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Study · Animal study (in vivo) · 2010

9 results

Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation.

Pöll F, Lehmann D, Illing S, Ginj M, Jacobs S, Lupp A, Stumm R, Schulz S

Molecular endocrinology (Baltimore, Md.)5 Jan 2010Cited by 80 (Europe PMC)

PMID20051480 (opens in a new tab)PMCIDPMC5428126 (opens in a new tab)DOI10.1210/me.2009-0315 (opens in a new tab)PepBankPUB-20051480
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In intact animals, octreotide stimulated complete phosphorylation of four threonines in the rat sst2A receptor motif.

    In plain wordsIn animals, octreotide stimulated phosphorylation of four threonines in the rat sst2A receptor.

    Peptide
    Octreotide
    Outcome
    Increasesst2A threonine phosphorylation in vivo
    Study

    n: not reported in source

    intact animals expressing rat sst2A receptor
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We show that somatostatin and octreotide stimulate the complete phosphorylation of a cluster of four threonine residues within the cytoplasmic (353)TTETQRT(359) motif in a variety of cultured cell lines in vitro as well as in intact animals in vivo.
    1 context sentence
    Summary · context
    In the present study, we used phophosite-specific antibodies to examine agonist-induced phosphorylation of the rat sst(2A) receptor.
  2. 02LabIn vitro (cells)Mechanism

    In cells, pasireotide failed to promote substantial phosphorylation of the rat sst2A receptor.

    In plain wordsIn cells, pasireotide did not substantially stimulate phosphorylation of the rat sst2A receptor.

    Peptide
    Pasireotide
    Outcome
    No significant changesst2A phosphorylation
    Study

    n: not reported in source

    rat sst2A receptor in cultured cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, pasireotide failed to promote substantial phosphorylation and internalization of the rat sst(2A) receptor.
    1 context sentence
    Summary · context
    In the present study, we used phophosite-specific antibodies to examine agonist-induced phosphorylation of the rat sst(2A) receptor.
  3. 03LabIn vitro (cells)Mechanism

    In cells, pasireotide failed to promote substantial internalization of the rat sst2A receptor.

    In plain wordsIn cells, pasireotide did not substantially stimulate movement of the rat sst2A receptor into cells.

    Peptide
    Pasireotide
    Outcome
    No significant changesst2A internalization
    Study

    n: not reported in source

    rat sst2A receptor in cultured cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, pasireotide failed to promote substantial phosphorylation and internalization of the rat sst(2A) receptor.
    1 context sentence
    Summary · context
    In the present study, we used phophosite-specific antibodies to examine agonist-induced phosphorylation of the rat sst(2A) receptor.
  4. 04LabIn vitro (cells)Mechanism

    In cells exposed to octreotide, adding pasireotide inhibited sst2A phosphorylation and showed partial agonist behavior.

    In plain wordsIn cells exposed to octreotide, adding pasireotide inhibited receptor phosphorylation.

    Peptide
    Pasireotide
    Outcome
    Decreasesst2A phosphorylation with octreotide
    Study

    n: not reported in source

    rat sst2A receptor in cultured cells
    Comparator
    octreotide
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the presence of octreotide or SS-14, SOM230 showed partial agonist behavior, inhibiting phosphorylation, and internalization of sst(2A).
    1 context sentence
    Summary · context
    In the present study, we used phophosite-specific antibodies to examine agonist-induced phosphorylation of the rat sst(2A) receptor.
  5. 05LabIn vitro (cells)Mechanism

    In cells exposed to SS-14, adding pasireotide inhibited sst2A phosphorylation and showed partial agonist behavior.

    In plain wordsIn cells exposed to SS-14, adding pasireotide inhibited receptor phosphorylation.

    Peptide
    Pasireotide
    Outcome
    Decreasesst2A phosphorylation with SS-14
    Study

    n: not reported in source

    rat sst2A receptor in cultured cells
    Comparator
    SS-14
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the presence of octreotide or SS-14, SOM230 showed partial agonist behavior, inhibiting phosphorylation, and internalization of sst(2A).
    1 context sentence
    Summary · context
    In the present study, we used phophosite-specific antibodies to examine agonist-induced phosphorylation of the rat sst(2A) receptor.
  6. 06LabIn vitro (cells)Mechanism

    In cells exposed to octreotide, adding pasireotide inhibited sst2A internalization.

    In plain wordsIn cells exposed to octreotide, adding pasireotide inhibited receptor movement into cells.

    Peptide
    Pasireotide
    Outcome
    Decreasesst2A internalization with octreotide
    Study

    n: not reported in source

    rat sst2A receptor in cultured cells
    Comparator
    octreotide
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the presence of octreotide or SS-14, SOM230 showed partial agonist behavior, inhibiting phosphorylation, and internalization of sst(2A).
    1 context sentence
    Summary · context
    In the present study, we used phophosite-specific antibodies to examine agonist-induced phosphorylation of the rat sst(2A) receptor.
  7. 07LabIn vitro (cells)Mechanism

    In cells exposed to SS-14, adding pasireotide inhibited sst2A internalization.

    In plain wordsIn cells exposed to SS-14, adding pasireotide inhibited receptor movement into cells.

    Peptide
    Pasireotide
    Outcome
    Decreasesst2A internalization with SS-14
    Study

    n: not reported in source

    rat sst2A receptor in cultured cells
    Comparator
    SS-14
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the presence of octreotide or SS-14, SOM230 showed partial agonist behavior, inhibiting phosphorylation, and internalization of sst(2A).
    1 context sentence
    Summary · context
    In the present study, we used phophosite-specific antibodies to examine agonist-induced phosphorylation of the rat sst(2A) receptor.
  8. 08LabIn vitro (cells)Mechanism

    In cells, pasireotide-mediated phosphorylation produced relatively unstable beta-arrestin-sst2A complexes that dissociated at or near the plasma membrane.

    In plain wordsIn cells, pasireotide produced relatively unstable receptor complexes that separated at or near the cell membrane.

    Peptide
    Pasireotide
    Outcome
    Not applicableBeta-arrestin receptor complex stability
    Study

    n: not reported in source

    rat sst2A receptor in cultured cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pasireotide-mediated phosphorylation led to the formation of relatively unstable beta-arrestin-sst(2A) complexes that dissociated at or near the plasma membrane.
    1 context sentence
    Summary · context
    In the present study, we used phophosite-specific antibodies to examine agonist-induced phosphorylation of the rat sst(2A) receptor.

Studies that did not test the peptide alone1

In this study, Pasireotide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Pasireotide.

  1. 09LabNot a test of Pasireotide aloneIn vitro (cells)Mechanism

    In cells overexpressing GRK2 or GRK3, pasireotide stimulated Thr356 and Thr359 phosphorylation, but not Thr353 or Thr354.

    In plain wordsIn cells with excess receptor kinases, pasireotide stimulated phosphorylation at two receptor sites but not two others.

    Peptide
    Pasireotide
    Outcome
    MixedSelective threonine phosphorylation with GRK overexpression
    Study

    n: not reported in source

    rat sst2A receptor in cultured cells
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Upon overexpression of GRK2 or GRK3, pasireotide stimulated selective phosphorylation of Thr356 and Thr359 but not of Thr353 or Thr354 within the (353)TTETQRT(359) motif.
    1 context sentence
    Summary · context
    In the present study, we used phophosite-specific antibodies to examine agonist-induced phosphorylation of the rat sst(2A) receptor.

    In this study, Pasireotide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pasireotide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 2

    27 Oct 2026, 16:36 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    27 Oct 2026, 16:34 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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