Hexarelin suppresses high lipid diet and vitamin D3-induced atherosclerosis in the rat.

Pang J, Xu Q, Xu X, Yin H, Xu R, Guo S, Hao W, Wang L, Chen C, Cao JM

Peptides30 Nov 2009Cited by 41 (Europe PMC)

PMID19931584DOI10.1016/j.peptides.2009.11.007PepBankPUB-19931584

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with diet- and vitamin D3-induced atherosclerosis, hexarelin suppressed the formation of atherosclerotic plaques.
In plain wordsIn rats with induced artery disease, hexarelin reduced the formation of artery plaques.
Peptide
Hexarelin
Outcome
DecreaseAtherosclerotic plaque formation
Study
ratn: not reported in source
vitamin D3 and high-fat emulsion induced atherosclerosis in SD rats
Outcome group
Cardiovascular events · Cardiovascular
Studied dose
Dose not stated · subcutaneous · 30 daysAs given in this study (rat).
Source sentences
Summary
Hexarelin suppressed the formation of atherosclerotic plaques and neointima, partially reversed serum HDL-c/LDL-c ratio and increased the levels of serum NO and aortic mRNAs of eNOS, GHSR and CD36 in As rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Atherosclearosis was induced by a short period (4 days) of vitamin D(3) and chronic (three months) intragastric feeding of high fat emulsion (containing 0.5% propylthiouracil) in adult SD rats.
Summary · context
Some As rats received chronic hexarelin (a variant of GHRP) injection (SC BID, 30 days) and normal rats received placebo as control.
Report a problemFND-1993158401
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with diet- and vitamin D3-induced atherosclerosis, hexarelin suppressed neointima formation.
In plain wordsIn rats with induced artery disease, hexarelin reduced the formation of new inner artery wall tissue.
Peptide
Hexarelin
Outcome
DecreaseNeointima formation
Study
ratn: not reported in source
vitamin D3 and high-fat emulsion induced atherosclerosis in SD rats
Outcome group
Cardiovascular events · Cardiovascular
Studied dose
Dose not stated · subcutaneous · 30 daysAs given in this study (rat).
Source sentences
Summary
Hexarelin suppressed the formation of atherosclerotic plaques and neointima, partially reversed serum HDL-c/LDL-c ratio and increased the levels of serum NO and aortic mRNAs of eNOS, GHSR and CD36 in As rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Atherosclearosis was induced by a short period (4 days) of vitamin D(3) and chronic (three months) intragastric feeding of high fat emulsion (containing 0.5% propylthiouracil) in adult SD rats.
Summary · context
Some As rats received chronic hexarelin (a variant of GHRP) injection (SC BID, 30 days) and normal rats received placebo as control.
Report a problemFND-1993158402
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with diet- and vitamin D3-induced atherosclerosis, hexarelin partially reversed the fall in the serum HDL-c/LDL-c ratio.
In plain wordsIn rats with induced artery disease, hexarelin partly restored the ratio of good to bad cholesterol.
Peptide
Hexarelin
Outcome
IncreaseSerum HDL-c/LDL-c ratio
Study
ratn: not reported in source
vitamin D3 and high-fat emulsion induced atherosclerosis in SD rats
Outcome group
Lipids · Cardiovascular
Studied dose
Dose not stated · subcutaneous · 30 daysAs given in this study (rat).
Source sentences
Summary
Hexarelin suppressed the formation of atherosclerotic plaques and neointima, partially reversed serum HDL-c/LDL-c ratio and increased the levels of serum NO and aortic mRNAs of eNOS, GHSR and CD36 in As rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Atherosclearosis was induced by a short period (4 days) of vitamin D(3) and chronic (three months) intragastric feeding of high fat emulsion (containing 0.5% propylthiouracil) in adult SD rats.
Summary · context
Some As rats received chronic hexarelin (a variant of GHRP) injection (SC BID, 30 days) and normal rats received placebo as control.
Report a problemFND-1993158403
04AnimalAnimal study (in vivo)Mechanism
In rats with diet- and vitamin D3-induced atherosclerosis, hexarelin increased serum nitric oxide levels.
In plain wordsIn rats with induced artery disease, hexarelin raised blood levels of nitric oxide.
Peptide
Hexarelin
Outcome
IncreaseSerum nitric oxide
Study
ratn: not reported in source
vitamin D3 and high-fat emulsion induced atherosclerosis in SD rats
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated · subcutaneous · 30 daysAs given in this study (rat).
Source sentences
Summary
Hexarelin suppressed the formation of atherosclerotic plaques and neointima, partially reversed serum HDL-c/LDL-c ratio and increased the levels of serum NO and aortic mRNAs of eNOS, GHSR and CD36 in As rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Atherosclearosis was induced by a short period (4 days) of vitamin D(3) and chronic (three months) intragastric feeding of high fat emulsion (containing 0.5% propylthiouracil) in adult SD rats.
Summary · context
Some As rats received chronic hexarelin (a variant of GHRP) injection (SC BID, 30 days) and normal rats received placebo as control.
Report a problemFND-1993158404
05AnimalAnimal study (in vivo)Mechanism
In rats with diet- and vitamin D3-induced atherosclerosis, hexarelin increased aortic eNOS mRNA.
In plain wordsIn rats with induced artery disease, hexarelin raised aortic expression of the nitric oxide enzyme eNOS.
Peptide
Hexarelin
Outcome
IncreaseAortic eNOS mRNA
Study
ratn: not reported in source
vitamin D3 and high-fat emulsion induced atherosclerosis in SD rats
