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Study · Animal study (in vivo) · mouse · 2010

10 results

Traumatic brain injury in mice and pentadecapeptide BPC 157 effect.

Tudor M, Jandric I, Marovic A, Gjurasin M, Perovic D, Radic B, Blagaic AB, Kolenc D, Brcic L, Zarkovic K, Seiwerth S, Sikiric P

Regulatory peptides18 Nov 2009Cited by 32 (Europe PMC)

PMID19931318 (opens in a new tab)DOI10.1016/j.regpep.2009.11.012 (opens in a new tab)PepBankPUB-19931318
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury, BPC‑157 markedly attenuated damage and improved early outcome over 24 hours.

    In plain wordsIn mice with a brain injury, BPC‑157 clearly reduced damage and improved early outcome over 24 hours.

    Peptide
    BPC-157
    Outcome
    DecreaseBrain damage and early outcome after traumatic brain injury
    Study

    mousen: not reported in source

    Traumatic brain injury by falling weight
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10.0 µg/kg, 10.0 ng/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    After an induced traumatic brain injury (TBI) in mice by a falling weight, BPC 157 regimens (10.0microg, 10.0ng/kgi.p.) demonstrated a marked attenuation of damage with an improved early outcome
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury, BPC‑157 gave minimal postponed mortality throughout the 24 hour post-injury period.

    In plain wordsIn mice with a brain injury, BPC‑157 led to very few later deaths in the first 24 hours.

    Peptide
    BPC-157
    Outcome
    DecreasePostponed mortality over 24 hours
    Study

    mousen: not reported in source

    Traumatic brain injury by falling weight
    Outcome group
    Mortality · Nervous system and cognition
    Studied dose
    10.0 µg/kg, 10.0 ng/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    and a minimal postponed mortality throughout a 24h post-injury period.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury, BPC‑157 gave less intense traumatic lesions, including subarachnoidal and intraventricular haemorrhage and brain laceration.

    In plain wordsIn mice with a brain injury, BPC‑157 led to less severe bleeding and tearing in the brain.

    Peptide
    BPC-157
    Outcome
    DecreaseTraumatic lesion intensity (haemorrhage, laceration)
    Study

    mousen: not reported in source

    Traumatic brain injury by falling weight
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10.0 µg/kg, 10.0 ng/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Ultimately, the traumatic lesions (subarachnoidal and intraventricular haemorrhage, brain laceration, haemorrhagic laceration) were less intense and consecutive brain edema had considerably improved.
    1 context sentence
    Summary · context
    After an induced traumatic brain injury (TBI) in mice by a falling weight, BPC 157 regimens (10.0microg, 10.0ng/kgi.p.) demonstrated a marked attenuation of damage with an improved early outcome and a minimal postponed mortality throughout a 24h post-injury period.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury, BPC‑157 considerably improved consecutive brain edema.

    In plain wordsIn mice with a brain injury, BPC‑157 clearly reduced brain swelling.

    Peptide
    BPC-157
    Outcome
    DecreaseBrain edema
    Study

    mousen: not reported in source

    Traumatic brain injury by falling weight
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10.0 µg/kg, 10.0 ng/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    consecutive brain edema had considerably improved.
    1 context sentence
    Summary · context
    After an induced traumatic brain injury (TBI) in mice by a falling weight, BPC 157 regimens (10.0microg, 10.0ng/kgi.p.) demonstrated a marked attenuation of damage with an improved early outcome and a minimal postponed mortality throughout a 24h post-injury period.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury, BPC‑157 given 30 minutes before injury improved the conscious/unconscious/death ratio across a range of force impulses.

    In plain wordsIn mice with a brain injury, BPC‑157 given before the injury improved the share of mice that stayed conscious.

    Peptide
    BPC-157
    Outcome
    IncreaseConscious/unconscious/death ratio (prophylactic, 30 min before injury)
    Study

    mousen: not reported in source

    Traumatic brain injury by falling weight
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10.0 µg/kg, 10.0 ng/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Given prophylactically (30 min before TBI) the improved conscious/unconscious/death ratio in TBI-mice was after force impulses of 0.068 Ns, 0.093 Ns, 0.113 Ns, 0.130 Ns, 0.145 Ns, and 0.159 Ns.
    1 context sentence
    Summary · context
    After an induced traumatic brain injury (TBI) in mice by a falling weight, BPC 157 regimens (10.0microg, 10.0ng/kgi.p.) demonstrated a marked attenuation of damage with an improved early outcome and a minimal postponed mortality throughout a 24h post-injury period.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury, both the microgram and nanogram regimens of BPC‑157 reduced unconsciousness at force impulses of 0.068-0.145 Ns.

    In plain wordsIn mice with a brain injury, both BPC‑157 doses reduced unconsciousness after mild to strong impacts.

    Peptide
    BPC-157
    Outcome
    DecreaseUnconsciousness at force impulses 0.068-0.145 Ns
    Study

    mousen: not reported in source

    Traumatic brain injury by falling weight
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10.0 µg/kg, 10.0 ng/kg · intraperitonealAs given in this study (mouse).

