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Study · Non-randomized trial · n = 10 · 2010

5 results

Free alpha-subunit is the most sensitive marker of gonadotropin recovery after treatment of central precocious puberty with the histrelin implant.

Hirsch HJ, Lahlou N, Gillis D, Strich D, Rosenberg-Hagen B, Chertin B, Farkas A, Hartman H, Spitz IM

The Journal of clinical endocrinology and metabolism25 Mar 2010Cited by 10 (Europe PMC)

PMID20339028 (opens in a new tab)DOI10.1210/jc.2009-2078 (opens in a new tab)PepBankPUB-20339028
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In girls with CPP, FAS decreased from 1.19 ± 0.49 during histrelin treatment to 0.31 ± 0.12 ng/ml within one week of removal (P < 0.03).

    In plain wordsIn girls with CPP, FAS decreased within one week after histrelin implant removal.

    Peptide
    Histrelin
    Outcome
    DecreaseFAS after implant removal
    Study

    n = 10

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · 18-63 monthsAs given in this study (human).

    Measurements

    FAS during implant treatment (mean, SD 0.49)
    1.19 ng/ml
    all 10 girls
    FAS within 1 wk of implant removal (mean, SD 0.12)
    0.31 ng/ml
    all 10 girls

    Source sentences

    Summary
    FAS level (mean +/- SD) in all 10 girls during histrelin implant treatment was 1.19 +/- 0.49 ng/ml and rapidly decreased to 0.31 +/- 0.12 ng/ml within 1 wk of implant removal (P < 0.03).
    2 context sentences
    Summary · context
    Ten girls with CPP were studied.
    Summary · context
    Duration of implant treatment ranged from 18-63 months with repeated implant removals and insertions of new implants.
  2. 02HumanNon-randomized trialEfficacy outcome

    In girls with CPP, LH increased at 3 weeks after histrelin implant removal (P < 0.05).

    In plain wordsIn girls with CPP, LH increased at 3 weeks after histrelin implant removal.

    Peptide
    Histrelin
    Outcome
    IncreaseLH after implant removal
    Study

    n = 10

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · 18-63 monthsAs given in this study (human).

    Source sentences

    Summary
    In contrast, significant increases in LH (P < 0.05) and FSH (P < 0.02) were observed at 3 wk and E(2) (P < 0.05) at 6 wk after implant removal.
    2 context sentences
    Summary · context
    Ten girls with CPP were studied.
    Summary · context
    Duration of implant treatment ranged from 18-63 months with repeated implant removals and insertions of new implants.
  3. 03HumanNon-randomized trialEfficacy outcome

    In girls with CPP, FSH increased at 3 weeks after histrelin implant removal (P < 0.02).

    In plain wordsIn girls with CPP, FSH increased at 3 weeks after histrelin implant removal.

    Peptide
    Histrelin
    Outcome
    IncreaseFSH after implant removal
    Study

    n = 10

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · 18-63 monthsAs given in this study (human).

    Source sentences

    Summary
    In contrast, significant increases in LH (P < 0.05) and FSH (P < 0.02) were observed at 3 wk and E(2) (P < 0.05) at 6 wk after implant removal.
    2 context sentences
    Summary · context
    Ten girls with CPP were studied.
    Summary · context
    Duration of implant treatment ranged from 18-63 months with repeated implant removals and insertions of new implants.
  4. 04HumanNon-randomized trialEfficacy outcome

    In girls with CPP, estradiol increased at 6 weeks after histrelin implant removal (P < 0.05).

    In plain wordsIn girls with CPP, estradiol increased at 6 weeks after histrelin implant removal.

    Peptide
    Histrelin
    Outcome
    IncreaseEstradiol after implant removal
    Study

    n = 10

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · 18-63 monthsAs given in this study (human).

    Source sentences

    Summary
    In contrast, significant increases in LH (P < 0.05) and FSH (P < 0.02) were observed at 3 wk and E(2) (P < 0.05) at 6 wk after implant removal.
    2 context sentences
    Summary · context
    Ten girls with CPP were studied.
    Summary · context
    Duration of implant treatment ranged from 18-63 months with repeated implant removals and insertions of new implants.
  5. 05HumanNon-randomized trialEfficacy outcome

    In two treatment-naive girls with CPP, FAS increased from 0.2 and 0.4 to 2.4 and 5.1 ng/ml within 2-5 days of histrelin insertion.

    In plain wordsIn two untreated girls with CPP, FAS increased after histrelin implant insertion.

    Peptide
    Histrelin
    Outcome
    IncreaseFAS after initial implant insertion
    Study

    n = 2

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    FAS before insertion
    0.2 ng/ml
    first value for the two naive girls, before insertion
    FAS before insertion
    0.4 ng/ml
    second value for the two naive girls, before insertion
    FAS within 2-5 d of insertion
    2.4 ng/ml
    first value for the two naive girls
    FAS within 2-5 d of insertion
    5.1 ng/ml
    second value for the two naive girls

    Source sentences

    Summary
    FAS levels were 0.2 and 0.4 ng/ml (normal, <0.6 ng/ml) in the two naive girls and increased to 2.4 and 5.1 ng/ml within 2-5 d of insertion.
    2 context sentences
    Summary · context
    Ten girls with CPP were studied.
    Summary · context
    Duration of implant treatment ranged from 18-63 months with repeated implant removals and insertions of new implants.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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