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Study · Animal study (in vivo) · rat · 2009

4 results

Antiinflammatory effect of BPC 157 on experimental periodontitis in rats.

Keremi B, Lohinai Z, Komora P, Duhaj S, Borsi K, Jobbagy-Ovari G, Kallo K, Szekely AD, Fazekas A, Dobo-Nagy C, Sikiric P, Varga G

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Dec 2009Cited by 25 (Europe PMC)

PMID20388954 (opens in a new tab)PepBankPUB-20388954
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In healthy rats, BPC‑157 had no effect on gingivomucosal blood flow.

    In plain wordsIn rats, BPC‑157 did not change blood flow in the gums.

    Peptide
    BPC-157
    Outcome
    No significant changeGingivomucosal blood flow
    Study

    ratn: not reported in source

    Healthy rat gingiva
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157 had no effect on gingivomucosal blood flow.
    1 context sentence
    Summary · context
    First the acute effect of BPC was tested on gingival blood flow by laser doppler flowmetry.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ligature-induced periodontitis, BPC‑157 reduced plasma extravasation in gingivomucosal tissue.

    In plain wordsIn rats with gum disease, BPC‑157 reduced leakage of plasma into gum tissue compared with vehicle.

    Peptide
    BPC-157
    Outcome
    DecreaseEvans blue plasma extravasation in gingivomucosal tissue
    Study

    ratn: not reported in source

    Ligature-induced periodontitis
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · 12 daysAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 treatment significantly reduced both plasma extravasation, histological alterations and alveolar bone resorption.
    1 context sentence
    Summary · context
    Rats were treated with BPC 157 (once daily for 12 days) or vehicle.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ligature-induced periodontitis, BPC‑157 reduced histological alterations of inflammation.

    In plain wordsIn rats with gum disease, BPC‑157 reduced signs of inflammation seen under the microscope compared with vehicle.

    Peptide
    BPC-157
    Outcome
    DecreaseHistological signs of inflammation
    Study

    ratn: not reported in source

    Ligature-induced periodontitis
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · 12 daysAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 treatment significantly reduced both plasma extravasation, histological alterations and alveolar bone resorption.
    1 context sentence
    Summary · context
    Rats were treated with BPC 157 (once daily for 12 days) or vehicle.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ligature-induced periodontitis, BPC‑157 reduced alveolar bone resorption.

    In plain wordsIn rats with gum disease, BPC‑157 reduced loss of jaw bone compared with vehicle.

    Peptide
    BPC-157
    Outcome
    DecreaseAlveolar bone resorption
    Study

    ratn: not reported in source

    Ligature-induced periodontitis
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 daysAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 treatment significantly reduced both plasma extravasation, histological alterations and alveolar bone resorption.
    1 context sentence
    Summary · context
    Rats were treated with BPC 157 (once daily for 12 days) or vehicle.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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