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated · subcutaneous · 30 daysAs given in this study (rat).
Source sentences
Summary
Hexarelin suppressed the formation of atherosclerotic plaques and neointima, partially reversed serum HDL-c/LDL-c ratio and increased the levels of serum NO and aortic mRNAs of eNOS, GHSR and CD36 in As rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Atherosclearosis was induced by a short period (4 days) of vitamin D(3) and chronic (three months) intragastric feeding of high fat emulsion (containing 0.5% propylthiouracil) in adult SD rats.
Summary · context
Some As rats received chronic hexarelin (a variant of GHRP) injection (SC BID, 30 days) and normal rats received placebo as control.
Report a problemFND-1993158405
06AnimalAnimal study (in vivo)Mechanism
In rats with diet- and vitamin D3-induced atherosclerosis, hexarelin increased aortic GHSR mRNA.
In plain wordsIn rats with induced artery disease, hexarelin raised aortic expression of its own receptor.
Peptide
Hexarelin
Outcome
IncreaseAortic GHSR mRNA
Study
ratn: not reported in source
vitamin D3 and high-fat emulsion induced atherosclerosis in SD rats
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated · subcutaneous · 30 daysAs given in this study (rat).
Source sentences
Summary
Hexarelin suppressed the formation of atherosclerotic plaques and neointima, partially reversed serum HDL-c/LDL-c ratio and increased the levels of serum NO and aortic mRNAs of eNOS, GHSR and CD36 in As rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Atherosclearosis was induced by a short period (4 days) of vitamin D(3) and chronic (three months) intragastric feeding of high fat emulsion (containing 0.5% propylthiouracil) in adult SD rats.
Summary · context
Some As rats received chronic hexarelin (a variant of GHRP) injection (SC BID, 30 days) and normal rats received placebo as control.
Report a problemFND-1993158406
07AnimalAnimal study (in vivo)Mechanism
In rats with diet- and vitamin D3-induced atherosclerosis, hexarelin increased aortic CD36 mRNA.
In plain wordsIn rats with induced artery disease, hexarelin raised aortic expression of CD36.
Peptide
Hexarelin
Outcome
IncreaseAortic CD36 mRNA
Study
ratn: not reported in source
vitamin D3 and high-fat emulsion induced atherosclerosis in SD rats
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated · subcutaneous · 30 daysAs given in this study (rat).
Source sentences
Summary
Hexarelin suppressed the formation of atherosclerotic plaques and neointima, partially reversed serum HDL-c/LDL-c ratio and increased the levels of serum NO and aortic mRNAs of eNOS, GHSR and CD36 in As rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Atherosclearosis was induced by a short period (4 days) of vitamin D(3) and chronic (three months) intragastric feeding of high fat emulsion (containing 0.5% propylthiouracil) in adult SD rats.
Summary · context
Some As rats received chronic hexarelin (a variant of GHRP) injection (SC BID, 30 days) and normal rats received placebo as control.
Report a problemFND-1993158407
08AnimalAnimal study (in vivo)Mechanism
In rats with diet- and vitamin D3-induced atherosclerosis, hexarelin decreased calcium sedimentation in the aortic wall.
In plain wordsIn rats with induced artery disease, hexarelin reduced calcium deposits in the aortic wall.
Peptide
Hexarelin
Outcome
DecreaseAortic wall calcium sedimentation
Study
ratn: not reported in source
vitamin D3 and high-fat emulsion induced atherosclerosis in SD rats
Outcome group
Cardiovascular events · Cardiovascular
Studied dose
Dose not stated · subcutaneous · 30 daysAs given in this study (rat).
Source sentences
Summary
Hexarelin also decreased [(3)H]-TdR incorporation in cultured vascular smooth muscle cell (VSMC) and calcium sedimentation in aortic wall.
2 context sentences(design, population, supporting numbers)
Summary · context
Atherosclearosis was induced by a short period (4 days) of vitamin D(3) and chronic (three months) intragastric feeding of high fat emulsion (containing 0.5% propylthiouracil) in adult SD rats.
Summary · context
Some As rats received chronic hexarelin (a variant of GHRP) injection (SC BID, 30 days) and normal rats received placebo as control.
Report a problemFND-1993158408
09LabIn vitro (cells)Mechanism
In cultured vascular smooth muscle cells, hexarelin decreased tritiated thymidine incorporation.
In plain wordsIn lab-grown artery muscle cells, hexarelin reduced DNA building, a sign of cell multiplication.
Peptide
Hexarelin
Outcome
DecreaseVascular smooth muscle cell proliferation (thymidine incorporation)
Study
n: not reported in source
cultured vascular smooth muscle cells
Outcome group
Cardiovascular events · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Hexarelin also decreased [(3)H]-TdR incorporation in cultured vascular smooth muscle cell (VSMC) and calcium sedimentation in aortic wall.
Report a problemFND-1993158409
10LabIn vitro (cells)Mechanism
In cells exposed to ox-LDL, hexarelin decreased foam cell formation.
In plain wordsIn lab tests on cells exposed to oxidized cholesterol, hexarelin reduced the formation of fat-filled foam cells.
Peptide
Hexarelin
Outcome
DecreaseFoam cell formation induced by ox-LDL
Study
n: not reported in source
ox-LDL-induced foam cell formation
Outcome group
Cardiovascular events · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, foam cell formation induced by ox-LDL was decreased by hexarelin.
Report a problemFND-1993158410

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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