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Study · Randomized controlled trial · n = 15 · 2010

13 results

A dose-finding study of methylene blue to inhibit nitric oxide actions in the hemodynamics of human septic shock.

Juffermans NP, Vervloet MG, Daemen-Gubbels CR, Binnekade JM, de Jong M, Groeneveld AB

Nitric oxide : biology and chemistry28 Jan 2010Cited by 69 (Europe PMC)

PMID20109575 (opens in a new tab)DOI10.1016/j.niox.2010.01.006 (opens in a new tab)PepBankPUB-20109575
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. 13 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In septic shock patients, methylene blue increased heart rate after infusion.

    In plain wordsIn patients with septic shock, methylene blue increased heart rate compared with before infusion.

    Peptide
    Methylene blue
    Outcome
    IncreaseHeart rate
    Study

    n = 15

    Comparator
    Before infusion
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1, 3 or 7 mg/kg · infusion · 20 minAs given in this study (human).

    Source sentences

    Summary
    Methylene blue treatment increased heart rate, cardiac index, mean arterial, pulmonary artery, pulmonary artery occlusion and central venous pressures, systemic vascular resistance, ventricular stroke work indices and O(2) delivery and uptake, and decreased lactate levels.
    2 context sentences
    Summary · context
    To evaluate dose-dependency, a prospective, randomized, double blind, single centre study was performed in 15 consecutive, mechanically ventilated patients with septic shock admitted to the intensive care unit
    Summary · context
    in whom methylene blue was infused at 1 mg/kg (n=4), 3 mg/kg (n=6) or 7 mg/kg (n=5) over 20 min.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In septic shock patients, methylene blue increased cardiac index with a dose-dependent effect.

    In plain wordsIn patients with septic shock, methylene blue increased cardiac index compared with before infusion, with a dose-dependent effect.

    Peptide
    Methylene blue
    Outcome
    IncreaseCardiac index
    Study

    n = 15

    Comparator
    Before infusion
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1, 3 or 7 mg/kg · infusion · 20 minAs given in this study (human).

    Source sentences

    Summary
    Methylene blue treatment increased heart rate, cardiac index, mean arterial, pulmonary artery, pulmonary artery occlusion and central venous pressures, systemic vascular resistance, ventricular stroke work indices and O(2) delivery and uptake, and decreased lactate levels.
    3 context sentences
    Summary · context
    Methylene blue had a dose-dependent effect on cardiac index, mean arterial, mean pulmonary artery and pulmonary artery occlusion pressures, left ventricular function, O(2) delivery and consumption and lactate levels.
    Summary · context
    To evaluate dose-dependency, a prospective, randomized, double blind, single centre study was performed in 15 consecutive, mechanically ventilated patients with septic shock admitted to the intensive care unit
    Summary · context
    in whom methylene blue was infused at 1 mg/kg (n=4), 3 mg/kg (n=6) or 7 mg/kg (n=5) over 20 min.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In septic shock patients, methylene blue increased mean arterial pressure with a dose-dependent effect.

    In plain wordsIn patients with septic shock, methylene blue increased mean arterial pressure compared with before infusion, with a dose-dependent effect.

    Peptide
    Methylene blue
    Outcome
    IncreaseMean arterial pressure
    Study

    n = 15

    Comparator
    Before infusion
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1, 3 or 7 mg/kg · infusion · 20 minAs given in this study (human).

    Source sentences

    Summary
    Methylene blue treatment increased heart rate, cardiac index, mean arterial, pulmonary artery, pulmonary artery occlusion and central venous pressures, systemic vascular resistance, ventricular stroke work indices and O(2) delivery and uptake, and decreased lactate levels.
    3 context sentences
    Summary · context
    Methylene blue had a dose-dependent effect on cardiac index, mean arterial, mean pulmonary artery and pulmonary artery occlusion pressures, left ventricular function, O(2) delivery and consumption and lactate levels.
    Summary · context
    To evaluate dose-dependency, a prospective, randomized, double blind, single centre study was performed in 15 consecutive, mechanically ventilated patients with septic shock admitted to the intensive care unit
    Summary · context
    in whom methylene blue was infused at 1 mg/kg (n=4), 3 mg/kg (n=6) or 7 mg/kg (n=5) over 20 min.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In septic shock patients, methylene blue increased pulmonary artery pressure with a dose-dependent effect.

