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Study · Not a test of the peptide alone · 2010

5 results

Mutations of the KISS1 gene in disorders of puberty.

Silveira LG, Noel SD, Silveira-Neto AP, Abreu AP, Brito VN, Santos MG, Bianco SD, Kuohung W, Xu S, Gryngarten M, Escobar ME, Arnhold IJ, Mendonca BB, Kaiser UB, Latronico AC

The Journal of clinical endocrinology and metabolism17 Mar 2010Cited by 243 (Europe PMC)

PMID20237166 (opens in a new tab)PMCIDPMC2869552 (opens in a new tab)DOI10.1210/jc.2009-2421 (opens in a new tab)PepBankPUB-20237166
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-54 (metastin).

  1. 01HumanNot a test of Kisspeptin-54 (metastin) aloneObservational studyOther

    Both KISS1 mutations were absent in 400 control alleles.

    In plain wordsNeither KISS1 change was found in people with normal pubertal development.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    Not applicableKISS1 mutations in control individuals
    Study

    n = 200

    Comparator
    Controls with normal pubertal development
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Both mutations were absent in 400 control alleles.
    1 context sentence
    Summary · context
    The control group consisted of 200 individuals with normal pubertal development.

    In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).

  2. 02HumanNot a test of Kisspeptin-54 (metastin) aloneObservational studyOther

    In children with idiopathic central precocious puberty, two novel KISS1 missense mutations, p.P74S and p.H90D, were identified in three unrelated children.

    In plain wordsIn children with early puberty, two new changes in the KISS1 gene were found in three unrelated children.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    Not applicableKISS1 missense mutations in idiopathic CPP
    Study

    n = 83

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Two novel KISS1 missense mutations, p.P74S and p.H90D, were identified in three unrelated children with idiopathic CPP.
    1 context sentence
    Summary · context
    Eighty-three children with CPP (77 girls) and 61 patients with IHH (40 men) were studied.

    In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).

  3. 03HumanNot a test of Kisspeptin-54 (metastin) aloneObservational studyOther

    In patients with normosmic isolated hypogonadotropic hypogonadism, only polymorphisms were found in KISS1.

    In plain wordsIn patients with a hormone condition that affects puberty, only common gene variants were found in KISS1, not mutations.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    Not applicableKISS1 variants in normosmic IHH
    Study

    n = 61

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Only polymorphisms were found in the IHH group.
    1 context sentence
    Summary · context
    Eighty-three children with CPP (77 girls) and 61 patients with IHH (40 men) were studied.

    In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).

  4. 04LabNot a test of Kisspeptin-54 (metastin) aloneIn vitro (cells)Activity measurement

    In cells expressing KISS1R, the capacity of the P74S and H90D mutants to stimulate inositol phosphate production was similar to the wild type.

    In plain wordsIn cells, the two changed kisspeptin forms triggered receptor signalling about as well as the normal form.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeInositol phosphate production by mutant kp54
    Study

    humann: not reported in source

    cells expressing KISS1R
    Comparator
    Wild-type kp54
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    In vitro studies revealed that the capacity of the P74S and H90D mutants to stimulate IP production was similar to the wild type.
    1 context sentence
    Summary · context
    Cells expressing KISS1R were stimulated with synthetic human wild-type or mutant kisspeptin-54 (kp54), and inositol phosphate accumulation was measured.

    In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).

  5. 05LabNot a test of Kisspeptin-54 (metastin) aloneIn vitro (cells)Activity measurement

    After preincubation in human serum, the capacity of P74S kp54 to stimulate signal transduction was significantly greater than that of wild-type kp54.

    In plain wordsIn cells, the P74S form of kisspeptin kept its signalling better after time in human serum than the normal form.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseSignal transduction by P74S kp54 after serum preincubation
    Study

    humann: not reported in source

    cells expressing KISS1R with kp54 preincubated in human serum
    Comparator
    Wild-type kp54
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    After preincubation of wild-type and mutant kp54 in human serum, the capacity to stimulate signal transduction was significantly greater for P74S compared with the wild type, suggesting that the p.P74S variant is more stable.
    1 context sentence
    Summary · context
    In a second set of experiments, kp54 was preincubated in human serum before stimulation of the cells.

    In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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