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Study · Animal study (in vivo) · sheep · 2010

9 results

Insights into the mechanism by which kisspeptin stimulates a preovulatory LH surge and ovulation in seasonally acyclic ewes: potential role of estradiol.

Sébert ME, Lomet D, Saïd SB, Monget P, Briant C, Scaramuzzi RJ, Caraty A

Domestic animal endocrinology16 Jan 2010Cited by 48 (Europe PMC)

PMID20097511 (opens in a new tab)DOI10.1016/j.domaniend.2010.01.001 (opens in a new tab)PepBankPUB-20097511
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In seasonally acyclic ewes, a 43-h intravenous infusion of ovine kisspeptin‑10 induced a well-synchronized LH surge in 82% of animals.

    In plain wordsIn ewes outside the breeding season, an infusion of kisspeptin‑10 caused an LH surge in 82% of the animals.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseProportion of ewes with a preovulatory-type LH surge (experiment 1)
    Study

    sheepn = 11

    seasonally acyclic ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    15.2 nmol/h · intravenous · 43 hAs given in this study (sheep).

    Measurements

    Ewes with LH surge
    82%
    experiment 1

    Source sentences

    Summary
    We found that the infusion of Kp induced a well-synchronized LH surge (around 22 h after the start of the Kp infusion) in 82% of the animals.
    1 context sentence
    Summary · context
    In the first experiment, a constant iv infusion of ovine kisspeptin 10 (Kp; 15.2 nmol/h) was given to 11 seasonally acyclic ewes over 43 h.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In ewes, LH surges during kisspeptin infusion were observed only in ewes that also had a sustained rise in plasma estradiol.

    In plain wordsIn ewes, LH surges after kisspeptin occurred only in animals that also had a lasting rise in estradiol.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseEstradiol rise in ewes with an LH surge (experiment 1)
    Study

    sheepn = 11

    seasonally acyclic ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    15.2 nmol/h · intravenous · 43 hAs given in this study (sheep).

    Source sentences

    Summary
    In the first experiment, surges of LH were observed only in ewes that also had a sustained rise in plasma concentrations of estradiol (E(2)) in response to Kp.
    1 context sentence
    Summary · context
    In the first experiment, a constant iv infusion of ovine kisspeptin 10 (Kp; 15.2 nmol/h) was given to 11 seasonally acyclic ewes over 43 h.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In seasonally acyclic ewes, kisspeptin infused for 24 h induced LH surges in 75% of animals.

    In plain wordsIn ewes outside the breeding season, a 24-hour kisspeptin infusion caused LH surges in 75% of animals.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH surge rate with 24-h kisspeptin infusion
    Study

    sheepn = 8

    seasonally acyclic ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    15.2 nmol/h · intravenous · 24 hAs given in this study (sheep).

    Measurements

    Ewes with LH surge
    75%
    24 h infusion

    Source sentences

    Summary
    Kisspeptin infused for 24h induced LH surges in 75% of animals
    1 context sentence
    Summary · context
    Kisspeptin (15.2 nmol/h) was infused for 6, 12, or 24h in seasonally acyclic ewes (N = 8), and blood samples were collected hourly for 28 h (beginning 5h before the start of infusion), then every 2h for the following 22 h.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In seasonally acyclic ewes, a 12-h kisspeptin infusion induced LH surges in 50% of animals, fewer than with 24 h.

    In plain wordsIn ewes outside the breeding season, a 12-hour kisspeptin infusion caused LH surges in 50% of animals.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH surge rate with 12-h kisspeptin infusion
    Study

    sheepn = 8

    seasonally acyclic ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    15.2 nmol/h · intravenous · 12 hAs given in this study (sheep).

    Measurements

    Ewes with LH surge
    50%
    12 h infusion

    Source sentences

    Summary
    Kisspeptin infused for 24h induced LH surges in 75% of animals, and this percentage decreased with the duration of the infusion (12h = 50%; 6h = 12.5%).
    1 context sentence
    Summary · context
    Kisspeptin (15.2 nmol/h) was infused for 6, 12, or 24h in seasonally acyclic ewes (N = 8), and blood samples were collected hourly for 28 h (beginning 5h before the start of infusion), then every 2h for the following 22 h.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In seasonally acyclic ewes, a 6-h kisspeptin infusion induced LH surges in 12.5% of animals, fewer than with 24 h.

    In plain wordsIn ewes outside the breeding season, a 6-hour kisspeptin infusion caused LH surges in 12.5% of animals.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH surge rate with 6-h kisspeptin infusion
    Study

    sheepn = 8

    seasonally acyclic ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    15.2 nmol/h · intravenous · 6 hAs given in this study (sheep).

    Measurements

    Ewes with LH surge
    12.5%
    6 h infusion

    Source sentences

    Summary
    Kisspeptin infused for 24h induced LH surges in 75% of animals, and this percentage decreased with the duration of the infusion (12h = 50%; 6h = 12.5%).
    1 context sentence
    Summary · context
    Kisspeptin (15.2 nmol/h) was infused for 6, 12, or 24h in seasonally acyclic ewes (N = 8), and blood samples were collected hourly for 28 h (beginning 5h before the start of infusion), then every 2h for the following 22 h.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In kisspeptin-infused ewes, plasma estradiol was greater in ewes with an LH surge than in those without.

