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Study · Not a test of the peptide alone · 2010

4 results

Over-expression of thymosin beta 4 promotes abnormal tooth development and stimulation of hair growth.

Cha HJ, Philp D, Lee SH, Moon HS, Kleinman HK, Nakamura T

The International journal of developmental biology1 Jan 2010Cited by 29 (Europe PMC)

PMID20013654 (opens in a new tab)DOI10.1387/ijdb.082735hc (opens in a new tab)PepBankPUB-20013654
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In transgenic mice, Tβ4 over-expression was seen especially around hair follicles and in the teeth.

    In plain wordsIn mice bred to make extra Tβ4, the extra Tβ4 was found mostly around hair follicles and in the teeth.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTβ4 over-expression site in transgenic mice
    Study

    mousen: not reported in source

    Keratin-5 promoter Tβ4 transgenic mice
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    The over-expression of thymosin beta 4 was observed especially around hair follicles and in the teeth in the transgenic mice.
    1 context sentence
    Summary · context
    Using a construct on the skin-specific keratin-5 promoter, we have developed thymosin beta 4 over-expressing transgenic mice to further study its functional roles.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In Tβ4 over-expressing transgenic mice, hair growth was accelerated.

    In plain wordsIn mice bred to make extra Tβ4, hair grew faster.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseHair growth in Tβ4 over-expressing mice
    Study

    mousen: not reported in source

    Keratin-5 promoter Tβ4 transgenic mice
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    Hair growth was accelerated.
    1 context sentence
    Summary · context
    Using a construct on the skin-specific keratin-5 promoter, we have developed thymosin beta 4 over-expressing transgenic mice to further study its functional roles.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Safety outcome

    Tβ4 over-expressing transgenic mice had abnormally-shaped white teeth and dull incisors.

    In plain wordsIn mice bred to make extra Tβ4, the teeth had an abnormal shape and the incisors were dull.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTooth development in Tβ4 over-expressing mice
    Study

    mousen: not reported in source

    Keratin-5 promoter Tβ4 transgenic mice
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    In addition, the transgenic mice had abnormally-shaped white teeth and dull incisors.
    1 context sentence
    Summary · context
    Using a construct on the skin-specific keratin-5 promoter, we have developed thymosin beta 4 over-expressing transgenic mice to further study its functional roles.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In the skin of Tβ4 over-expressing transgenic mice, laminin-5 expression was up-regulated.

    In plain wordsIn mice bred to make extra Tβ4, the skin had higher levels of laminin-5.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseLaminin-5 expression in skin
    Study

    mousen: not reported in source

    Keratin-5 promoter Tβ4 transgenic mice
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    We found that the expression of laminin-5 was up-regulated in the skin of the transgenic mice.
    1 context sentence
    Summary · context
    Using a construct on the skin-specific keratin-5 promoter, we have developed thymosin beta 4 over-expressing transgenic mice to further study its functional roles.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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