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Study · Animal study (in vivo) · rat · 2010

5 results

Maturation of kisspeptinergic neurons coincides with puberty onset in male rats.

Bentsen AH, Ansel L, Simonneaux V, Tena-Sempere M, Juul A, Mikkelsen JD

Peptides26 Nov 2009Cited by 51 (Europe PMC)

PMID19944729 (opens in a new tab)DOI10.1016/j.peptides.2009.11.017 (opens in a new tab)PepBankPUB-19944729
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats at PND15, 30, 45 and 60, peripheral kisspeptin‑54 induced c-Fos in the pituitary with roughly similar effects at each age.

    In plain wordsIn male rats of different ages, kisspeptin‑54 given outside the brain switched on c-Fos in the pituitary.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    Increasec-Fos induction in the pituitary after peripheral kisspeptin-54
    Study

    ratn: not reported in source

    male rats along pubertal development
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    increasing doses · peripheralAs given in this study (rat).

    Source sentences

    Summary
    Increasing doses of kisspeptin-54 given peripherally to male rats at PND15, 30, 45, and 60 evoked roughly similar effects, as revealed by the induction of c-Fos in the pituitary and secretion of LH and testosterone.
    1 context sentence
    Summary · context
    Using immunohistochemistry and in situ hybridization, we analyzed the level of Kiss1 mRNA and kisspeptin-immunoreactivity in the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus of male rats along pubertal development.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats at PND15, 30, 45 and 60, peripheral kisspeptin‑54 evoked LH secretion with roughly similar effects at each age.

    In plain wordsIn male rats of different ages, kisspeptin‑54 given outside the brain raised LH release.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseLH secretion after peripheral kisspeptin-54
    Study

    ratn: not reported in source

    male rats along pubertal development
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    increasing doses · peripheralAs given in this study (rat).

    Source sentences

    Summary
    Increasing doses of kisspeptin-54 given peripherally to male rats at PND15, 30, 45, and 60 evoked roughly similar effects, as revealed by the induction of c-Fos in the pituitary and secretion of LH and testosterone.
    1 context sentence
    Summary · context
    Using immunohistochemistry and in situ hybridization, we analyzed the level of Kiss1 mRNA and kisspeptin-immunoreactivity in the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus of male rats along pubertal development.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rats at PND15, 30, 45 and 60, peripheral kisspeptin‑54 evoked testosterone secretion with roughly similar effects at each age.

    In plain wordsIn male rats of different ages, kisspeptin‑54 given outside the brain raised testosterone release.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseTestosterone secretion after peripheral kisspeptin-54
    Study

    ratn: not reported in source

    male rats along pubertal development
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    increasing doses · peripheralAs given in this study (rat).

    Source sentences

    Summary
    Increasing doses of kisspeptin-54 given peripherally to male rats at PND15, 30, 45, and 60 evoked roughly similar effects, as revealed by the induction of c-Fos in the pituitary and secretion of LH and testosterone.
    1 context sentence
    Summary · context
    Using immunohistochemistry and in situ hybridization, we analyzed the level of Kiss1 mRNA and kisspeptin-immunoreactivity in the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus of male rats along pubertal development.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 04AnimalEndogenous levelAnimal study (in vivo)Other

    In male rats, neurons expressing Kiss1 mRNA were first detected at PND15, increased significantly around puberty, and declined again in the adult.

    In plain wordsIn male rats, the number of cells making the body's own kisspeptin gene rose around puberty and fell again in grown rats.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    MixedKiss1 mRNA-expressing neurons across puberty
    Study

    ratn: not reported in source

    male rats along pubertal development
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Neurons expressing Kiss1 mRNA were first detected at PND15, but increased significantly around puberty, and declined again in the adult rat.
    1 context sentence
    Summary · context
    Using immunohistochemistry and in situ hybridization, we analyzed the level of Kiss1 mRNA and kisspeptin-immunoreactivity in the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus of male rats along pubertal development.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  2. 05AnimalEndogenous levelAnimal study (in vivo)Other

    In male rats, numerous kisspeptin-positive neurons were detected in the arcuate nucleus of the adult, while virtually no immunoreactive cell bodies were detectable in the AVPV at any age.

    In plain wordsIn male rats, natural kisspeptin-containing cells were found in the arcuate nucleus of grown rats but almost none in the AVPV.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseKisspeptin-immunoreactive neurons in arcuate nucleus and AVPV
    Study

    ratn: not reported in source

    male rats along pubertal development
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    While virtually no immunoreactive cell bodies were detectable in the AVPV at any age, numerous kisspeptin-positive neurons in the arcuate nucleus were detected in the adult rat.
    2 context sentences
    Summary · context
    These results show that both Kiss1 mRNA and the peptide increase in arcuate nucleus along pubertal maturation.
    Summary · context
    Using immunohistochemistry and in situ hybridization, we analyzed the level of Kiss1 mRNA and kisspeptin-immunoreactivity in the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus of male rats along pubertal development.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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