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Study · Animal study (in vivo) · rat · 2010

6 results

Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects.

Castellano JM, Bentsen AH, Romero M, Pineda R, Ruiz-Pino F, Garcia-Galiano D, Sánchez-Garrido MA, Pinilla L, Mikkelsen JD, Tena-Sempere M

American journal of physiology. Endocrinology and metabolism20 Apr 2010Cited by 49 (Europe PMC)

PMID20407007 (opens in a new tab)DOI10.1152/ajpendo.00081.2010 (opens in a new tab)PepBankPUB-20407007
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In LPS-treated male rats, the absolute LH response to kisspeptin‑10 was significantly attenuated.

    In plain wordsIn rats with inflammation, kisspeptin‑10 caused a smaller rise in LH.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseLH response to kisspeptin-10 in LPS-treated males
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, absolute responses to kisspeptin-10 (Kp-10), in terms of LH and testosterone secretion, were significantly attenuated in LPS-treated males that also displayed a decrease in food intake and body weight.
    1 context sentence
    Summary · context
    Using lipopolysaccharide S (LPS)-treated male rats as model of inflammation, we document herein the pattern of hypothalamic kisspeptin immunoreactivity (IR) and hormonal responses to kisspeptin during the acute inflammatory phase.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In LPS-treated male rats, the absolute testosterone response to kisspeptin‑10 was significantly attenuated.

    In plain wordsIn rats with inflammation, kisspeptin‑10 caused a smaller rise in testosterone.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseTestosterone response to kisspeptin-10 in LPS-treated males
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, absolute responses to kisspeptin-10 (Kp-10), in terms of LH and testosterone secretion, were significantly attenuated in LPS-treated males that also displayed a decrease in food intake and body weight.
    1 context sentence
    Summary · context
    Using lipopolysaccharide S (LPS)-treated male rats as model of inflammation, we document herein the pattern of hypothalamic kisspeptin immunoreactivity (IR) and hormonal responses to kisspeptin during the acute inflammatory phase.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In pair-fed male rats, the LH response to Kp-10 did not show the alteration seen with LPS; its magnitude was preserved, if not augmented.

    In plain wordsIn rats given less food, the LH response to kisspeptin‑10 stayed intact, unlike in rats with inflammation.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLH response to kisspeptin-10 in pair-fed males
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Yet pair-fed males did not show similar alterations in LH and testosterone secretory responses to Kp-10, whose magnitude was preserved, if not augmented, during food restriction.
    1 context sentence
    Summary · context
    Using lipopolysaccharide S (LPS)-treated male rats as model of inflammation, we document herein the pattern of hypothalamic kisspeptin immunoreactivity (IR) and hormonal responses to kisspeptin during the acute inflammatory phase.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In pair-fed male rats, the testosterone response to Kp-10 did not show the alteration seen with LPS; its magnitude was preserved, if not augmented.

    In plain wordsIn rats given less food, the testosterone response to kisspeptin‑10 stayed intact, unlike in rats with inflammation.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeTestosterone response to kisspeptin-10 in pair-fed males
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Yet pair-fed males did not show similar alterations in LH and testosterone secretory responses to Kp-10, whose magnitude was preserved, if not augmented, during food restriction.
    1 context sentence
    Summary · context
    Using lipopolysaccharide S (LPS)-treated male rats as model of inflammation, we document herein the pattern of hypothalamic kisspeptin immunoreactivity (IR) and hormonal responses to kisspeptin during the acute inflammatory phase.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 05AnimalEndogenous levelAnimal study (in vivo)Other

    In male rats given lipopolysaccharide, the body's own kisspeptin immunoreactivity in the arcuate nucleus decreased significantly.

    In plain wordsIn rats with inflammation, the body's own kisspeptin in a key brain area was lower.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKisspeptin immunoreactivity in the arcuate nucleus after LPS
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Suppression of gonadotropic function was associated with a significant decrease in kisspeptin-IR in the arcuate nucleus (ARC)
    1 context sentence
    Summary · context
    Using lipopolysaccharide S (LPS)-treated male rats as model of inflammation, we document herein the pattern of hypothalamic kisspeptin immunoreactivity (IR) and hormonal responses to kisspeptin during the acute inflammatory phase.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 06AnimalEndogenous levelAnimal study (in vivo)Other

    In male rats fasted for 48 h, the body's own kisspeptin immunoreactivity in the arcuate nucleus did not decrease.

    In plain wordsIn rats that fasted for 48 hours, the body's own kisspeptin in a key brain area did not drop.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeKisspeptin immunoreactivity in the arcuate nucleus after 48-h fasting
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Suppression of gonadotropic function was associated with a significant decrease in kisspeptin-IR in the arcuate nucleus (ARC) that was not observed under conditions of metabolic stress induced by 48-h fasting.
    1 context sentence
    Summary · context
    Using lipopolysaccharide S (LPS)-treated male rats as model of inflammation, we document herein the pattern of hypothalamic kisspeptin immunoreactivity (IR) and hormonal responses to kisspeptin during the acute inflammatory phase.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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