    Measurements

    Force impulse
    0.068 to 0.145 Ns
    TBI mice, both regimens

    Source sentences

    Summary
    Counteraction (with a reduction of unconsciousness, lower mortality) with both microg- and ng-regimens included the force impulses of 0.068-0.145 Ns.
    1 context sentence
    Summary · context
    After an induced traumatic brain injury (TBI) in mice by a falling weight, BPC 157 regimens (10.0microg, 10.0ng/kgi.p.) demonstrated a marked attenuation of damage with an improved early outcome and a minimal postponed mortality throughout a 24h post-injury period.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury, both the microgram and nanogram regimens of BPC‑157 gave lower mortality at force impulses of 0.068-0.145 Ns.

    In plain wordsIn mice with a brain injury, both BPC‑157 doses lowered deaths after mild to strong impacts.

    Peptide
    BPC-157
    Outcome
    DecreaseMortality at force impulses 0.068-0.145 Ns
    Study

    mousen: not reported in source

    Traumatic brain injury by falling weight
    Outcome group
    Mortality · Nervous system and cognition
    Studied dose
    10.0 µg/kg, 10.0 ng/kg · intraperitonealAs given in this study (mouse).

    Measurements

    Force impulse
    0.068 to 0.145 Ns
    TBI mice, both regimens

    Source sentences

    Summary
    Counteraction (with a reduction of unconsciousness, lower mortality) with both microg- and ng-regimens included the force impulses of 0.068-0.145 Ns.
    1 context sentence
    Summary · context
    After an induced traumatic brain injury (TBI) in mice by a falling weight, BPC 157 regimens (10.0microg, 10.0ng/kgi.p.) demonstrated a marked attenuation of damage with an improved early outcome and a minimal postponed mortality throughout a 24h post-injury period.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury, a higher regimen of BPC‑157 was also effective against the maximal force impulse of 0.159 Ns.

    In plain wordsIn mice with a brain injury, a higher dose of BPC‑157 also worked after the strongest impact tested.

    Peptide
    BPC-157
    Outcome
    IncreaseOutcome at maximal force impulse 0.159 Ns
    Study

    mousen: not reported in source

    Traumatic brain injury by falling weight
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Higher regimen · intraperitonealAs given in this study (mouse).

    Measurements

    Force impulse
    0.159 Ns
    maximal impulse, higher regimen

    Source sentences

    Summary
    A higher regimen presented effectiveness also against the maximal force impulse (0.159 Ns).
    1 context sentence
    Summary · context
    After an induced traumatic brain injury (TBI) in mice by a falling weight, BPC 157 regimens (10.0microg, 10.0ng/kgi.p.) demonstrated a marked attenuation of damage with an improved early outcome and a minimal postponed mortality throughout a 24h post-injury period.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury at a force impulse of 0.093 Ns, BPC‑157 given immediately before injury was beneficial.

    In plain wordsIn mice with a brain injury, BPC‑157 given right before the injury helped.

    Peptide
    BPC-157
    Outcome
    IncreaseOutcome with BPC 157 immediately before injury (0.093 Ns)
    Study

    mousen: not reported in source

    Traumatic brain injury by falling weight
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10.0 µg/kg, 10.0 ng/kg · intraperitonealAs given in this study (mouse).

    Measurements

    Force impulse
    0.093 Ns
    BPC 157 immediately before injury

    Source sentences

    Summary
    Furthermore, BPC 157 application immediately prior to injury was beneficial in mice subjected to force impulses of 0.093 Ns-TBI.
    1 context sentence
    Summary · context
    After an induced traumatic brain injury (TBI) in mice by a falling weight, BPC 157 regimens (10.0microg, 10.0ng/kgi.p.) demonstrated a marked attenuation of damage with an improved early outcome and a minimal postponed mortality throughout a 24h post-injury period.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In mice with more severe traumatic brain injury, the time relation for improving the conscious/unconscious/death ratio with BPC‑157 was 5 min (0.130 Ns), 20 min (0.145 Ns) and 30 min (0.159 Ns); the abstract does not say whether this was before or after injury.

    In plain wordsIn mice with severe brain injury, BPC‑157 improved outcome at 5, 20 or 30 minutes, by impact. Timing versus injury is not stated.

    Peptide
    BPC-157
    Outcome
    IncreaseTime relation for improved conscious/unconscious/death ratio by force impulse
    Study

    mousen: not reported in source

    Traumatic brain injury by falling weight
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10.0 µg/kg, 10.0 ng/kg · intraperitonealAs given in this study (mouse).

    Measurements

    Time relation
    5 min
    0.130 Ns TBI
    Time relation
    20 min
    0.145 Ns TBI
    Time relation
    30 min
    0.159 Ns TBI

    Source sentences

    Summary
    For a more severe force impulse (0.130 Ns, 0.145 Ns, or 0159 Ns), the time-relation to improve the conscious/unconscious/death ratio was: 5 min (0.130 Ns-TBI), 20 min (0.145 Ns-TBI) or 30 min (0.159 Ns-TBI).
    1 context sentence
    Summary · context
    After an induced traumatic brain injury (TBI) in mice by a falling weight, BPC 157 regimens (10.0microg, 10.0ng/kgi.p.) demonstrated a marked attenuation of damage with an improved early outcome and a minimal postponed mortality throughout a 24h post-injury period.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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