    In plain wordsIn patients with septic shock, methylene blue increased pulmonary artery pressure compared with before infusion, with a dose-dependent effect.

    Peptide
    Methylene blue
    Outcome
    IncreasePulmonary artery pressure
    Study

    n = 15

    Comparator
    Before infusion
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1, 3 or 7 mg/kg · infusion · 20 minAs given in this study (human).

    Source sentences

    Summary
    Methylene blue treatment increased heart rate, cardiac index, mean arterial, pulmonary artery, pulmonary artery occlusion and central venous pressures, systemic vascular resistance, ventricular stroke work indices and O(2) delivery and uptake, and decreased lactate levels.
    3 context sentences
    Summary · context
    Methylene blue had a dose-dependent effect on cardiac index, mean arterial, mean pulmonary artery and pulmonary artery occlusion pressures, left ventricular function, O(2) delivery and consumption and lactate levels.
    Summary · context
    To evaluate dose-dependency, a prospective, randomized, double blind, single centre study was performed in 15 consecutive, mechanically ventilated patients with septic shock admitted to the intensive care unit
    Summary · context
    in whom methylene blue was infused at 1 mg/kg (n=4), 3 mg/kg (n=6) or 7 mg/kg (n=5) over 20 min.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In septic shock patients, methylene blue increased pulmonary artery occlusion pressure with a dose-dependent effect.

    In plain wordsIn patients with septic shock, methylene blue increased pulmonary artery occlusion pressure compared with before infusion, with a dose-dependent effect.

    Peptide
    Methylene blue
    Outcome
    IncreasePulmonary artery occlusion pressure
    Study

    n = 15

    Comparator
    Before infusion
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1, 3 or 7 mg/kg · infusion · 20 minAs given in this study (human).

    Source sentences

    Summary
    Methylene blue treatment increased heart rate, cardiac index, mean arterial, pulmonary artery, pulmonary artery occlusion and central venous pressures, systemic vascular resistance, ventricular stroke work indices and O(2) delivery and uptake, and decreased lactate levels.
    3 context sentences
    Summary · context
    Methylene blue had a dose-dependent effect on cardiac index, mean arterial, mean pulmonary artery and pulmonary artery occlusion pressures, left ventricular function, O(2) delivery and consumption and lactate levels.
    Summary · context
    To evaluate dose-dependency, a prospective, randomized, double blind, single centre study was performed in 15 consecutive, mechanically ventilated patients with septic shock admitted to the intensive care unit
    Summary · context
    in whom methylene blue was infused at 1 mg/kg (n=4), 3 mg/kg (n=6) or 7 mg/kg (n=5) over 20 min.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In septic shock patients, methylene blue increased central venous pressure after infusion.

    In plain wordsIn patients with septic shock, methylene blue increased central venous pressure compared with before infusion.

    Peptide
    Methylene blue
    Outcome
    IncreaseCentral venous pressure
    Study

    n = 15

    Comparator
    Before infusion
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1, 3 or 7 mg/kg · infusion · 20 minAs given in this study (human).

    Source sentences

    Summary
    Methylene blue treatment increased heart rate, cardiac index, mean arterial, pulmonary artery, pulmonary artery occlusion and central venous pressures, systemic vascular resistance, ventricular stroke work indices and O(2) delivery and uptake, and decreased lactate levels.
    2 context sentences
    Summary · context
    To evaluate dose-dependency, a prospective, randomized, double blind, single centre study was performed in 15 consecutive, mechanically ventilated patients with septic shock admitted to the intensive care unit
    Summary · context
    in whom methylene blue was infused at 1 mg/kg (n=4), 3 mg/kg (n=6) or 7 mg/kg (n=5) over 20 min.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In septic shock patients, methylene blue increased systemic vascular resistance after infusion.

    In plain wordsIn patients with septic shock, methylene blue increased systemic vascular resistance compared with before infusion.

    Peptide
    Methylene blue
    Outcome
    IncreaseSystemic vascular resistance
    Study

    n = 15

    Comparator
    Before infusion
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1, 3 or 7 mg/kg · infusion · 20 minAs given in this study (human).

