Growth hormone secretagogues reduce transient outward K+ current via phospholipase C/protein kinase C signaling pathway in rat ventricular myocytes.

Sun Q, Zang WJ, Chen C

Endocrinology7 Jan 2010Cited by 13 (Europe PMC)

PMID20056829DOI10.1210/en.2009-0877PepBankPUB-20056829

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In isolated rat ventricular myocytes, hexarelin at 10 nm significantly prolonged action potential duration.
In plain wordsIn lab tests on rat heart cells, hexarelin lengthened the electrical signal of the cell.
Peptide
Hexarelin
Outcome
IncreaseAction potential duration
Study
ratn: not reported in source
freshly isolated adult Sprague-Dawley rat ventricular myocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
10 nm · local applicationAs given in this study (rat).
Source sentences
Summary
Under current clamp, ghrelin and hexarelin (10 nm) significantly prolonged action potential duration.
1 context sentence(design, population, supporting numbers)
Summary · context
GHS and experimental agents were applied locally onto freshly isolated adult Sprague-Dawley rat ventricular myocytes and action potential morphology and I(to) was recorded using nystatin-perforated whole-cell patch-clamp recording technique.
Report a problemFND-2005682901
02LabEx vivo tissueMechanism
In isolated rat ventricular myocytes, hexarelin inhibited the transient outward potassium current in a concentration-dependent manner.
In plain wordsIn lab tests on rat heart cells, hexarelin reduced a potassium current, and a higher dose reduced it more.
Peptide
Hexarelin
Outcome
DecreaseTransient outward potassium current (I(to))
Study
ratn: not reported in source
freshly isolated adult Sprague-Dawley rat ventricular myocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated · local applicationAs given in this study (rat).
Source sentences
Summary
Under voltage clamp, hexarelin and ghrelin inhibited I(to) in a concentration-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
GHS and experimental agents were applied locally onto freshly isolated adult Sprague-Dawley rat ventricular myocytes and action potential morphology and I(to) was recorded using nystatin-perforated whole-cell patch-clamp recording technique.
Report a problemFND-2005682902

Studies that did not test the peptide alone3

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

03LabNot a test of Hexarelin aloneEx vivo tissueMechanism
In isolated rat ventricular myocytes, the GHS receptor antagonist [D-Lys(3)]GH-releasing peptide-6 and the GHS-R1a-specific antagonist BIM28163 abolished the I(to) inhibition by GHS.
In plain wordsIn lab tests on rat heart cells, two receptor blockers removed the potassium current reduction caused by the secretagogues.
Peptide
Hexarelin
Outcome
Not applicableEffect of GHS-R antagonists on I(to) inhibition
Study
ratn: not reported in source
freshly isolated adult Sprague-Dawley rat ventricular myocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
This inhibition was abolished in the presence of the GHS receptor (GHS-R) antagonist [D-Lys(3)]GH-releasing peptide-6 (10 microm) and GHS-R1a-specific antagonist BIM28163 (1 microm).
1 context sentence(design, population, supporting numbers)
Summary · context
GHS and experimental agents were applied locally onto freshly isolated adult Sprague-Dawley rat ventricular myocytes and action potential morphology and I(to) was recorded using nystatin-perforated whole-cell patch-clamp recording technique.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-2005682903
04LabNot a test of Hexarelin aloneEx vivo tissueMechanism
In isolated rat ventricular myocytes, a phospholipase C inhibitor and protein kinase C inhibitors totally reversed the GHS-induced I(to) inhibition.
In plain wordsIn lab tests on rat heart cells, blockers of two signaling enzymes fully reversed the potassium current reduction caused by the secretagogues.
Peptide
Hexarelin
Outcome
Not applicableEffect of PLC and PKC inhibitors on I(to) inhibition
Study
ratn: not reported in source
freshly isolated adult Sprague-Dawley rat ventricular myocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
GHS-induced I(to) inhibition was totally reversed by the phospholipase C inhibitor U73122 (5 microm) and protein kinase C inhibitors GO6983 (1 microm) and calphostin C (0.1 microm)
1 context sentence(design, population, supporting numbers)
Summary · context
GHS and experimental agents were applied locally onto freshly isolated adult Sprague-Dawley rat ventricular myocytes and action potential morphology and I(to) was recorded using nystatin-perforated whole-cell patch-clamp recording technique.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-2005682904
05LabNot a test of Hexarelin aloneEx vivo tissueMechanism
In isolated rat ventricular myocytes, a cAMP antagonist and a PKA inhibitor did not reverse the GHS-induced I(to) inhibition.
In plain wordsIn lab tests on rat heart cells, blockers of the cAMP and PKA pathway did not reverse the potassium current reduction.
Peptide
Hexarelin
Outcome
No significant changeEffect of cAMP and PKA inhibitors on I(to) inhibition
Study
ratn: not reported in source
freshly isolated adult Sprague-Dawley rat ventricular myocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
but not by the cAMP antagonist Rp-cAMP (100 microm) or the PKA inhibitor H89 (1 microm).
1 context sentence(design, population, supporting numbers)
Summary · context
GHS and experimental agents were applied locally onto freshly isolated adult Sprague-Dawley rat ventricular myocytes and action potential morphology and I(to) was recorded using nystatin-perforated whole-cell patch-clamp recording technique.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-2005682905

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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