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Study · Measured the body's own peptide · 2009

1 result

Peptidomics of prolyl endopeptidase in the central nervous system.

Nolte WM, Tagore DM, Lane WS, Saghatelian A

Biochemistry1 Dec 2009Cited by 38 (Europe PMC)

PMID19911840 (opens in a new tab)PMCIDPMC2813186 (opens in a new tab)DOI10.1021/bi901637c (opens in a new tab)PepBankPUB-19911840
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In mouse central nervous system peptidomics, thymosin-beta4 was identified as a known substrate regulated by Prep activity.

    In plain wordsIn mice, a study of a brain enzyme listed the body's own thymosin-beta4 among peptides already known to be cut by that enzyme.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableThymosin-beta4 as a Prep-regulated peptide in the CNS
    Study

    mousen: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    This approach was validated by the identification of known Prep substrates, such as the neuropeptide substance P and thymosin-beta4
    1 context sentence
    Summary · context
    Using an unbiased mass spectrometry (MS)-based peptidomics platform, we identified Prep-regulated peptides in the central nervous system (CNS) of mice by measuring changes in the peptidome as a function of Prep activity.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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