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Study · In vitro (cells) · 2010

5 results

Humanin protects neurons against apoptosis induced by Abeta31-35 through suppression of intrinsic pathway.

Li LM, Zhang Y, Qiao JT, Zhang C

Sheng li xue bao : [Acta physiologica Sinica]1 Apr 2010Cited by 4 (Europe PMC)

PMID20401442 (opens in a new tab)PepBankPUB-20401442
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cortical neurons, pretreatment with humanin at 20 micromol/L for 16 h significantly prevented Abeta31-35-induced apoptosis.

    In plain wordsIn cells, pretreatment with humanin protected nerve cells from death caused by amyloid beta.

    Peptide
    Humanin
    Outcome
    DecreaseAbeta31-35-induced neuronal apoptosis
    Study

    n: not reported in source

    Primary cultured cortical neurons exposed to Abeta31-35
    Comparator
    Abeta31-35 alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    20 micromol/L · 16 h pretreatmentAs given in this study.

    Source sentences

    Summary
    (1) Pretreatment with HN (20 micromol/L) for 16 h significantly prevented Abeta31-35-induced apoptosis in cortical neurons
    1 context sentence
    Summary · context
    Cultured cortical neurons were pretreated with different concentrations of HN (5, 10, 20 micromol/L) for different time period (0, 8 and 16 h) respectively, and then exposed to Abeta31-35 (25 micromol/L) for additional 24 h and the neuronal apoptosis was examined by morphological analysis, flow cyto…
  2. 02LabIn vitro (cells)Mechanism

    In cortical neurons, humanin significantly decreased the Abeta31-35-induced elevation of caspase-3 activity.

    In plain wordsIn cells, humanin lowered the rise in a cell-death enzyme that amyloid beta caused in nerve cells.

    Peptide
    Humanin
    Outcome
    DecreaseCaspase-3 activity
    Study

    n: not reported in source

    Primary cultured cortical neurons exposed to Abeta31-35
    Comparator
    Abeta31-35 alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    (2) HN significantly decreased Abeta31-35-induced elevation of caspase-3 and -9 activities
    1 context sentence
    Summary · context
    Cultured cortical neurons were pretreated with different concentrations of HN (5, 10, 20 micromol/L) for different time period (0, 8 and 16 h) respectively, and then exposed to Abeta31-35 (25 micromol/L) for additional 24 h and the neuronal apoptosis was examined by morphological analysis, flow cyto…
  3. 03LabIn vitro (cells)Mechanism

    In cortical neurons, humanin significantly decreased the Abeta31-35-induced elevation of caspase-9 activity.

    In plain wordsIn cells, humanin lowered the rise in a second cell-death enzyme that amyloid beta caused in nerve cells.

    Peptide
    Humanin
    Outcome
    DecreaseCaspase-9 activity
    Study

    n: not reported in source

    Primary cultured cortical neurons exposed to Abeta31-35
    Comparator
    Abeta31-35 alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    (2) HN significantly decreased Abeta31-35-induced elevation of caspase-3 and -9 activities
    1 context sentence
    Summary · context
    Cultured cortical neurons were pretreated with different concentrations of HN (5, 10, 20 micromol/L) for different time period (0, 8 and 16 h) respectively, and then exposed to Abeta31-35 (25 micromol/L) for additional 24 h and the neuronal apoptosis was examined by morphological analysis, flow cyto…
  4. 04LabIn vitro (cells)Mechanism

    In cortical neurons, humanin suppressed Abeta31-35-induced translocation of Bax from the cytosol to mitochondria.

    In plain wordsIn cells, humanin stopped a cell-death protein from moving into the energy-making parts of nerve cells.

    Peptide
    Humanin
    Outcome
    DecreaseBax translocation to mitochondria
    Study

    n: not reported in source

    Primary cultured cortical neurons exposed to Abeta31-35
    Comparator
    Abeta31-35 alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    (3) HN suppressed Abeta31-35-induced translocation of Bax from the cytosol to mitochondria
    1 context sentence
    Summary · context
    Cultured cortical neurons were pretreated with different concentrations of HN (5, 10, 20 micromol/L) for different time period (0, 8 and 16 h) respectively, and then exposed to Abeta31-35 (25 micromol/L) for additional 24 h and the neuronal apoptosis was examined by morphological analysis, flow cyto…
  5. 05LabIn vitro (cells)Mechanism

    In cortical neurons, humanin had no effect on overall Bax expression.

    In plain wordsIn cells, humanin did not change the total amount of the cell-death protein Bax.

    Peptide
    Humanin
    Outcome
    No significant changeOverall Bax expression
    Study

    n: not reported in source

    Primary cultured cortical neurons exposed to Abeta31-35
    Comparator
    Abeta31-35 alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but had no effect on overall Bax expression.
    1 context sentence
    Summary · context
    Cultured cortical neurons were pretreated with different concentrations of HN (5, 10, 20 micromol/L) for different time period (0, 8 and 16 h) respectively, and then exposed to Abeta31-35 (25 micromol/L) for additional 24 h and the neuronal apoptosis was examined by morphological analysis, flow cyto…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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