisspeptin‑10 did not change prolactin release in females in the diestrous stage.
Peptide
Kisspeptin-10
Outcome
No significant changeProlactin release in diestrous females
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Kp-10 increased PRL release in males and proestrous but not diestrous females.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the role of kisspeptin in the control of hypothalamic DA and pituitary PRL secretion in adult rats.
Report a problemFND-2041020004
05AnimalAnimal study (in vivo)Mechanism
In estradiol-treated ovariectomized rats, central kisspeptin‑10 reduced Fos-related antigen expression in tyrosine hydroxylase neurons of the arcuate and periventricular nuclei.
In plain wordsIn rats, kisspeptin‑10 given into the brain lowered a marker of activity in dopamine-producing brain cells.
Peptide
Kisspeptin-10
Outcome
DecreaseFos-related antigen in tyrosine hydroxylase neurons, OVX+E2 rats
Study
ratn: not reported in source
ovariectomized rats treated with estradiol (OVX+E2)
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Associated with the increase in PRL release, intracerebroventricular Kp-10 reduced Fos-related antigen expression in tyrosine hydroxylase-immunoreactive (ir) neurons of arcuate and periventricular nuclei in OVX+E2 rats, with no effect in OVX rats.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the role of kisspeptin in the control of hypothalamic DA and pituitary PRL secretion in adult rats.
Report a problemFND-2041020005
06AnimalAnimal study (in vivo)Mechanism
In oil-treated ovariectomized rats, central kisspeptin‑10 did not change Fos-related antigen expression in tyrosine hydroxylase neurons.
In plain wordsIn rats without estradiol treatment, kisspeptin‑10 given into the brain did not change this marker of activity in dopamine-producing brain cells.
Peptide
Kisspeptin-10
Outcome
No significant changeFos-related antigen in tyrosine hydroxylase neurons, OVX rats
Study
ratn: not reported in source
ovariectomized rats treated with oil (OVX)
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Associated with the increase in PRL release, intracerebroventricular Kp-10 reduced Fos-related antigen expression in tyrosine hydroxylase-immunoreactive (ir) neurons of arcuate and periventricular nuclei in OVX+E2 rats, with no effect in OVX rats.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the role of kisspeptin in the control of hypothalamic DA and pituitary PRL secretion in adult rats.
Report a problemFND-2041020006
07AnimalAnimal study (in vivo)Mechanism
In estradiol-treated ovariectomized rats, kisspeptin‑10 decreased 3,4-dihydroxyphenylacetic acid concentration in the median eminence.
In plain wordsIn rats, kisspeptin‑10 lowered a dopamine breakdown product in the median eminence of the brain.
Peptide
Kisspeptin-10
Outcome
DecreaseDOPAC concentration in median eminence
Study
ratn: not reported in source
ovariectomized rats treated with estradiol (OVX+E2)
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Kp-10 also decreased 3,4-dihydroxyphenylacetic acid concentration and 3,4-dihydroxyphenylacetic acid-DA ratio in the median eminence
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the role of kisspeptin in the control of hypothalamic DA and pituitary PRL secretion in adult rats.
Report a problemFND-2041020007
08AnimalAnimal study (in vivo)Mechanism
In estradiol-treated ovariectomized rats, kisspeptin‑10 decreased the 3,4-dihydroxyphenylacetic acid-DA ratio in the median eminence.
In plain wordsIn rats, kisspeptin‑10 lowered the ratio of a dopamine breakdown product to dopamine in the median eminence of the brain.
Peptide
Kisspeptin-10
Outcome
DecreaseDOPAC-DA ratio in median eminence
Study
ratn: not reported in source
ovariectomized rats treated with estradiol (OVX+E2)
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Kp-10 also decreased 3,4-dihydroxyphenylacetic acid concentration and 3,4-dihydroxyphenylacetic acid-DA ratio in the median eminence but not striatum in OVX+E2 rats.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the role of kisspeptin in the control of hypothalamic DA and pituitary PRL secretion in adult rats.
Report a problemFND-2041020008
09AnimalAnimal study (in vivo)Mechanism
In estradiol-treated ovariectomized rats, kisspeptin‑10 did not change 3,4-dihydroxyphenylacetic acid concentration or its ratio to DA in the striatum.
In plain wordsIn rats, kisspeptin‑10 did not change dopamine breakdown measures in the striatum of the brain.
Peptide
Kisspeptin-10
Outcome
No significant changeDOPAC concentration and DOPAC-DA ratio in striatum
Study
ratn: not reported in source
ovariectomized rats treated with estradiol (OVX+E2)
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Kp-10 also decreased 3,4-dihydroxyphenylacetic acid concentration and 3,4-dihydroxyphenylacetic acid-DA ratio in the median eminence but not striatum in OVX+E2 rats.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the role of kisspeptin in the control of hypothalamic DA and pituitary PRL secretion in adult rats.
Report a problemFND-2041020009
10LabIn vitro (cells)Activity measurement
In anterior pituitary cell cultures, kisspeptin‑10 did not change prolactin release, with or without estradiol treatment.
In plain wordsIn cells from the rat pituitary gland, kisspeptin‑10 did not change prolactin release, with or without estradiol.
Peptide
Kisspeptin-10
Outcome
No significant changeProlactin release from anterior pituitary cell cultures
Study
ratn: not reported in source
anterior pituitary cell cultures
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
In addition, Kp-10 was not found to alter PRL release from anterior pituitary cell cultures regardless of E2 treatment.
Report a problemFND-2041020010

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

11AnimalEndogenous levelAnimal study (in vivo)Mechanism
In adult rats, the body's own kisspeptin-immunoreactive fibres were in close apposition to and in contact with tyrosine hydroxylase-immunoreactive perikarya in the arcuate nucleus.
In plain wordsIn rats, the body's own kisspeptin fibres touched dopamine-producing brain cells in a key brain area.
Peptide
Kisspeptin-10
Outcome
Not applicableKisspeptin fibres in contact with tyrosine hydroxylase neurons in the arcuate nucleus
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Double-label immunofluorescence combined with confocal microscopy revealed kisspeptin-ir fibers in close apposition to and in contact with tyrosine hydroxylase-ir perikarya in the arcuate.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2041020011

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.