In mice exposed to busulfan, low-dose triptorelin pretreatment did not significantly increase primordial follicle numbers versus busulfan alone.
In plain wordsIn mice exposed to busulfan, low-dose triptorelin did not significantly increase primordial follicle numbers compared with busulfan alone.
- Outcome
- No significant changePrimordial follicles with low-dose pretreatment
- Study
mousen: not reported in source
Female FVB/NJNarl mice with busulfan-induced ovarian gonadotoxicity- Comparator
- Busulfan alone
- Outcome group
- Sex hormones and fertility · Reproductive and sexual health
- Studied dose
- 3.8 mg/kg · subcutaneousAs given in this study (mouse).
Source sentences
In the T(L)+B group, a greater number of larger primordial and primary follicles were enumerated compared with the B group; however, statistical significance was not achieved.
4 context sentences(design, population, supporting numbers)
Twenty-four sexually mature, virgin, female FVB/NJNarl mice were divided into four groups: busulfan (B); low-dose triptorelin plus busulfan (T(L)+B); high-dose triptorelin plus busulfan (T(H)+B); and control.
Mice in the T(L)+B and T(H)+B groups were injected with 3.8 and 38 mg/kg of triptorelin subcutaneously, respectively.
Four weeks later, mice in the B, T(L)+B, and T(H)+B groups were injected with busulfan intraperitoneally at a dose of 36 mg/kg.
Histologic examinations were performed 4 weeks later.