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Study · Animal study (in vivo) · 2010

4 results

Reversal of second-hand cigarette smoke-induced impairment of corneal wound healing by thymosin beta4 combined with anti-inflammatory agents.

Yuan H, Ma C, Moinet L, Sato N, Martins-Green M

Investigative ophthalmology & visual science17 Dec 2009Cited by 12 (Europe PMC)

PMID20019366 (opens in a new tab)DOI10.1167/iovs.09-3692 (opens in a new tab)PepBankPUB-20019366
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In vivo, Tβ4 stimulated corneal epithelial cell migration in the presence of second-hand smoke.

    In plain wordsIn animals, Tβ4 helped eye surface cells move even when they were exposed to second-hand smoke.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCorneal epithelial cell migration in vivo with smoke
    Study

    n: not reported in source

    In vivo corneal wound with smoke exposure
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tbeta4 stimulated corneal epithelial cell migration in the presence of SSW smoke in culture and in vivo
    1 context sentence
    Summary · context
    Corneal epithelial cells in two-dimensional or organ culture were exposed to sidestream whole (SSW) smoke, a major component of second-hand CS.
  2. 02LabEx vivo tissueEfficacy outcome

    In the corneal healing model exposed to second-hand smoke, Tβ4 partially reversed the inhibition of corneal healing.

    In plain wordsIn lab and animal tests, Tβ4 partly restored eye surface healing that second-hand smoke had slowed.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCorneal healing inhibited by smoke
    Study

    n: not reported in source

    Corneal healing with smoke exposure
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    it partially reversed the inhibition of corneal healing by SSW smoke.
    1 context sentence
    Summary · context
    Corneal epithelial cells in two-dimensional or organ culture were exposed to sidestream whole (SSW) smoke, a major component of second-hand CS.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cultured corneal epithelial cells exposed to second-hand smoke, Tβ4 stimulated cell migration.

    In plain wordsIn cells, Tβ4 helped eye surface cells move even when they were exposed to second-hand smoke.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCorneal epithelial cell migration in culture with smoke
    Study

    n: not reported in source

    Corneal epithelial cells in culture exposed to sidestream whole smoke
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tbeta4 stimulated corneal epithelial cell migration in the presence of SSW smoke in culture
    1 context sentence
    Summary · context
    Corneal epithelial cells in two-dimensional or organ culture were exposed to sidestream whole (SSW) smoke, a major component of second-hand CS.

Studies that did not test the peptide alone1

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 04LabNot a test of Thymosin beta-4 (human) aloneEx vivo tissueEfficacy outcome

    Tβ4 combined with dexamethasone reversed the effects of second-hand smoke on corneal healing.

    In plain wordsIn lab and animal tests, Tβ4 together with dexamethasone, an anti-inflammatory drug, reversed the slowing of eye surface healing caused by smoke.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCorneal healing with Tβ4 plus dexamethasone
    Study

    n: not reported in source

    Corneal healing with smoke exposure
    Outcome group
    Wound healing · Eye

    Source sentences

    Summary
    However, Tbeta4 plus dexamethasone, an inhibitor of inflammation, together, reversed the effects of SSW smoke on corneal healing.
    1 context sentence
    Summary · context
    Corneal epithelial cells in two-dimensional or organ culture were exposed to sidestream whole (SSW) smoke, a major component of second-hand CS.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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