Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes.

Koska J, Schwartz EA, Mullin MP, Schwenke DC, Reaven PD

Diabetes care3 Mar 2010Cited by 104 (Europe PMC)

PMID20200309PMCIDPMC2858168DOI10.2337/dc09-1961PepBankPUB-20200309

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

01HumanRandomized controlled trialEfficacy outcome
In individuals with impaired glucose tolerance or recent-onset diabetes, exenatide improved postprandial endothelial function compared with placebo.
In plain wordsIn people with impaired glucose tolerance or recent diabetes, exenatide improved blood vessel function after a meal compared with placebo.
Peptide
Exenatide (exendin-4)
Outcome
IncreasePostprandial endothelial function
Study
n = 28
Comparator
placebo
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated · injection · single doseAs given in this study (human).
Source sentences
Summary
Postprandial endothelial function was higher after exenatide compared with placebo (P = 0.0002).
1 context sentence(design, population, supporting numbers)
Summary · context
In a double-blinded randomized crossover design, postprandial endothelial function was examined in 28 individuals with impaired glucose tolerance or recent-onset type 2 diabetes after a single injection of exenatide or placebo given just before a high-fat meal.
Report a problemFND-2020030901
02HumanRandomized controlled trialMechanism
In individuals with impaired glucose tolerance or recent-onset diabetes, triglyceride changes explained 64% of exenatide's postprandial endothelial effect.
In plain wordsIn people with impaired glucose tolerance or recent diabetes, triglyceride changes explained part of exenatide's blood vessel effect compared with placebo.
Peptide
Exenatide (exendin-4)
Outcome
Not applicableTriglyceride mediation of endothelial effect
Study
n = 28
Comparator
placebo
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated · injection · single doseAs given in this study (human).
Measurements
Effect explained
64%
postprandial triglyceride changes
Source sentences
Summary
Changes in postprandial triglyceride concentrations explained 64% of exenatide's effect on postprandial endothelial function.
1 context sentence(design, population, supporting numbers)
Summary · context
In a double-blinded randomized crossover design, postprandial endothelial function was examined in 28 individuals with impaired glucose tolerance or recent-onset type 2 diabetes after a single injection of exenatide or placebo given just before a high-fat meal.
Report a problemFND-2020030902

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 4NCT00974272

Effects of Exenatide on Postprandial Hyperlipidemia and Inflammation

Carl T. Hayden VA Medical Centern = 39Aug 2006 to Nov 2008

Type 2 Diabetes Mellitus · Impaired Glucose Tolerance

Trial page ClinicalTrials.govUpdated 10 Sept 2009

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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