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Study · In vitro (cells) · 2010

6 results

Protective effects of [Gly14]-Humanin on beta-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction.

Jin H, Liu T, Wang WX, Xu JH, Yang PB, Lu HX, Sun QR, Hu HT

Neurochemistry international24 Nov 2009Cited by 43 (Europe PMC)

PMID19941922 (opens in a new tab)DOI10.1016/j.neuint.2009.11.015 (opens in a new tab)PepBankPUB-19941922
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In PC12 cells exposed to Abeta(25-35), pretreatment with 100 nM HNG significantly elevated cell viability.

    In plain wordsIn cells, pretreatment with a humanin derivative kept more nerve-like cells alive after amyloid beta exposure.

    Peptide
    Humanin
    Outcome
    IncreaseCell viability after Abeta(25-35)
    Study

    n: not reported in source

    PC12 cells exposed to Abeta(25-35)
    Comparator
    Abeta(25-35) alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 nM · 6 h pretreatmentAs given in this study.

    Source sentences

    Summary
    Pretreatment with 100 nM HNG 6h prior to Abeta(25-35) exposure significantly elevated cell viability, reduced Abeta(25-35)-induced cell apoptosis, stabilized mitochondrial membrane potential, and blocked cytochrome c release from mitochondria.
    1 context sentence
    Summary · context
    In the present study, we investigated the neuroprotective effects of HNG on Abeta(25-35)-induced toxicity and its potential mechanisms in PC12 cells.
  2. 02LabIn vitro (cells)Efficacy outcome

    In PC12 cells exposed to Abeta(25-35), pretreatment with 100 nM HNG reduced cell apoptosis.

    In plain wordsIn cells, pretreatment with a humanin derivative reduced cell death caused by amyloid beta.

    Peptide
    Humanin
    Outcome
    DecreaseAbeta(25-35)-induced apoptosis
    Study

    n: not reported in source

    PC12 cells exposed to Abeta(25-35)
    Comparator
    Abeta(25-35) alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 nM · 6 h pretreatmentAs given in this study.

    Source sentences

    Summary
    Pretreatment with 100 nM HNG 6h prior to Abeta(25-35) exposure significantly elevated cell viability, reduced Abeta(25-35)-induced cell apoptosis, stabilized mitochondrial membrane potential, and blocked cytochrome c release from mitochondria.
    1 context sentence
    Summary · context
    In the present study, we investigated the neuroprotective effects of HNG on Abeta(25-35)-induced toxicity and its potential mechanisms in PC12 cells.
  3. 03LabIn vitro (cells)Efficacy outcome

    In PC12 cells exposed to Abeta(25-35), pretreatment with 100 nM HNG stabilized mitochondrial membrane potential.

    In plain wordsIn cells, pretreatment with a humanin derivative kept the energy-making parts of cells steadier during amyloid beta exposure.

    Peptide
    Humanin
    Outcome
    IncreaseMitochondrial membrane potential
    Study

    n: not reported in source

    PC12 cells exposed to Abeta(25-35)
    Comparator
    Abeta(25-35) alone
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    100 nM · 6 h pretreatmentAs given in this study.

    Source sentences

    Summary
    Pretreatment with 100 nM HNG 6h prior to Abeta(25-35) exposure significantly elevated cell viability, reduced Abeta(25-35)-induced cell apoptosis, stabilized mitochondrial membrane potential, and blocked cytochrome c release from mitochondria.
    1 context sentence
    Summary · context
    In the present study, we investigated the neuroprotective effects of HNG on Abeta(25-35)-induced toxicity and its potential mechanisms in PC12 cells.
  4. 04LabIn vitro (cells)Efficacy outcome

    In PC12 cells exposed to Abeta(25-35), pretreatment with 100 nM HNG blocked cytochrome c release from mitochondria.

    In plain wordsIn cells, pretreatment with a humanin derivative stopped a cell-death signal from leaving the energy-making parts of cells.

    Peptide
    Humanin
    Outcome
    DecreaseCytochrome c release from mitochondria
    Study

    n: not reported in source

    PC12 cells exposed to Abeta(25-35)
    Comparator
    Abeta(25-35) alone
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    100 nM · 6 h pretreatmentAs given in this study.

    Source sentences

    Summary
    Pretreatment with 100 nM HNG 6h prior to Abeta(25-35) exposure significantly elevated cell viability, reduced Abeta(25-35)-induced cell apoptosis, stabilized mitochondrial membrane potential, and blocked cytochrome c release from mitochondria.
    1 context sentence
    Summary · context
    In the present study, we investigated the neuroprotective effects of HNG on Abeta(25-35)-induced toxicity and its potential mechanisms in PC12 cells.
  5. 05LabIn vitro (cells)Mechanism

    In PC12 cells, HNG ameliorated the reduction of the Bcl-2/Bax ratio induced by Abeta(25-35).

    In plain wordsIn cells, a humanin derivative eased the drop in a cell-survival balance that amyloid beta caused.

    Peptide
    Humanin
    Outcome
    IncreaseBcl-2/Bax ratio
    Study

    n: not reported in source

    PC12 cells exposed to Abeta(25-35)
    Comparator
    Abeta(25-35) alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, HNG also ameliorated the Abeta(25-35)-induced Bcl-2/Bax ratio reduction and decreased caspase-3 activity in PC12 cells.
    1 context sentence
    Summary · context
    In the present study, we investigated the neuroprotective effects of HNG on Abeta(25-35)-induced toxicity and its potential mechanisms in PC12 cells.
  6. 06LabIn vitro (cells)Mechanism

    In PC12 cells exposed to Abeta(25-35), HNG decreased caspase-3 activity.

    In plain wordsIn cells, a humanin derivative lowered the activity of an enzyme that drives cell death.

    Peptide
    Humanin
    Outcome
    DecreaseCaspase-3 activity
    Study

    n: not reported in source

    PC12 cells exposed to Abeta(25-35)
    Comparator
    Abeta(25-35) alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, HNG also ameliorated the Abeta(25-35)-induced Bcl-2/Bax ratio reduction and decreased caspase-3 activity in PC12 cells.
    1 context sentence
    Summary · context
    In the present study, we investigated the neuroprotective effects of HNG on Abeta(25-35)-induced toxicity and its potential mechanisms in PC12 cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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