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Study · In vitro (cells) · 2010

3 results

The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide.

Sookraj KA, Bowne WB, Adler V, Sarafraz-Yazdi E, Michl J, Pincus MR

Cancer chemotherapy and pharmacology25 Feb 2010Cited by 15 (Europe PMC)

PMID20182728 (opens in a new tab)DOI10.1007/s00280-009-1166-7 (opens in a new tab)PepBankPUB-20182728
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In MCF-7 cancer cells, intact labeled PNC‑27 produced punctate membrane fluorescence that increased during cell lysis.

    In plain wordsIn cells from breast cancer, intact labeled PNC‑27 accumulated in membrane spots as cells broke apart.

    Peptide
    PNC-27
    Outcome
    IncreaseIntact peptide localization during cancer cell lysis
    Study

    humann: not reported in source

    MCF-7 breast cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Measurements

    Observation time
    30 min
    cancer cell membrane fluorescence

    Source sentences

    Summary
    At 30 min, there is significant combined punctate yellow fluorescence, indicative of intact peptide, in the cell membrane of cancer cells that increases during cancer cell lysis.
    1 context sentence
    Summary · context
    We have prepared PNC-27 with a green fluorescent label on its amino terminus and a red fluorescent label on its carboxyl terminus and treated MCF-7 breast cancer cells and untransformed MCF-10-2A breast epithelial cells with this double-labeled peptide to determine if combined yellow fluorescence oc…
  2. 02LabIn vitro (cells)Mechanism

    In untransformed MCF-10-2A cells, labeled PNC‑27 produced initial uniform membrane fluorescence that subsequently disappeared.

    In plain wordsIn cells from a normal breast epithelial line, labeled PNC‑27 initially appeared across membranes, then disappeared.

    Peptide
    PNC-27
    Outcome
    MixedTransient normal cell membrane localization
    Study

    humann: not reported in source

    MCF-10-2A breast epithelial cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Measurements

    Initial observation time
    30 min
    MCF-10-2A membrane fluorescence

    Source sentences

    Summary
    MCF-10-2A cells show initial (30 min) uniform combined yellow membrane fluorescence that subsequently disappears.
    1 context sentence
    Summary · context
    We have prepared PNC-27 with a green fluorescent label on its amino terminus and a red fluorescent label on its carboxyl terminus and treated MCF-7 breast cancer cells and untransformed MCF-10-2A breast epithelial cells with this double-labeled peptide to determine if combined yellow fluorescence oc…
  3. 03LabIn vitro (cells)Safety outcome

    In untransformed MCF-10-2A cells, viability persisted during PNC‑27 exposure, unlike the cancer cells.

    In plain wordsIn cells from a normal breast epithelial line, cells remained alive during PNC‑27 exposure, unlike cancer cells.

    Peptide
    PNC-27
    Outcome
    No significant changeNormal cell viability
    Study

    humann: not reported in source

    MCF-10-2A breast epithelial cells
    Outcome group
    Adverse events · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Unlike the cancer cells, these untransformed cells remain viable.
    1 context sentence
    Summary · context
    We have prepared PNC-27 with a green fluorescent label on its amino terminus and a red fluorescent label on its carboxyl terminus and treated MCF-7 breast cancer cells and untransformed MCF-10-2A breast epithelial cells with this double-labeled peptide to determine if combined yellow fluorescence oc…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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