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Study · Animal study (in vivo) · rat · 2010

2 results

Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis.

Lue Y, Swerdloff R, Liu Q, Mehta H, Hikim AS, Lee KW, Jia Y, Hwang D, Cobb LJ, Cohen P, Wang C

Endocrinology1 Dec 2009Cited by 55 (Europe PMC)

PMID19952275 (opens in a new tab)DOI10.1210/en.2009-0577 (opens in a new tab)PepBankPUB-19952275
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intratesticular humanin significantly decreased GnRH antagonist-induced germ cell apoptosis at stages XIV-I of the seminiferous epithelium cycle.

    In plain wordsIn rats, humanin injected into the testis reduced sperm-cell death caused by a hormone blocker at some stages of sperm development.

    Peptide
    Humanin
    Outcome
    DecreaseGnRH-A-induced germ cell apoptosis at stages XIV-I
    Study

    ratn: not reported in source

    Rat testis with GnRH antagonist-induced germ cell apoptosis
    Comparator
    GnRH antagonist alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intratesticular injectionAs given in this study (rat).

    Source sentences

    Summary
    Intratesticular injection of HN significantly decreased GnRH-A-induced apoptosis at stages XIV-I but not stages VII-VIII.
    1 context sentence
    Summary · context
    GnRH-A treatment for 5 d increased apoptosis, mainly at stages VII-VIII.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intratesticular humanin did not significantly decrease GnRH antagonist-induced germ cell apoptosis at stages VII-VIII.

    In plain wordsIn rats, humanin injected into the testis did not reduce hormone-blocker-induced sperm-cell death at other stages of sperm development.

    Peptide
    Humanin
    Outcome
    No significant changeGnRH-A-induced germ cell apoptosis at stages VII-VIII
    Study

    ratn: not reported in source

    Rat testis with GnRH antagonist-induced germ cell apoptosis
    Comparator
    GnRH antagonist alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intratesticular injectionAs given in this study (rat).

    Source sentences

    Summary
    Intratesticular injection of HN significantly decreased GnRH-A-induced apoptosis at stages XIV-I but not stages VII-VIII.
    1 context sentence
    Summary · context
    GnRH-A treatment for 5 d increased apoptosis, mainly at stages VII-VIII.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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