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Study · Animal study (in vivo) · rat · 2010

8 results

Central administration of kisspeptin-10 inhibits natriuresis and diuresis induced by blood volume expansion in anesthetized male rats.

Han X, Yan M, An XF, He M, Yu JY

Acta pharmacologica Sinica21 Dec 2009Cited by 15 (Europe PMC)

PMID20023694 (opens in a new tab)PMCIDPMC4002833 (opens in a new tab)DOI10.1038/aps.2009.179 (opens in a new tab)PepBankPUB-20023694
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized male rats, intracerebroventricular kisspeptin‑10 (5 nmol) significantly inhibited the increase in urine flow induced by blood volume expansion.

    In plain wordsIn rats, kisspeptin‑10 injected into the brain reduced the extra urine flow caused by a rise in blood volume.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseVolume expansion-induced urine flow
    Study

    ratn: not reported in source

    Anesthetized male rats with blood volume expansion
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    5 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The increased urine flow and sodium excretion induced by VE were significantly inhibited by icv injection of 5 nmol kisspeptin-10 (P<0.05), which peaked 20 min after the decrease in VE.
    1 context sentence
    Summary · context
    Natriuresis and diuresis were induced by blood volume expansion (VE) in anesthetized male rats and kisspeptin-10 was intracerebroventricularly (icv) administered.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized male rats, intracerebroventricular kisspeptin‑10 (5 nmol) significantly inhibited the increase in sodium excretion induced by blood volume expansion.

    In plain wordsIn rats, kisspeptin‑10 injected into the brain reduced the extra sodium lost in urine after a rise in blood volume.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseVolume expansion-induced sodium excretion
    Study

    ratn: not reported in source

    Anesthetized male rats with blood volume expansion
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    5 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The increased urine flow and sodium excretion induced by VE were significantly inhibited by icv injection of 5 nmol kisspeptin-10 (P<0.05), which peaked 20 min after the decrease in VE.
    1 context sentence
    Summary · context
    Natriuresis and diuresis were induced by blood volume expansion (VE) in anesthetized male rats and kisspeptin-10 was intracerebroventricularly (icv) administered.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In anesthetized male rats, mean arterial blood pressure did not change during the experiment.

    In plain wordsIn rats given kisspeptin‑10 in the brain, blood pressure did not change.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeMean arterial blood pressure
    Study

    ratn: not reported in source

    Anesthetized male rats with blood volume expansion
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    5 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The mean arterial blood pressure and heart rate did not change during the experiment.
    1 context sentence
    Summary · context
    Natriuresis and diuresis were induced by blood volume expansion (VE) in anesthetized male rats and kisspeptin-10 was intracerebroventricularly (icv) administered.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In anesthetized male rats, heart rate did not change during the experiment.

    In plain wordsIn rats given kisspeptin‑10 in the brain, heart rate did not change.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeHeart rate
    Study

    ratn: not reported in source

    Anesthetized male rats with blood volume expansion
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    5 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The mean arterial blood pressure and heart rate did not change during the experiment.
    1 context sentence
    Summary · context
    Natriuresis and diuresis were induced by blood volume expansion (VE) in anesthetized male rats and kisspeptin-10 was intracerebroventricularly (icv) administered.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In anesthetized male rats during blood volume expansion, plasma AVP concentrations were significantly increased 20 min after intracerebroventricular kisspeptin‑10 (5 nmol).

    In plain wordsIn rats, kisspeptin‑10 injected into the brain raised blood levels of the hormone vasopressin.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma arginine vasopressin (AVP) during volume expansion
    Study

    ratn: not reported in source

    Anesthetized male rats with blood volume expansion
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    5 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Plasma AVP concentrations were significantly increased 20 min after icv injection of 5 nmol kisspeptin-10 during VE (P<0.05), while pretreatment with 5 nmol kisspeptin-10 did not significantly change plasma ANP concentrations.
    1 context sentence
    Summary · context
    Natriuresis and diuresis were induced by blood volume expansion (VE) in anesthetized male rats and kisspeptin-10 was intracerebroventricularly (icv) administered.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In anesthetized male rats, pretreatment with kisspeptin‑10 (5 nmol) did not significantly change plasma ANP concentrations.

    In plain wordsIn rats, kisspeptin‑10 injected into the brain did not change blood levels of the hormone ANP.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePlasma atrial natriuretic peptide (ANP) during volume expansion
    Study

    ratn: not reported in source

    Anesthetized male rats with blood volume expansion
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    5 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Plasma AVP concentrations were significantly increased 20 min after icv injection of 5 nmol kisspeptin-10 during VE (P<0.05), while pretreatment with 5 nmol kisspeptin-10 did not significantly change plasma ANP concentrations.
    1 context sentence
    Summary · context
    Natriuresis and diuresis were induced by blood volume expansion (VE) in anesthetized male rats and kisspeptin-10 was intracerebroventricularly (icv) administered.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with bilateral renal sympathetic denervation, pretreatment with kisspeptin‑10 (5 nmol) significantly inhibited volume expansion-induced natriuresis.

    In plain wordsIn rats whose kidney nerves were cut, kisspeptin‑10 in the brain still reduced the extra sodium lost in urine.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseVolume expansion-induced natriuresis in renal sympathetic denervated rats
    Study

    ratn: not reported in source

    Anesthetized male rats with blood volume expansion and bilateral renal sympathetic denervation
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    5 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, pretreatment with 5 nmol kisspeptin-10 could significantly inhibit VE-induced natriuresis and diuresis in renal sympathetic denervated rats (P<0.05).
    1 context sentence
    Summary · context
    Natriuresis and diuresis were induced by blood volume expansion (VE) in anesthetized male rats and kisspeptin-10 was intracerebroventricularly (icv) administered.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with bilateral renal sympathetic denervation, pretreatment with kisspeptin‑10 (5 nmol) significantly inhibited volume expansion-induced diuresis.

    In plain wordsIn rats whose kidney nerves were cut, kisspeptin‑10 in the brain still reduced the extra urine flow.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseVolume expansion-induced diuresis in renal sympathetic denervated rats
    Study

    ratn: not reported in source

    Anesthetized male rats with blood volume expansion and bilateral renal sympathetic denervation
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    5 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, pretreatment with 5 nmol kisspeptin-10 could significantly inhibit VE-induced natriuresis and diuresis in renal sympathetic denervated rats (P<0.05).
    1 context sentence
    Summary · context
    Natriuresis and diuresis were induced by blood volume expansion (VE) in anesthetized male rats and kisspeptin-10 was intracerebroventricularly (icv) administered.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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