    Source sentences

    Summary
    Methylene blue treatment increased heart rate, cardiac index, mean arterial, pulmonary artery, pulmonary artery occlusion and central venous pressures, systemic vascular resistance, ventricular stroke work indices and O(2) delivery and uptake, and decreased lactate levels.
    2 context sentences
    Summary · context
    To evaluate dose-dependency, a prospective, randomized, double blind, single centre study was performed in 15 consecutive, mechanically ventilated patients with septic shock admitted to the intensive care unit
    Summary · context
    in whom methylene blue was infused at 1 mg/kg (n=4), 3 mg/kg (n=6) or 7 mg/kg (n=5) over 20 min.
  8. 08HumanRandomized controlled trialEfficacy outcome

    In septic shock patients, methylene blue increased ventricular stroke work indices after infusion.

    In plain wordsIn patients with septic shock, methylene blue increased ventricular stroke work indices compared with before infusion.

    Peptide
    Methylene blue
    Outcome
    IncreaseVentricular stroke work indices
    Study

    n = 15

    Comparator
    Before infusion
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1, 3 or 7 mg/kg · infusion · 20 minAs given in this study (human).

    Source sentences

    Summary
    Methylene blue treatment increased heart rate, cardiac index, mean arterial, pulmonary artery, pulmonary artery occlusion and central venous pressures, systemic vascular resistance, ventricular stroke work indices and O(2) delivery and uptake, and decreased lactate levels.
    2 context sentences
    Summary · context
    To evaluate dose-dependency, a prospective, randomized, double blind, single centre study was performed in 15 consecutive, mechanically ventilated patients with septic shock admitted to the intensive care unit
    Summary · context
    in whom methylene blue was infused at 1 mg/kg (n=4), 3 mg/kg (n=6) or 7 mg/kg (n=5) over 20 min.
  9. 09HumanRandomized controlled trialEfficacy outcome

    In septic shock patients, methylene blue increased oxygen delivery with a dose-dependent effect.

    In plain wordsIn patients with septic shock, methylene blue increased oxygen delivery compared with before infusion, with a dose-dependent effect.

    Peptide
    Methylene blue
    Outcome
    IncreaseOxygen delivery
    Study

    n = 15

    Comparator
    Before infusion
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1, 3 or 7 mg/kg · infusion · 20 minAs given in this study (human).

    Source sentences

    Summary
    Methylene blue treatment increased heart rate, cardiac index, mean arterial, pulmonary artery, pulmonary artery occlusion and central venous pressures, systemic vascular resistance, ventricular stroke work indices and O(2) delivery and uptake, and decreased lactate levels.
    3 context sentences
    Summary · context
    Methylene blue had a dose-dependent effect on cardiac index, mean arterial, mean pulmonary artery and pulmonary artery occlusion pressures, left ventricular function, O(2) delivery and consumption and lactate levels.
    Summary · context
    To evaluate dose-dependency, a prospective, randomized, double blind, single centre study was performed in 15 consecutive, mechanically ventilated patients with septic shock admitted to the intensive care unit
    Summary · context
    in whom methylene blue was infused at 1 mg/kg (n=4), 3 mg/kg (n=6) or 7 mg/kg (n=5) over 20 min.
  10. 10HumanRandomized controlled trialEfficacy outcome

    In septic shock patients, methylene blue increased oxygen uptake with a dose-dependent effect on consumption.

    In plain wordsIn patients with septic shock, methylene blue increased oxygen uptake compared with before infusion, with a dose-dependent effect on consumption.

    Peptide
    Methylene blue
    Outcome
    IncreaseOxygen uptake and consumption
    Study

    n = 15

    Comparator
    Before infusion
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1, 3 or 7 mg/kg · infusion · 20 minAs given in this study (human).

    Source sentences

    Summary
    Methylene blue treatment increased heart rate, cardiac index, mean arterial, pulmonary artery, pulmonary artery occlusion and central venous pressures, systemic vascular resistance, ventricular stroke work indices and O(2) delivery and uptake, and decreased lactate levels.
    3 context sentences
    Summary · context
    Methylene blue had a dose-dependent effect on cardiac index, mean arterial, mean pulmonary artery and pulmonary artery occlusion pressures, left ventricular function, O(2) delivery and consumption and lactate levels.
    Summary · context
    To evaluate dose-dependency, a prospective, randomized, double blind, single centre study was performed in 15 consecutive, mechanically ventilated patients with septic shock admitted to the intensive care unit
    Summary · context
    in whom methylene blue was infused at 1 mg/kg (n=4), 3 mg/kg (n=6) or 7 mg/kg (n=5) over 20 min.
  11. 11HumanRandomized controlled trialEfficacy outcome

    In septic shock patients, methylene blue reduced lactate with a dose-dependent effect.

