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Study · In vitro (cells) · 2009

2 results

Exogenous thymosin beta4 prevents apoptosis in human intervertebral annulus cells in vitro.

Tapp H, Deepe R, Ingram JA, Yarmola EG, Bubb MR, Hanley EN Jr, Gruber HE

Biotechnic & histochemistry : official publication of the Biological Stain Commission1 Dec 2009Cited by 12 (Europe PMC)

PMID20055734 (opens in a new tab)PMCIDPMC2886502 (opens in a new tab)DOI10.3109/10520290903116884 (opens in a new tab)PepBankPUB-20055734
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human annulus cells with apoptosis induced by hydrogen peroxide or serum starvation, TB4 significantly decreased the percentage of apoptotic cells.

    In plain wordsIn disc cells in the lab, TB4 reduced the share of cells that died by programmed cell death.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseAnnulus cell apoptosis
    Study

    humann: not reported in source

    human intervertebral annulus cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The percentage of cells undergoing apoptosis decreased significantly in TB4 treated cells in both apoptosis induction designs.
    2 context sentences
    Summary · context
    Our objective here was to determine if thymosin beta(4) (TB4), a small, multifunctional 5 kDa protein with diverse activities, might block apoptosis in human annulus cells cultured in monolayer or three-dimensional (3D) culture.
    Summary · context
    Apoptosis was induced in vitro using hydrogen peroxide or serum starvation.
  2. 02LabIn vitro (cells)Efficacy outcome

    In human annulus cells, TB4 exposure did not alter proteoglycan production by DMB measurement or histological staining.

    In plain wordsIn disc cells in the lab, TB4 did not change production of proteoglycan.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeProteoglycan production
    Study

    humann: not reported in source

    human intervertebral annulus cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    TB4 exposure did not alter proteoglycan production as assessed by either DMB measurement or histological staining.
    2 context sentences
    Summary · context
    Our objective here was to determine if thymosin beta(4) (TB4), a small, multifunctional 5 kDa protein with diverse activities, might block apoptosis in human annulus cells cultured in monolayer or three-dimensional (3D) culture.
    Summary · context
    Apoptosis was induced in vitro using hydrogen peroxide or serum starvation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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