    In plain wordsIn ewes given kisspeptin, estradiol was higher in animals that had an LH surge than in those that did not.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma estradiol in ewes with versus without an LH surge
    Study

    sheepn = 8

    seasonally acyclic ewes
    Comparator
    Ewes without LH surge
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    15.2 nmol/h · intravenous · 6-24 hAs given in this study (sheep).

    Measurements

    Plasma estradiol
    2.23 pg/mL
    ewes with LH surge
    Plasma estradiol
    1.27 pg/mL
    ewes without LH surge

    Source sentences

    Summary
    The plasma concentration of E(2) was greater in ewes with an LH surge compared to those without LH surges; mean (+/- SEM) concentrations for the 5-h period following the Kp infusion were, respectively, 2.23 +/- 0.16 vs 1.27 +/- 0.13 pg/mL (P < 0.001).
    1 context sentence
    Summary · context
    Kisspeptin (15.2 nmol/h) was infused for 6, 12, or 24h in seasonally acyclic ewes (N = 8), and blood samples were collected hourly for 28 h (beginning 5h before the start of infusion), then every 2h for the following 22 h.
  7. 07AnimalAnimal study (in vivo)Activity measurement

    In ewes with an LH surge, plasma LH rose transiently at the start of the kisspeptin infusion.

    In plain wordsIn ewes, plasma LH rose briefly when the kisspeptin infusion started.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH at start of infusion
    Study

    sheepn: not reported in source

    seasonally acyclic ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    15.2 nmol/h · intravenous · 43 hAs given in this study (sheep).

    Measurements

    LH
    0.33 ng/mL
    5 h before infusion
    LH
    2.83 ng/mL
    5 h after infusion start

    Source sentences

    Summary
    Mean (+/- SEM) concentrations for the 5-h periods preceding and following the start of the Kp infusion were, respectively, 0.33 +/- 0.09 vs 2.83 +/- 0.49 ng/mL (P = 0.004) for LH
    2 context sentences
    Summary · context
    In all ewes with an LH surge, there was an immediate but transient increase in the plasma concentrations of LH, follicle-stimulating hormone (FSH), and growth hormone (GH) at the start of the Kp infusion.
    Summary · context
    In the first experiment, a constant iv infusion of ovine kisspeptin 10 (Kp; 15.2 nmol/h) was given to 11 seasonally acyclic ewes over 43 h.
  8. 08AnimalAnimal study (in vivo)Activity measurement

    In ewes with an LH surge, plasma FSH rose transiently at the start of the kisspeptin infusion.

    In plain wordsIn ewes, plasma FSH rose briefly when the kisspeptin infusion started.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma FSH at start of infusion
    Study

    sheepn: not reported in source

    seasonally acyclic ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    15.2 nmol/h · intravenous · 43 hAs given in this study (sheep).

    Measurements

    FSH
    0.43 ng/mL
    5 h before infusion
    FSH
    0.55 ng/mL
    5 h after infusion start

    Source sentences

    Summary
    0.43 +/- 0.05 vs 0.55 +/- 0.03 ng/mL (P = 0.015) for FSH
    2 context sentences
    Summary · context
    In all ewes with an LH surge, there was an immediate but transient increase in the plasma concentrations of LH, follicle-stimulating hormone (FSH), and growth hormone (GH) at the start of the Kp infusion.
    Summary · context
    In the first experiment, a constant iv infusion of ovine kisspeptin 10 (Kp; 15.2 nmol/h) was given to 11 seasonally acyclic ewes over 43 h.
  9. 09AnimalAnimal study (in vivo)Activity measurement

    In ewes with an LH surge, plasma growth hormone rose transiently at the start of the kisspeptin infusion.

    In plain wordsIn ewes, plasma growth hormone rose briefly when the kisspeptin infusion started.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma growth hormone at start of infusion
    Study

    sheepn: not reported in source

    seasonally acyclic ewes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    15.2 nmol/h · intravenous · 43 hAs given in this study (sheep).

    Measurements

    GH
    9.34 ng/mL
    5 h before infusion
    GH
    11.51 ng/mL
    5 h after infusion start

    Source sentences

    Summary
    9.34 +/- 1.01 vs 11.51 +/- 0.92 ng/mL (P = 0.004) for GH
    2 context sentences
    Summary · context
    In all ewes with an LH surge, there was an immediate but transient increase in the plasma concentrations of LH, follicle-stimulating hormone (FSH), and growth hormone (GH) at the start of the Kp infusion.
    Summary · context
    In the first experiment, a constant iv infusion of ovine kisspeptin 10 (Kp; 15.2 nmol/h) was given to 11 seasonally acyclic ewes over 43 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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