Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat.

Cerovecki T, Bojanic I, Brcic L, Radic B, Vukoja I, Seiwerth S, Sikiric P

Journal of orthopaedic research : official publication of the Orthopaedic Research Society1 Sept 2010Cited by 39 (Europe PMC)

PMID20225319DOI10.1002/jor.21107PepBankPUB-20225319

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected medial collateral ligaments, BPC‑157 gave consistent improvements in functional healing.
In plain wordsIn rats with a cut knee ligament, BPC‑157 improved how well the ligament worked during healing.
Peptide
BPC-157
Outcome
IncreaseFunctional healing of medial collateral ligament
Study
ratn: not reported in source
Medial collateral ligament transection
Outcome group
Tendon and ligament healing · Musculoskeletal
Studied dose
10 µg or 10 ng/kg intraperitoneally; 1.0 µg/g cream topically; 0.16 µg/ml in drinking water · intraperitoneal, topical or per-oral (drinking water) · Up to 90 daysAs given in this study (rat).
Source sentences
Summary
Commonly, BPC 157 microg-ng-rats exhibited consistent functional, biomechanical, macroscopic and histological healing improvements.
2 context sentences(design, population, supporting numbers)
Summary · context
We improved medial collateral ligament (MCL) healing throughout 90 days after surgical transection.
Summary · context
After MCL transection BPC 157 was effective in rats when given once daily intraperitoneally (10 microg or 10 ng/kg) or locally as a thin layer (1.0 microg dissolved in distilled water/g commercial neutral cream) at the site of injury, first application 30 min after surgery and the final application…
Report a problemFND-2022531901
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected medial collateral ligaments, BPC‑157 gave consistent improvements in biomechanical healing.
In plain wordsIn rats with a cut knee ligament, BPC‑157 improved the strength of the healing ligament.
Peptide
BPC-157
Outcome
IncreaseBiomechanical healing of medial collateral ligament
Study
ratn: not reported in source
Medial collateral ligament transection
Outcome group
Tendon and ligament healing · Musculoskeletal
Studied dose
10 µg or 10 ng/kg intraperitoneally; 1.0 µg/g cream topically; 0.16 µg/ml in drinking water · intraperitoneal, topical or per-oral (drinking water) · Up to 90 daysAs given in this study (rat).
Source sentences
Summary
Commonly, BPC 157 microg-ng-rats exhibited consistent functional, biomechanical, macroscopic and histological healing improvements.
2 context sentences(design, population, supporting numbers)
Summary · context
We improved medial collateral ligament (MCL) healing throughout 90 days after surgical transection.
Summary · context
After MCL transection BPC 157 was effective in rats when given once daily intraperitoneally (10 microg or 10 ng/kg) or locally as a thin layer (1.0 microg dissolved in distilled water/g commercial neutral cream) at the site of injury, first application 30 min after surgery and the final application…
Report a problemFND-2022531902
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected medial collateral ligaments, BPC‑157 gave consistent improvements in macroscopic healing.
In plain wordsIn rats with a cut knee ligament, BPC‑157 improved how the healing ligament looked to the eye.
Peptide
BPC-157
Outcome
IncreaseMacroscopic healing of medial collateral ligament
Study
ratn: not reported in source
Medial collateral ligament transection
Outcome group
Tendon and ligament healing · Musculoskeletal
Studied dose
10 µg or 10 ng/kg intraperitoneally; 1.0 µg/g cream topically; 0.16 µg/ml in drinking water · intraperitoneal, topical or per-oral (drinking water) · Up to 90 daysAs given in this study (rat).
Source sentences
Summary
Commonly, BPC 157 microg-ng-rats exhibited consistent functional, biomechanical, macroscopic and histological healing improvements.
2 context sentences(design, population, supporting numbers)
Summary · context
We improved medial collateral ligament (MCL) healing throughout 90 days after surgical transection.
Summary · context
After MCL transection BPC 157 was effective in rats when given once daily intraperitoneally (10 microg or 10 ng/kg) or locally as a thin layer (1.0 microg dissolved in distilled water/g commercial neutral cream) at the site of injury, first application 30 min after surgery and the final application…
Report a problemFND-2022531903
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with transected medial collateral ligaments, BPC‑157 gave consistent improvements in histological healing.
In plain wordsIn rats with a cut knee ligament, BPC‑157 improved how the healing ligament looked under the microscope.
Peptide
BPC-157
Outcome
IncreaseHistological healing of medial collateral ligament
Study
ratn: not reported in source
Medial collateral ligament transection
Outcome group
Tendon and ligament healing · Musculoskeletal
Studied dose
10 µg or 10 ng/kg intraperitoneally; 1.0 µg/g cream topically; 0.16 µg/ml in drinking water · intraperitoneal, topical or per-oral (drinking water) · Up to 90 daysAs given in this study (rat).
Source sentences
Summary
Commonly, BPC 157 microg-ng-rats exhibited consistent functional, biomechanical, macroscopic and histological healing improvements.
2 context sentences(design, population, supporting numbers)
Summary · context
We improved medial collateral ligament (MCL) healing throughout 90 days after surgical transection.
Summary · context
After MCL transection BPC 157 was effective in rats when given once daily intraperitoneally (10 microg or 10 ng/kg) or locally as a thin layer (1.0 microg dissolved in distilled water/g commercial neutral cream) at the site of injury, first application 30 min after surgery and the final application…
Report a problemFND-2022531904

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

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MeSH terms

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