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Study · Animal study (in vivo) · rat · 2010

2 results

Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application.

Pevec D, Novinscak T, Brcic L, Sipos K, Jukic I, Staresinic M, Mise S, Brcic I, Kolenc D, Klicek R, Banic T, Sever M and 9 more

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Kocijan A, Berkopic L, Radic B, Buljat G, Anic T, Zoricic I, Bojanic I, Seiwerth S, Sikiric P

Medical science monitor : international medical journal of experimental and clinical research1 Mar 2010Cited by 28 (Europe PMC)

PMID20190676 (opens in a new tab)PepBankPUB-20190676
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with gastrocnemius muscle crush injury, BPC‑157 induced faster muscle healing and full function restoration than untreated injured controls.

    In plain wordsIn rats with a crushed calf muscle, BPC‑157 gave faster healing and full return of function than no treatment.

    Peptide
    BPC-157
    Outcome
    IncreaseMuscle healing speed and function restoration
    Study

    ratn: not reported in source

    Gastrocnemius muscle complex crush injury
    Comparator
    Untreated injured controls
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · intraperitoneal or local creamAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 induced faster muscle healing and full function restoration
    2 context sentences
    Summary · context
    After the gastrocnemius muscle complex had been injured, rats received BPC 157 (intraperitoneally or locally as a cream) and/or 6alpha-methylprednisolone (intraperitoneally) only once (immediately after injury, sacrifice at 2 h) or once daily (final dose 24 hours before sacrifice and/or assessment p…
    Summary · context
    Muscle healing was evaluated functionally, macroscopically, and histologically.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats given 6alpha-methylprednisolone after muscle crush injury, BPC‑157 improved muscle healing despite the corticosteroid, given intraperitoneally or locally.

    In plain wordsIn rats with a crushed calf muscle treated with a corticosteroid, BPC‑157 still improved muscle healing.

    Peptide
    BPC-157
    Outcome
    IncreaseMuscle healing despite systemic corticosteroid treatment
    Study

    ratn: not reported in source

    Gastrocnemius muscle complex crush injury
    Comparator
    6alpha-methylprednisolone alone
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · intraperitoneal or local creamAs given in this study (rat).

    Source sentences

    Summary
    improved muscle healing despite systemic corticosteroid treatment when given intraperitoneally or locally
    2 context sentences
    Summary · context
    After the gastrocnemius muscle complex had been injured, rats received BPC 157 (intraperitoneally or locally as a cream) and/or 6alpha-methylprednisolone (intraperitoneally) only once (immediately after injury, sacrifice at 2 h) or once daily (final dose 24 hours before sacrifice and/or assessment p…
    Summary · context
    Muscle healing was evaluated functionally, macroscopically, and histologically.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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