GnRH agonist versus recombinant HCG in an oocyte donation programme: a randomized, prospective, controlled, assessor-blind study.

Melo M, Busso CE, Bellver J, Alama P, Garrido N, Meseguer M, Pellicer A, Remohí J

Reproductive biomedicine online1 Oct 2009Cited by 86 (Europe PMC)

PMID19909588DOI10.1016/j.rbmo.2009.06.001PepBankPUB-19909588

Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanRandomized controlled trialSafety outcome
In oocyte donors, OHSS was less frequent with triptorelin than recombinant HCG.
In plain wordsIn oocyte donors, ovarian hyperstimulation syndrome was less frequent with triptorelin than recombinant HCG.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseOvarian hyperstimulation syndrome
Study
n = 100
Comparator
Recombinant HCG
Analysis
Primary
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
0.2 mg single bolusAs given in this study (human).
Measurements
P value
0.003 none
OHSS rate, triptorelin vs recombinant HCG
Source sentences
Summary
The OHSS rate was higher in donors that received recombinant HCG ( P = 0.003).
2 context sentences(design, population, supporting numbers)
Summary · context
The cycle characteristics of 100 oocyte donors undergoing ovarian stimulation and IVF outcomes of their 100 oocyte recipients were analysed.
Summary · context
Donors were prospectively randomized into two groups on the last day of ovarian stimulation: Group I received a single bolus of 0.2 mg of triptorelin and Group II received 250 microg of recombinant HCG.
Report a problemFND-1990958803
02HumanRandomized controlled trialEfficacy outcome
In oocyte donors, triptorelin and recombinant HCG did not differ in the number of oocytes retrieved.
In plain wordsIn oocyte donors, triptorelin and recombinant HCG produced similar numbers of retrieved oocytes.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeOocytes retrieved
Study
n = 100
Comparator
Recombinant HCG
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mg single bolusAs given in this study (human).
Source sentences
Summary
No differences were observed in the number of oocytes retrieved or in the proportion of metaphase II oocytes between the groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The cycle characteristics of 100 oocyte donors undergoing ovarian stimulation and IVF outcomes of their 100 oocyte recipients were analysed.
Summary · context
Donors were prospectively randomized into two groups on the last day of ovarian stimulation: Group I received a single bolus of 0.2 mg of triptorelin and Group II received 250 microg of recombinant HCG.
Report a problemFND-1990958801
03HumanRandomized controlled trialEfficacy outcome
In oocyte donors, triptorelin and recombinant HCG did not differ in the proportion of metaphase II oocytes.
In plain wordsIn oocyte donors, triptorelin and recombinant HCG produced similar proportions of mature oocytes.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeMetaphase II oocyte proportion
Study
n = 100
Comparator
Recombinant HCG
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mg single bolusAs given in this study (human).
Source sentences
Summary
No differences were observed in the number of oocytes retrieved or in the proportion of metaphase II oocytes between the groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The cycle characteristics of 100 oocyte donors undergoing ovarian stimulation and IVF outcomes of their 100 oocyte recipients were analysed.
Summary · context
Donors were prospectively randomized into two groups on the last day of ovarian stimulation: Group I received a single bolus of 0.2 mg of triptorelin and Group II received 250 microg of recombinant HCG.
Report a problemFND-1990958802
04HumanRandomized controlled trialEfficacy outcome
In the oocyte donation programme, IVF parameters and outcome did not differ significantly between triptorelin and recombinant HCG groups.
In plain wordsIn the donation programme, IVF results did not differ significantly between triptorelin and recombinant HCG groups.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeIVF parameters and outcome
Study
n = 100
Comparator
Recombinant HCG
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mg single bolusAs given in this study (human).
Source sentences
Summary
Moreover, there was no significant difference between IVF parameters and outcome in the two groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The cycle characteristics of 100 oocyte donors undergoing ovarian stimulation and IVF outcomes of their 100 oocyte recipients were analysed.
Summary · context
Donors were prospectively randomized into two groups on the last day of ovarian stimulation: Group I received a single bolus of 0.2 mg of triptorelin and Group II received 250 microg of recombinant HCG.
Report a problemFND-1990958804