    In plain wordsIn patients with septic shock, methylene blue reduced lactate compared with before infusion, with a dose-dependent effect.

    Peptide
    Methylene blue
    Outcome
    DecreaseLactate
    Study

    n = 15

    Comparator
    Before infusion
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    1, 3 or 7 mg/kg · infusion · 20 minAs given in this study (human).

    Source sentences

    Summary
    Methylene blue treatment increased heart rate, cardiac index, mean arterial, pulmonary artery, pulmonary artery occlusion and central venous pressures, systemic vascular resistance, ventricular stroke work indices and O(2) delivery and uptake, and decreased lactate levels.
    3 context sentences
    Summary · context
    Methylene blue had a dose-dependent effect on cardiac index, mean arterial, mean pulmonary artery and pulmonary artery occlusion pressures, left ventricular function, O(2) delivery and consumption and lactate levels.
    Summary · context
    To evaluate dose-dependency, a prospective, randomized, double blind, single centre study was performed in 15 consecutive, mechanically ventilated patients with septic shock admitted to the intensive care unit
    Summary · context
    in whom methylene blue was infused at 1 mg/kg (n=4), 3 mg/kg (n=6) or 7 mg/kg (n=5) over 20 min.
  12. 12HumanRandomized controlled trialEfficacy outcome

    In septic shock patients, methylene blue had a dose-dependent effect on left ventricular function.

    In plain wordsIn patients with septic shock, methylene blue had a dose-dependent effect on left ventricular function.

    Peptide
    Methylene blue
    Outcome
    Direction not reportedLeft ventricular function
    Study

    n = 15

    Comparator
    Other methylene blue doses
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1, 3 or 7 mg/kg · infusion · 20 minAs given in this study (human).

    Source sentences

    Summary
    Methylene blue had a dose-dependent effect on cardiac index, mean arterial, mean pulmonary artery and pulmonary artery occlusion pressures, left ventricular function, O(2) delivery and consumption and lactate levels.
    2 context sentences
    Summary · context
    To evaluate dose-dependency, a prospective, randomized, double blind, single centre study was performed in 15 consecutive, mechanically ventilated patients with septic shock admitted to the intensive care unit
    Summary · context
    in whom methylene blue was infused at 1 mg/kg (n=4), 3 mg/kg (n=6) or 7 mg/kg (n=5) over 20 min.
  13. 13HumanRandomized controlled trialSafety outcome

    In septic shock patients, methylene blue dose-dependently increased the gastric-arterial blood carbon dioxide gap.

    In plain wordsIn patients with septic shock, methylene blue increased the gastric-arterial carbon dioxide gap, and the increase depended on the dose.

    Peptide
    Methylene blue
    Outcome
    IncreaseGastric-arterial blood carbon dioxide gap
    Study

    n = 15

    Outcome group
    Adverse events · Gastrointestinal
    Studied dose
    1, 3 or 7 mg/kg · infusion · 20 minAs given in this study (human).

    Source sentences

    Summary
    The drug dose-dependently increased the gastric-arterial blood PCO(2) gap.
    2 context sentences
    Summary · context
    To evaluate dose-dependency, a prospective, randomized, double blind, single centre study was performed in 15 consecutive, mechanically ventilated patients with septic shock admitted to the intensive care unit
    Summary · context
    in whom methylene blue was infused at 1 mg/kg (n=4), 3 mg/kg (n=6) or 7 mg/kg (n=5) over 20 min.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 4NCT03120637

Evaluating in Cirrhotics With Refractory Vasoplegia the Effect of Methylene Blue

Institute of Liver and Biliary Sciences, Indian = 1111 Jan 2017 to 10 Jan 2018

Septic Shock · Vasoplegia · Cirrhosis, Liver · Refractory Shock

Trial pageClinicalTrials.govUpdated 30 Jan 2018

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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