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Study · Animal study (in vivo) · rat · 2009

8 results

Over-dose insulin and stable gastric pentadecapeptide BPC 157. Attenuated gastric ulcers, seizures, brain lesions, hepatomegaly, fatty liver, breakdown of liver glycogen, profound hypoglycemia and calcification in rats.

Ilic S, Brcic I, Mester M, Filipovic M, Sever M, Klicek R, Barisic I, Radic B, Zoricic Z, Bilic V, Berkopic L, Brcic L and 5 more

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Kolenc D, Romic Z, Pazanin L, Seiwerth S, Sikiric P

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Dec 2009Cited by 38 (Europe PMC)

PMID20388953 (opens in a new tab)PepBankPUB-20388953
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats given an over-dose of insulin, BPC‑157 given after insulin was followed by no fatal outcome.

    In plain wordsIn rats given too much insulin, those given BPC‑157 afterwards did not die.

    Peptide
    BPC-157
    Outcome
    DecreaseFatal outcome after insulin over-dose
    Study

    ratn: not reported in source

    Over-dose insulin (250 IU/kg i.p.)
    Comparator
    Saline
    Outcome group
    Mortality · Whole body
    Studied dose
    10 microg/kg · intraperitoneal or intragastricAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 rats showed no fatal outcome
    3 context sentences
    Summary · context
    As an antidote after insulin, we applied the stable gastric pentadecapeptide BPC 157 (10 microg/kg) given (i) intraperitoneally or (ii) intragastrically immediately after insulin.
    Summary · context
    Controls received simultaneously an equivolume of saline (5 ml/kg).
    Summary · context
    Those rats that survived till the 180 minutes after over-dose application were further assessed.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats given an over-dose of insulin, BPC‑157 rats were mostly without hypoglycaemic seizures.

    In plain wordsIn rats given too much insulin, those given BPC‑157 mostly had no seizures from low blood sugar.

    Peptide
    BPC-157
    Outcome
    DecreaseHypoglycaemic seizures
    Study

    ratn: not reported in source

    Over-dose insulin (250 IU/kg i.p.)
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 microg/kg · intraperitoneal or intragastricAs given in this study (rat).

    Source sentences

    Summary
    they were mostly without hypoglycemic seizures with apparently higher blood glucose levels (glycogen was still present in hepatocytes), less liver pathology (i.e., normal liver weight, less fatty liver), decreased ALT, AST and amylase serum values, markedly less damaged neurons in brain and they onl…
    3 context sentences
    Summary · context
    As an antidote after insulin, we applied the stable gastric pentadecapeptide BPC 157 (10 microg/kg) given (i) intraperitoneally or (ii) intragastrically immediately after insulin.
    Summary · context
    Controls received simultaneously an equivolume of saline (5 ml/kg).
    Summary · context
    Those rats that survived till the 180 minutes after over-dose application were further assessed.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats given an over-dose of insulin, BPC‑157 rats had apparently higher blood glucose levels, and glycogen was still present in hepatocytes.

    In plain wordsIn rats given too much insulin, those given BPC‑157 had apparently higher blood sugar than controls.

    Peptide
    BPC-157
    Outcome
    IncreaseBlood glucose level
    Study

    ratn: not reported in source

    Over-dose insulin (250 IU/kg i.p.)
    Comparator
    Saline
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    10 microg/kg · intraperitoneal or intragastricAs given in this study (rat).

    Source sentences

    Summary
    apparently higher blood glucose levels (glycogen was still present in hepatocytes)
    3 context sentences
    Summary · context
    As an antidote after insulin, we applied the stable gastric pentadecapeptide BPC 157 (10 microg/kg) given (i) intraperitoneally or (ii) intragastrically immediately after insulin.
    Summary · context
    Controls received simultaneously an equivolume of saline (5 ml/kg).
    Summary · context
    Those rats that survived till the 180 minutes after over-dose application were further assessed.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats given an over-dose of insulin, BPC‑157 rats had less liver pathology: normal liver weight and less fatty liver.

    In plain wordsIn rats given too much insulin, those given BPC‑157 had less liver damage and less fatty liver than controls.

    Peptide
    BPC-157
    Outcome
    DecreaseLiver pathology (liver weight, fatty liver)
    Study

    ratn: not reported in source

    Over-dose insulin (250 IU/kg i.p.)
    Comparator
    Saline
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    10 microg/kg · intraperitoneal or intragastricAs given in this study (rat).

