Skip to content

Study · Animal study (in vivo) · mouse · 2009

3 results

Gastric pentadecapeptide BPC 157 counteracts morphine-induced analgesia in mice.

Boban Blagaic A, Turcic P, Blagaic V, Dubovecak M, Jelovac N, Zemba M, Radic B, Becejac T, Stancic Rokotov D, Sikiric P

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Dec 2009Cited by 11 (Europe PMC)

PMID20388962 (opens in a new tab)PepBankPUB-20388962
Publisher pageAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice in the hot plate test, BPC‑157 counteracted the analgesia caused by morphine; the effect needed 30 minutes to develop.

    In plain wordsIn mice, BPC‑157 reduced the pain relief given by morphine. The effect took 30 minutes to develop.

    Peptide
    BPC-157
    Outcome
    DecreaseMorphine-induced analgesia (hot plate reaction time)
    Study

    mousen: not reported in source

    Hot plate test, morphine-induced antinociception
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    10 pg/kg, 10 ng/kg, 10 microg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    Time to onset of BPC 157 action
    30 minutes
    morphine-induced analgesia

    Source sentences

    Summary
    It was found that naloxone and BPC 157 counteracted the morphine (16 mg/kg s.c.) - analgesia.
    2 context sentences
    Summary · context
    the development of BPC 157-induced action (10 pg/kg, 10 ng/kg, 10 microg/kg i.p.) required 30 minutes
    Summary · context
    The present study aimed to study the effect of naloxone and BPC 157 on morphine-induced antinociceptive action in hot plate test in the mouse.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, BPC‑157 counteracted the enhancement of morphine analgesia caused by haloperidol.

    In plain wordsIn mice, BPC‑157 reduced the extra pain relief that haloperidol added to morphine.

    Peptide
    BPC-157
    Outcome
    DecreaseHaloperidol-enhanced morphine analgesia
    Study

    mousen: not reported in source

    Hot plate test, morphine-induced antinociception
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When haloperidol, a central dopamine-antagonist (1 mg/kg i.p.), enhanced morphine-analgesia, BPC 157 counteracted this enhancement
    1 context sentence
    Summary · context
    The present study aimed to study the effect of naloxone and BPC 157 on morphine-induced antinociceptive action in hot plate test in the mouse.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice in the hot plate test, BPC‑157 alone did not produce analgesia.

    In plain wordsIn mice, BPC‑157 given alone did not give any pain relief.

    Peptide
    BPC-157
    Outcome
    No significant changeAnalgesic action of BPC 157 alone
    Study

    mousen: not reported in source

    Hot plate test, morphine-induced antinociception
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157, naloxone, and haloperidol per se failed to exert analgesic action.
    1 context sentence
    Summary · context
    The present study aimed to study the effect of naloxone and BPC 157 on morphine-induced antinociceptive action in hot plate test in the mouse.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.