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Study · Animal study (in vivo) · 2009

2 results

Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing.

Brcic L, Brcic I, Staresinic M, Novinscak T, Sikiric P, Seiwerth S

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Dec 2009Cited by 29 (Europe PMC)

PMID20388964 (opens in a new tab)DOI10.1135/css200911118 (opens in a new tab)PepBankPUB-20388964
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In animals with crushed or transected muscle and tendon, BPC‑157 treatment gave adequately modulated angiogenesis on VEGF, CD34 and FVIII staining, with more adequate healing.

    In plain wordsIn animals with muscle and tendon injuries, BPC‑157 gave adequately modulated blood vessel growth and more adequate healing.

    Peptide
    BPC-157
    Outcome
    MixedAngiogenesis in muscle and tendon healing (VEGF, CD34, FVIII)
    Study

    n: not reported in source

    Crushed muscle and transected muscle and tendon
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the other hand, immunohistochemical analysis of muscle and tendon healing using VEGF, CD34 and FVIII antibodies showed adequately modulated angiogenesis in BPC 157 treated animals, resulting in a more adequate healing.
    1 context sentence
    Summary · context
    We correlated the angiogenic effect of BPC 157 with VEGF expression using in vitro (cell culture) and in vivo (crushed muscle and transected muscle and tendon) models.
  2. 02LabIn vitro (cells)Mechanism

    In cell cultures, BPC‑157 had no direct angiogenic effect.

    In plain wordsIn cells in the lab, BPC‑157 had no direct effect on new blood vessel growth.

    Peptide
    BPC-157
    Outcome
    No significant changeDirect angiogenic effect in cell culture
    Study

    n: not reported in source

    Cell culture
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Results revealed that there is no direct angiogenic effect of BPC 157 on cell cultures.
    1 context sentence
    Summary · context
    We correlated the angiogenic effect of BPC 157 with VEGF expression using in vitro (cell culture) and in vivo (crushed muscle and transected muscle and tendon) models.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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