    Source sentences

    Summary
    less liver pathology (i.e., normal liver weight, less fatty liver)
    3 context sentences
    Summary · context
    As an antidote after insulin, we applied the stable gastric pentadecapeptide BPC 157 (10 microg/kg) given (i) intraperitoneally or (ii) intragastrically immediately after insulin.
    Summary · context
    Controls received simultaneously an equivolume of saline (5 ml/kg).
    Summary · context
    Those rats that survived till the 180 minutes after over-dose application were further assessed.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats given an over-dose of insulin, BPC‑157 decreased ALT, AST and amylase serum values.

    In plain wordsIn rats given too much insulin, BPC‑157 lowered blood levels of liver enzymes and amylase compared with controls.

    Peptide
    BPC-157
    Outcome
    DecreaseSerum ALT, AST and amylase
    Study

    ratn: not reported in source

    Over-dose insulin (250 IU/kg i.p.)
    Comparator
    Saline
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    10 microg/kg · intraperitoneal or intragastricAs given in this study (rat).

    Source sentences

    Summary
    decreased ALT, AST and amylase serum values, markedly less damaged neurons in brain and they only occasionally had small gastric lesions.
    3 context sentences
    Summary · context
    As an antidote after insulin, we applied the stable gastric pentadecapeptide BPC 157 (10 microg/kg) given (i) intraperitoneally or (ii) intragastrically immediately after insulin.
    Summary · context
    Controls received simultaneously an equivolume of saline (5 ml/kg).
    Summary · context
    Those rats that survived till the 180 minutes after over-dose application were further assessed.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats given an over-dose of insulin, BPC‑157 rats had markedly less damaged neurons in the brain.

    In plain wordsIn rats given too much insulin, those given BPC‑157 had much less damage to brain neurons than controls.

    Peptide
    BPC-157
    Outcome
    DecreaseNeuronal damage in brain
    Study

    ratn: not reported in source

    Over-dose insulin (250 IU/kg i.p.)
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 microg/kg · intraperitoneal or intragastricAs given in this study (rat).

    Source sentences

    Summary
    markedly less damaged neurons in brain and they only occasionally had small gastric lesions.
    3 context sentences
    Summary · context
    As an antidote after insulin, we applied the stable gastric pentadecapeptide BPC 157 (10 microg/kg) given (i) intraperitoneally or (ii) intragastrically immediately after insulin.
    Summary · context
    Controls received simultaneously an equivolume of saline (5 ml/kg).
    Summary · context
    Those rats that survived till the 180 minutes after over-dose application were further assessed.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats given an over-dose of insulin, BPC‑157 rats only occasionally had small gastric lesions.

    In plain wordsIn rats given too much insulin, those given BPC‑157 only occasionally had small stomach lesions.

    Peptide
    BPC-157
    Outcome
    DecreaseGastric lesions
    Study

    ratn: not reported in source

    Over-dose insulin (250 IU/kg i.p.)
    Comparator
    Saline
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 microg/kg · intraperitoneal or intragastricAs given in this study (rat).

    Source sentences

    Summary
    they only occasionally had small gastric lesions.
    3 context sentences
    Summary · context
    As an antidote after insulin, we applied the stable gastric pentadecapeptide BPC 157 (10 microg/kg) given (i) intraperitoneally or (ii) intragastrically immediately after insulin.
    Summary · context
    Controls received simultaneously an equivolume of saline (5 ml/kg).
    Summary · context
    Those rats that survived till the 180 minutes after over-dose application were further assessed.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats given an over-dose of insulin, BPC‑157 rats exhibited mostly only dot-like calcium presentation.

    In plain wordsIn rats given too much insulin, those given BPC‑157 mostly showed only small dot-like calcium deposits.

    Peptide
    BPC-157
    Outcome
    DecreaseCalcium deposits (calcification)
    Study

    ratn: not reported in source

    Over-dose insulin (250 IU/kg i.p.)
    Comparator
    Saline
    Outcome group
    Tissue calcification · Whole body
    Studied dose
    10 microg/kg · intraperitoneal or intragastricAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 rats exhibited mostly only dot-like calcium presentation.
    3 context sentences
    Summary · context
    As an antidote after insulin, we applied the stable gastric pentadecapeptide BPC 157 (10 microg/kg) given (i) intraperitoneally or (ii) intragastrically immediately after insulin.
    Summary · context
    Controls received simultaneously an equivolume of saline (5 ml/kg).
    Summary · context
    Those rats that survived till the 180 minutes after over-dose application were further assessed.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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